Institution
University of Kiel
Education•Kiel, Germany•
About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.
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TL;DR: There is an exciting increase of evidence that members of the disintegrin and metalloprotease (ADAM) family critically regulate cell adhesion, migration, development and signalling.
389 citations
TL;DR: In situ observations of microhabitat preferences of living benthic foraminifera are presented from sediments of the Norwegian-Greenland Sea, the upwelling area off northwestern Africa and the shallow-water Kiel Bight, and flexible behaviour is regarded as a dynamic adaptation to optimize food acquisition.
388 citations
TL;DR: It is hypothesize that specific inhibition of the trans-signaling pathway may be superior to global blockade of IL-6 activity with help of antibodies directed against IL- 6 or IL-7R.
388 citations
TL;DR: In this paper, aeolo-marine dust deposits in the subtropical eastern Atlantic were analyzed to evaluate the strength of the major wind patterns during the late Quaternary to give an insight into the climate of North Africa.
Abstract: Analysis of aeolo-marine dust deposits in the subtropical eastern Atlantic enables the strength of the major wind patterns during the late Quaternary to be evaluated and gives an insight into the climate of North Africa.
387 citations
Hannover Medical School1, Bernhard Nocht Institute for Tropical Medicine2, University of California, San Francisco3, University of Veterinary Medicine Vienna4, Systems Research Institute5, University of Kiel6, University of Freiburg7, University of Giessen8, University of Marburg9, University of Erlangen-Nuremberg10, University of Bonn11
TL;DR: It was found that recombinant SARS-S bound to ACE2 and induced ACE2 shedding with higher efficiency than NL63-S and replicated efficiently in ACE2-positive Vero cells and reduced ACE2 expression, indicating robust receptor interference in the context of SARS but not NL63 infection.
Abstract: The human coronaviruses (CoVs) severe acute respiratory syndrome (SARS)-CoV and NL63 employ angiotensin-converting enzyme 2 (ACE2) for cell entry. It was shown that recombinant SARS-CoV spike protein (SARS-S) downregulates ACE2 expression and thereby promotes lung injury. Whether NL63-S exerts a similar activity is yet unknown. We found that recombinant SARS-S bound to ACE2 and induced ACE2 shedding with higher efficiency than NL63-S. Shedding most likely accounted for the previously observed ACE2 downregulation but was dispensable for viral replication. Finally, SARS-CoV but not NL63 replicated efficiently in ACE2-positive Vero cells and reduced ACE2 expression, indicating robust receptor interference in the context of SARS-CoV but not NL63 infection.
387 citations
Authors
Showing all 28103 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Stefan Schreiber | 178 | 1233 | 138528 |
| Jun Wang | 166 | 1093 | 141621 |
| William J. Sandborn | 162 | 1317 | 108564 |
| Jens Nielsen | 149 | 1752 | 104005 |
| Tak W. Mak | 148 | 807 | 94871 |
| Annette Peters | 138 | 1114 | 101640 |
| Severine Vermeire | 134 | 1086 | 76352 |
| Peter M. Rothwell | 134 | 779 | 67382 |
| Dusan Bruncko | 132 | 1042 | 84709 |
| Gideon Bella | 129 | 1301 | 87905 |
| Dirk Schadendorf | 127 | 1017 | 105777 |
| Neal L. Benowitz | 126 | 792 | 60658 |
| Thomas Schwarz | 123 | 701 | 54560 |
| Meletios A. Dimopoulos | 122 | 1371 | 71871 |
| Christian Weber | 122 | 776 | 53842 |