University of Kiel

About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Crystal structure. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.

Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma.

Abstract: BackgroundMany patients with severe asthma rely on oral glucocorticoids to manage their disease We investigated whether benralizumab, a monoclonal antibody directed against the alpha subunit of the interleukin-5 receptor that significantly reduces the incidence of asthma exacerbations, was also effective as an oral glucocorticoid–sparing therapy in patients relying on oral glucocorticoids to manage severe asthma associated with eosinophilia MethodsIn a 28-week randomized, controlled trial, we assessed the effects of benralizumab (at a dose of 30 mg administered subcutaneously either every 4 weeks or every 8 weeks [with the first three doses administered every 4 weeks]) versus placebo on the reduction in the oral glucocorticoid dose while asthma control was maintained in adult patients with severe asthma The primary end point was the percentage change in the oral glucocorticoid dose from baseline to week 28 Annual asthma exacerbation rates, lung function, symptoms, and safety were assessed ResultsOf 3

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Abstract: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.

Trade-offs between multifunctionality and profit in tropical smallholder landscapes

Abstract: Land-use transitions can enhance the livelihoods of smallholder farmers but potential economic-ecological trade-offs remain poorly understood. Here, we present an interdisciplinary study of the environmental, social and economic consequences of land-use transitions in a tropical smallholder landscape on Sumatra, Indonesia. We find widespread biodiversity-profit trade-offs resulting from land-use transitions from forest and agroforestry systems to rubber and oil palm monocultures, for 26,894 aboveground and belowground species and whole-ecosystem multidiversity. Despite variation between ecosystem functions, profit gains come at the expense of ecosystem multifunctionality, indicating far-reaching ecosystem deterioration. We identify landscape compositions that can mitigate trade-offs under optimal land-use allocation but also show that intensive monocultures always lead to higher profits. These findings suggest that, to reduce losses in biodiversity and ecosystem functioning, changes in economic incentive structures through well-designed policies are urgently needed.

Limitations of Voltage-Oriented PI Current Control of Grid-Connected PWM Rectifiers With $LCL$ Filters

Abstract: Voltage-oriented PI control of three-phase grid-connected pulsewidth-modulation rectifiers with LCL filters is addressed. LCL filters require resonance damping. Active resonance damping is state of the art to face the problem, but it is still under investigation because of the manifold solutions. It is often realized using many sensors and/or complex control algorithms. In contrast, pure PI control requires only one set of current sensors, and its implementation and design are rather simple and well known from the L filter control. PI control has already been shown to be a suitable solution also for LCL filters, but there are limitations. These are investigated in this paper. System stability is analyzed with respect to different ratios of LCL filter resonance and control frequencies. The latter are important parameters for system design and control. Both line and converter current control are analyzed. For a certain range of frequency ratios, the voltage-oriented PI control gives stable performance without additional feedback, but for ratios outside this range, stable operation is impossible. Experimental tests validate the theoretical results. In addition, an experimentally determined LCL filter transfer function is shown in this paper, which shows a lower resonance peak as expected from commonly used filter models.