scispace - formally typeset
Search or ask a question
Institution

University of Kentucky

EducationLexington, Kentucky, United States
About: University of Kentucky is a education organization based out in Lexington, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 43933 authors who have published 92195 publications receiving 3256087 citations. The organization is also known as: UK.


Papers
More filters
Journal ArticleDOI
25 Apr 2013-Cell
TL;DR: It is shown that an epigenetic histone mark, H3K36me3, is required in vivo to recruit the mismatch recognition protein hMutSα onto chromatin through direct interactions with the hMSH6 PWWP domain.

504 citations

Journal ArticleDOI
TL;DR: The NSSG convened a conference of health care providers, all involved in various aspects of NS, to develop guidelines for use by pediatricians in the diagnosis and management of individuals with NS and to provide updated genetic findings.
Abstract: Noonan syndrome (NS) is a common, clinically and genetically heterogeneous condition characterized by distinctive facial features, short stature, chest deformity, congenital heart disease, and other comorbidities. Gene mutations identified in individuals with the NS phenotype are involved in the Ras/MAPK (mitogen-activated protein kinase) signal transduction pathway and currently explain ∼61% of NS cases. Thus, NS frequently remains a clinical diagnosis. Because of the variability in presentation and the need for multidisciplinary care, it is essential that the condition be identified and managed comprehensively. The Noonan Syndrome Support Group (NSSG) is a nonprofit organization committed to providing support, current information, and understanding to those affected by NS. The NSSG convened a conference of health care providers, all involved in various aspects of NS, to develop these guidelines for use by pediatricians in the diagnosis and management of individuals with NS and to provide updated genetic findings.

504 citations

Journal ArticleDOI
TL;DR: Two brief indices of sensation seeking are developed, a four-item measure that retains the framework of the Sensation Seeking Scale-Form V (SSS-V) and a shorter two- item measure focusing on the risk-taking elements of sensation seek.

503 citations

Journal ArticleDOI
TL;DR: Well-studied examples that show how a disturbance of a fine-tuned balance of factors regulates splice site selection can cause human disease are discussed.

503 citations

Journal ArticleDOI
TL;DR: This paper introduced the risk perception attitude (RPA) framework that categorizes individuals into one of four attitudinal groups: responsive (high risk, high efficacy), avoidance, proactive, and indifference.
Abstract: Evidence of a direct correlation between risk perception and self-protective behavior is ambiguous at best. Witte's (1992, 1994) extended parallel process model (EPPM) explains many contradictory findings by pointing out the moderating role played by efficacy beliefs. Working from the EPPM, this article introduces the risk perception attitude (RPA) framework that categorizes individuals into one of four attitudinal groups: responsive (high risk, high efficacy), avoidance (high risk, low efficacy), proactive (low risk, high efficacy), and indifference (low risk, low efficacy). We conducted two studies to test our hypotheses that these groups differ in their self-protective motivation, intention to seek information, behavioral intention, knowledge acquisition, and time spent seeking information. Results, though not entirely consistent, suggest that, when risk and efficacy are made salient (Study 1), people's risk perception guides most of their subsequent actions, but in a natural context (Study 2), risk and efficacy jointly affect subsequent action.

502 citations


Authors

Showing all 44305 results

NameH-indexPapersCitations
Mark P. Mattson200980138033
Carlo M. Croce1981135189007
Charles A. Dinarello1901058139668
Richard A. Gibbs172889249708
Gang Chen1673372149819
David A. Bennett1671142109844
Carl W. Cotman165809105323
Rodney S. Ruoff164666194902
David Tilman158340149473
David Cella1561258106402
Richard E. Smalley153494111117
Deepak L. Bhatt1491973114652
Kevin Murphy146728120475
Jian Yang1421818111166
Thomas J. Smith1401775113919
Network Information
Related Institutions (5)
University of Minnesota
257.9K papers, 11.9M citations

98% related

University of Wisconsin-Madison
237.5K papers, 11.8M citations

97% related

University of Pittsburgh
201K papers, 9.6M citations

96% related

Cornell University
235.5K papers, 12.2M citations

96% related

University of Pennsylvania
257.6K papers, 14.1M citations

96% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023108
2022532
20214,329
20204,216
20193,965
20183,605