Institution
University of Kentucky
Education•Lexington, Kentucky, United States•
About: University of Kentucky is a education organization based out in Lexington, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 43933 authors who have published 92195 publications receiving 3256087 citations. The organization is also known as: UK.
Topics: Population, Poison control, Health care, Oxidative stress, Cancer
Papers published on a yearly basis
Papers
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TL;DR: In this article, a review deals with abiotic/biotic modes of pyrite oxidation and the mechanistic involvement of OH, O2, and Fe3+ in the process in low/high pH environments.
Abstract: Sulfide oxidation, part of sulfur's biotic/abiotic cycle, is an important natural phenomenon. However, because of the sulfide's association with metallic ores and fossil fuels in the form of pyrite (FeS2) and the world's increasing demand for metals and fossil fuels, sulfide oxidation in nature is in some state of perturbation. This perturbation, which results from land disturbances (e.g., mining, and/or ore processing), produces acid drainage often enriched with heavy metals. This acid drainage, commonly referred to as acid mine drainage (AMD), has become an economic and environmental burden. This review deals with abiotic/biotic modes of pyrite oxidation and the mechanistic involvement of OH‐, O2, and Fe3+ in the pyrite oxidation process in low/high pH environments. Also included is recent evidence on the potential involvement of CO2 in catalyzing pyrite oxidation in near‐neutral and alkaline environments. Finally, the review deals with various pyrite‐oxidation control approaches, the merits of...
559 citations
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TL;DR: In this paper, the authors provide an updated and in-depth review of some of the most exciting and important developments in the processing and properties of carbon nanotubes, including their mechanical, chemical, electrical, thermal, and optical properties.
Abstract: The goal of this article is to provide an updated and in-depth review of some of the most exciting and important developments in the processing and properties of carbon nanotubes. Nanotubes can be formed in various structures using several different processing methods. The synthesis methods used to produce specific kinds of nanotubes are discussed and a comparison is made between the methods used by researchers and industrial producers. This is followed by an overview and discussion of what makes carbon nanotubes interesting to so many: their mechanical, chemical, electrical, thermal, and optical properties. The article ends with a discussion of the future outlook for the study of carbon nanotubes.
559 citations
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TL;DR: A new integrative model of brain aging is suggested in which genomic alterations in early adulthood initiate interacting cascades of decreased signaling and synaptic plasticity in neurons, extracellular changes, and increased myelin turnover-fueled inflammation in glia that cumulatively induce aging-related cognitive impairment.
Abstract: Gene expression microarrays provide a powerful new tool for studying complex processes such as brain aging. However, inferences from microarray data are often hindered by multiple comparisons, small sample sizes, and uncertain relationships to functional endpoints. Here we sought gene expression correlates of aging-dependent cognitive decline, using statistical profiling of gene microarrays in well powered groups of young, mid-aged, and aged rats (n = 10 per group). Animals were trained on two memory tasks, and the hippocampal CA1 region of each was analyzed on an individual microarray (one chip per animal). Aging- and cognition-related genes were identified by testing each gene by ANOVA (for aging effects) and then by Pearson's test (correlating expression with memory). Genes identified by this algorithm were associated with several phenomena known to be aging-dependent, including inflammation, oxidative stress, altered protein processing, and decreased mitochondrial function, but also with multiple processes not previously linked to functional brain aging. These novel processes included downregulated early response signaling, biosynthesis and activity-regulated synaptogenesis, and upregulated myelin turnover, cholesterol synthesis, lipid and monoamine metabolism, iron utilization, structural reorganization, and intracellular Ca2+ release pathways. Multiple transcriptional regulators and cytokines also were identified. Although most gene expression changes began by mid-life, cognition was not clearly impaired until late life. Collectively, these results suggest a new integrative model of brain aging in which genomic alterations in early adulthood initiate interacting cascades of decreased signaling and synaptic plasticity in neurons, extracellular changes, and increased myelin turnover-fueled inflammation in glia that cumulatively induce aging-related cognitive impairment.
558 citations
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TL;DR: It is found that healthy never-smoker females achieve full lung growth earlier than males, and their rate of decline with age was slightly, but not significantly, lower, and there is a range of susceptibility to the effects of smoking.
Abstract: Rationale: Understanding normal lung development and aging in health and disease, both in men and in women, is essential to interpreting any therapeutic intervention.Objectives: We aimed to describe lung function changes in healthy never-smoking males and females, from adolescence to old age, and to determine the effects of smoking and those derived from quitting.Methods: Prospective cohort study within all participants of the Framingham Offspring cohort who had two or more valid spirometry measurements during follow-up (n = 4,391; age range at baseline 13 to 71 yr), with a median follow-up time of 23 years.Measurements and Main Results: To best fit the curves describing FEV1 changes with age to raw data, we used a generalized additive model with smooth terms and incorporating the subject-specific (longitudinal) random effects. We found that: (1) healthy never-smoker females achieve full lung growth earlier than males, and their rate of decline with age was slightly, but not significantly, lower; (2) smok...
557 citations
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TL;DR: It is established that a genetic network controlling the phosphate stress response influences the structure of the root microbiome community, even under non-stress phosphate conditions, and that the master transcriptional regulators of phosphate Stress Response in Arabidopsis thaliana directly repress defence, consistent with plant prioritization of nutritional stress over defence.
Abstract: Plants live in biogeochemically diverse soils with diverse microbiota. Plant organs associate intimately with a subset of these microbes, and the structure of the microbial community can be altered by soil nutrient content. Plant-associated microbes can compete with the plant and with each other for nutrients, but may also carry traits that increase the productivity of the plant. It is unknown how the plant immune system coordinates microbial recognition with nutritional cues during microbiome assembly. Here we establish that a genetic network controlling the phosphate stress response influences the structure of the root microbiome community, even under non-stress phosphate conditions. We define a molecular mechanism regulating coordination between nutrition and defence in the presence of a synthetic bacterial community. We further demonstrate that the master transcriptional regulators of phosphate stress response in Arabidopsis thaliana also directly repress defence, consistent with plant prioritization of nutritional stress over defence. Our work will further efforts to define and deploy useful microbes to enhance plant performance.
557 citations
Authors
Showing all 44305 results
Name | H-index | Papers | Citations |
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Mark P. Mattson | 200 | 980 | 138033 |
Carlo M. Croce | 198 | 1135 | 189007 |
Charles A. Dinarello | 190 | 1058 | 139668 |
Richard A. Gibbs | 172 | 889 | 249708 |
Gang Chen | 167 | 3372 | 149819 |
David A. Bennett | 167 | 1142 | 109844 |
Carl W. Cotman | 165 | 809 | 105323 |
Rodney S. Ruoff | 164 | 666 | 194902 |
David Tilman | 158 | 340 | 149473 |
David Cella | 156 | 1258 | 106402 |
Richard E. Smalley | 153 | 494 | 111117 |
Deepak L. Bhatt | 149 | 1973 | 114652 |
Kevin Murphy | 146 | 728 | 120475 |
Jian Yang | 142 | 1818 | 111166 |
Thomas J. Smith | 140 | 1775 | 113919 |