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Institution

University of Kerala

EducationThiruvananthapuram, India
About: University of Kerala is a education organization based out in Thiruvananthapuram, India. It is known for research contribution in the topics: Raman spectroscopy & Adsorption. The organization has 3945 authors who have published 4737 publications receiving 69920 citations.


Papers
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Journal ArticleDOI
TL;DR: This review focuses on the status of all these approaches in generating a "super curcumin," a homodimer of feruloylmethane containing a methoxy group and a hydroxyl group, a heptadiene with two Michael acceptors, and an alpha,beta-diketone.

1,095 citations

Journal ArticleDOI
TL;DR: Curcumin III is the most active of the curcuminoids present in turmeric, indicated by the ability of these compounds to suppress the superoxide production by macrophages activated with phorbol-12-myristate-13-acetate (PMA).

1,082 citations

Journal ArticleDOI
TL;DR: This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.
Abstract: New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive “smart” MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasound (US), or can even be responsive to dual or multi-combinations of different stimuli. This unparalleled capability has increased their importance as site-specific controlled drug delivery systems (DDSs) and has encouraged their rapid development in recent years. An in-depth understanding of the underlying mechanisms of these DDS approaches is expected to further contribute to this groundbreaking field of nanomedicine. Smart nanocarriers in the form of MNPs that can be triggered by internal or external stimulus are summarized and discussed in the present review, including pH-sensitive peptides and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (NPs), mechanical- or electrical-responsive MNPs, light or ultrasound-sensitive particles, and multi-responsive MNPs including dual stimuli-sensitive nanosheets of graphene. This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.

1,072 citations

Journal ArticleDOI
TL;DR: Semiconductor quantum dots and metal nanoparticles have extensive applications, e.g., in vitro and in vivo bioimaging, and toxic effects of NPs and their clearance from the body are discussed.
Abstract: We review the syntheses, optical properties, and biological applications of cadmium selenide (CdSe) and cadmium selenide-zinc sulfide (CdSe-ZnS) quantum dots (QDs) and gold (Au) and silver (Ag) nanoparticles (NPs). Specifically, we selected the syntheses of QDs and Au and Ag NPs in aqueous and organic phases, size- and shape-dependent photoluminescence (PL) of QDs and plasmon of metal NPs, and their bioimaging applications. The PL properties of QDs are discussed with reference to their band gap structure and various electronic transitions, relations of PL and photoactivated PL with surface defects, and blinking of single QDs. Optical properties of Ag and Au NPs are discussed with reference to their size- and shape-dependent surface plasmon bands, electron dynamics and relaxation, and surface-enhanced Raman scattering (SERS). The bioimaging applications are discussed with reference to in vitro and in vivo imaging of live cells, and in vivo imaging of cancers, tumor vasculature, and lymph nodes. Other aspects of the review are in vivo deep tissue imaging, multiphoton excitation, NIR fluorescence and SERS imaging, and toxic effects of NPs and their clearance from the body.

490 citations

Journal ArticleDOI
TL;DR: In this paper, the effect of diverse ions has been studied and it is found that there is very little effect on the adsorption of Cr(VI) on polymer-grafted sawdust.

454 citations


Authors

Showing all 3989 results

NameH-indexPapersCitations
M. Santosh103134449846
Howard A. Bern7138718037
Thanu Padmanabhan6848624870
Venugopal P. Menon5419510111
T.S. Anirudhan471146395
Daizy Philip441017576
Vasudevanpillai Biju441566854
William H. Wilson431836057
Manoj Pandey402344932
Susan Mathew371276492
Danaboyina Ramaiah371174188
I. Hubert Joe361804511
V. P. N. Nampoori353305200
Roy J. Mathew331143967
R. B. Rakhi33635229
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202321
202267
2021445
2020354
2019253
2018242