Institution
University of Kiel
Education•Kiel, Germany•
About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.
Papers published on a yearly basis
Papers
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TL;DR: The pathology and biology of the various NETs and NECs of the gastrointestinal tract (including the oesophagus) and the pancreas are reviewed.
Abstract: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are composed of cells with a neuroendocrine phenotype. The old and the new WHO classifications distinguish between well-differentiated and poorly differentiated neoplasms. All well-differentiated neoplasms, regardless of whether they behave benignly or develop metastases, will be called neuroendocrine tumours (NETs), and graded G1 (Ki67 20%). To stratify the GEP-NETs and GEP-NECs regarding their prognosis, they are now further classified according to TNM-stage systems that were recently proposed by the European Neuroendocrine Tumour Society (ENETS) and the AJCC/UICC. In the light of these criteria the pathology and biology of the various NETs and NECs of the gastrointestinal tract (including the oesophagus) and the pancreas are reviewed.
290 citations
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TL;DR: Six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A are identified and the heterogeneity of disease susceptibility between the Chinese and European populations is highlighted.
Abstract: We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10⁻³ and P = 7.9 × 10⁻³, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10⁻³ and P = 1.5 × 10⁻³, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.
290 citations
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TL;DR: In this article, the authors present a new method that is relatively simple, and could be advantageous in some cases, involving the employment and proper interpretation of low amplitude variable frequency AC measurements, a general technique that is often called impedance spectroscopy.
Abstract: In materials that are of interest for use as solid electrolytes it is important that charge transport is predominantly related to ionic motion, with minimal minority electronic conduction. On the other hand, a number of materials are mixed ionic and electronic conductors. Several DC methods that have been developed over many years to evaluate the separate electronic and ionic components of the total charge transport in solids. These include the Tubandt DC method, the DC assymetric polarization technique sometimes called the Hebb-Wagner method, and the DC open circuit potential method. This paper presents a new method that is relatively simple, and could be advantageous in some cases. It involves the employment and proper interpretation of low amplitude variable frequency AC measurements, a general technique that is often called impedance spectroscopy. As an example, the results of the use of this method on a mixed-conducting perovskite related to the well-known LSGM, La0.4Pr0.4Sr0.2In0.8Mg0.2O2.8, are shown.
290 citations
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TL;DR: It is demonstrated that copepods can be highly adept at breaking up their own pellets while ingesting only a small proportion, a behaviour the authors define as “coprorhexy” and speculate on the nutritional value of such a behaviour and the possible significance of “ghost” pellets, consisting of a membrane with little or no apparent solid content.
Abstract: Copepod faecal pellets have often been considered as rapid transporters of material out of the euphotic zone. Laboratory experiments on their degradation and sinking rates support this view, but field data on the distribution and flux of pellets through the water colomn present contradictory evidence. We suggest that due to the exclusion of metazoans from previously published degradation experiments, such studies may have little relevance to the natural environments. In 1987/1988 we carried out experiments using adult copepods of mixed species but dominated byCentropages hamatus collected in Kiel Bight (FRG). We have demonstrated that copepods can be highly adept at breaking up their own pellets while ingesting only a small proportion, a behaviour we define as “coprorhexy”. The microbiota is probably unable to cause significant modification to faecal pellets before they are fragmented within a few hours of their production. Thereafter, microbial remineralisation will become important. Many of the “difficult” field data can be readily explained if the process of coprorhexy is taken into account and, indeed, breakage of large particles by crustacean zooplankton may be an important process in modifying material transport in the ocean. Copepods appear to perform coprorhexy by removing the peritrophic membrane with its attached bacterial flora and this may then be ingested. We speculate on the nutritional value of such a behaviour and the possible significance of “ghost” pellets, consisting of a membrane with little or no apparent solid content.
290 citations
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TL;DR: It is shown that inhibition of cathepsin K could potently suppress autoimmune inflammation of the joints as well as osteoclastic bone resorption in autoimmune arthritis and mice were resistant to experimental autoimmune encephalomyelitis.
Abstract: Cathepsin K was originally identified as an osteoclast-specific lysosomal protease, the inhibitor of which has been considered might have therapeutic potential. We show that inhibition of cathepsin K could potently suppress autoimmune inflammation of the joints as well as osteoclastic bone resorption in autoimmune arthritis. Furthermore, cathepsin K–/– mice were resistant to experimental autoimmune encephalomyelitis. Pharmacological inhibition or targeted disruption of cathepsin K resulted in defective Toll-like receptor 9 signaling in dendritic cells in response to unmethylated CpG DNA, which in turn led to attenuated induction of T helper 17 cells, without affecting the antigen-presenting ability of dendritic cells. These results suggest that cathepsin K plays an important role in the immune system and may serve as a valid therapeutic target in autoimmune diseases.
289 citations
Authors
Showing all 28103 results
Name | H-index | Papers | Citations |
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Stefan Schreiber | 178 | 1233 | 138528 |
Jun Wang | 166 | 1093 | 141621 |
William J. Sandborn | 162 | 1317 | 108564 |
Jens Nielsen | 149 | 1752 | 104005 |
Tak W. Mak | 148 | 807 | 94871 |
Annette Peters | 138 | 1114 | 101640 |
Severine Vermeire | 134 | 1086 | 76352 |
Peter M. Rothwell | 134 | 779 | 67382 |
Dusan Bruncko | 132 | 1042 | 84709 |
Gideon Bella | 129 | 1301 | 87905 |
Dirk Schadendorf | 127 | 1017 | 105777 |
Neal L. Benowitz | 126 | 792 | 60658 |
Thomas Schwarz | 123 | 701 | 54560 |
Meletios A. Dimopoulos | 122 | 1371 | 71871 |
Christian Weber | 122 | 776 | 53842 |