Institution
University of Kiel
Education•Kiel, Germany•
About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.
Papers published on a yearly basis
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TL;DR: In this article, the first minimum of the logarithm of the generalized correlation integral C1(τ) provides an easily evaluable criterion for the proper choice of the time delay τ that is needed to reconstruct the trajectory in phase space from chaotic scalar time series data.
310 citations
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TL;DR: The role of different ecological factors on the evolution of immunity is examined by contextualizing the main ecological factors, including interactions with parasites, other types of biotic as well as abiotic interactions, intraspecific selective constraints (life-history trade-offs, sexual selection) and population genetic processes.
Abstract: An organism's fitness is critically reliant on its immune system to provide protection against parasites and pathogens. The structure of even simple immune systems is surprisingly complex and clearly will have been moulded by the organism's ecology. The aim of this review and the theme issue is to examine the role of different ecological factors on the evolution of immunity. Here, we will provide a general framework of the field by contextualizing the main ecological factors, including interactions with parasites, other types of biotic as well as abiotic interactions, intraspecific selective constraints (life-history trade-offs, sexual selection) and population genetic processes. We then elaborate the resulting immunological consequences such as the diversity of defence mechanisms (e.g. avoidance behaviour, resistance, tolerance), redundancy and protection against immunopathology, life-history integration of the immune response and shared immunity within a community (e.g. social immunity and microbiota-mediated protection). Our review summarizes the concepts of current importance and directs the reader to promising future research avenues that will deepen our understanding of the defence against parasites and pathogens.
310 citations
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Wellcome Trust Sanger Institute1, University of Oslo2, Oslo University Hospital3, University of Kiel4, Norwich University5, Max Planck Society6, University of Groningen7, Hannover Medical School8, University of Calgary9, University of Toronto10, National Institute for Health Research11, University of Barcelona12, Mayo Clinic13, Pomeranian Medical University14, Ludwig Maximilian University of Munich15, University of Hamburg16, Charité17, University of Cambridge18, University of Thessaly19, University of Bonn20, Technische Universität München21, University of California, Berkeley22, University of Mainz23, University of Alberta24, University of Helsinki25, National Institutes of Health26, Sapienza University of Rome27, University of Padua28, University of Virginia29, University of California, San Diego30, University of Lübeck31, Norwegian University of Science and Technology32, Katholieke Universiteit Leuven33, Queen Mary University of London34, Akershus University Hospital35, Mount Sinai Hospital, Toronto36, University of Pittsburgh37, Karolinska University Hospital38, Casa Sollievo della Sofferenza39, Cleveland Clinic Lerner Research Institute40, Cleveland Clinic41, University of Paris42, University of California, Davis43, Université de Montréal44, Montreal Heart Institute45, Yale University46
TL;DR: This analysis compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip to identify 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16.
Abstract: Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.
309 citations
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01 Jan 2000
TL;DR: Versteht man unter „Routinelabor“ das Anforderungsprofil, das unabhangig von Anamnese und klinischem Befund bei jedem Patienten mit zunachst unbekannter Diagnose oder unbeknter Komplikation eines Patienten with bekannter diagnosis sinnvoll und notwendig ist, so sind vereinfacht zwei Situationen zu unterscheiden:
Abstract: Versteht man unter „Routinelabor“ das Anforderungsprofil, das unabhangig von Anamnese und klinischem Befund bei jedem Patienten mit zunachst unbekannter Diagnose oder unbekannter Komplikation eines Patienten mit bekannter Diagnose sinnvoll und notwendig ist, so sind vereinfacht zwei Situationen zu unterscheiden:
309 citations
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TL;DR: In this article, a follow-up study of the 235 most significant SNPs in 1,105 affected individuals and 873 controls replicated the disease association of SNP A-1791411 in ABCG8 (allelic P value PCCA = 4.1 × 10−9).
Abstract: With an overall prevalence of 10–20%, gallstone disease (cholelithiasis) represents one of the most frequent and economically relevant health problems of industrialized countries1,2. We performed an association scan of >500,000 SNPs in 280 individuals with gallstones and 360 controls. A follow-up study of the 235 most significant SNPs in 1,105 affected individuals and 873 controls replicated the disease association of SNP A-1791411 in ABCG8 (allelic P value PCCA = 4.1 × 10−9), which was subsequently attributed to coding variant rs11887534 (D19H). Additional replication was achieved in 728 German (P = 2.8 × 10−7) and 167 Chilean subjects (P = 0.02). The overall odds ratio for D19H carriership was 2.2 (95% confidence interval: 1.8–2.6, P = 1.4 × 10−14) in the full German sample. Association was stronger in subjects with cholesterol gallstones (odds ratio = 3.3), suggesting that His19 might be associated with a more efficient transport of cholesterol into the bile.
309 citations
Authors
Showing all 28103 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stefan Schreiber | 178 | 1233 | 138528 |
Jun Wang | 166 | 1093 | 141621 |
William J. Sandborn | 162 | 1317 | 108564 |
Jens Nielsen | 149 | 1752 | 104005 |
Tak W. Mak | 148 | 807 | 94871 |
Annette Peters | 138 | 1114 | 101640 |
Severine Vermeire | 134 | 1086 | 76352 |
Peter M. Rothwell | 134 | 779 | 67382 |
Dusan Bruncko | 132 | 1042 | 84709 |
Gideon Bella | 129 | 1301 | 87905 |
Dirk Schadendorf | 127 | 1017 | 105777 |
Neal L. Benowitz | 126 | 792 | 60658 |
Thomas Schwarz | 123 | 701 | 54560 |
Meletios A. Dimopoulos | 122 | 1371 | 71871 |
Christian Weber | 122 | 776 | 53842 |