Institution
University of Kiel
Education•Kiel, Germany•
About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.
Papers published on a yearly basis
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TL;DR: It is shown that keratinocytes secrete, as the main E. coli–killing compound, the S100 protein psoriasin in vitro and in vivo in a site-dependent way, and this protein may be key to the resistance of skin against E coli.
Abstract: Human healthy skin is continuously exposed to bacteria, but is particularly resistant to the common gut bacterium Escherichia coli. We show here that keratinocytes secrete, as the main E. coli-killing compound, the S100 protein psoriasin in vitro and in vivo in a site-dependent way. In vivo treatment of human skin with antibodies to psoriasin inhibited its E. coli-killing properties. Psoriasin was induced in keratinocytes in vitro and in vivo by E. coli, indicating that its focal expression in skin may derive from local microbial induction. Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli.
642 citations
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TL;DR: In this paper, Li5La3M2O12 (M = Nb, Ta), possessing a garnet-like structure, has been investigated with regard to their electrical properties.
Abstract: Lithium metal oxides with the nominal composition Li5La3M2O12 (M = Nb, Ta), possessing a garnetlike structure, have been investigated with regard to their electrical properties. These compounds form a new class of solid-state lithium ion conductors with a different crystal structure compared with all those known so far. The materials are prepared by solid-state reaction and characterized by powder XRD and ac impedance to determine their lithium ionic conductivity. Both the niobium and tantalum members exhibit the same order of magnitude of bulk conductivity (∼10−6 S/cm at 25°C). The activation energies for ionic conductivity (<300°C) are 0.43 and 0.56 eV for Li5La3Nb2O12 and Li5La3Ta2O12, respectively, which are comparable to those of other solid lithium conductors, such as Lisicon, Li14ZnGe4O16. Among the investigated materials, the tantalum compound Li5La3Ta2O12 is stable against reaction with molten lithium. Further tailoring of the compositions by appropriate chemical substitutions and improved synthesizing methods, especially with regard to minimizing grain-boundary resistance, are important issues in view of the potential use of the new class of compounds as electrolytes in practical lithium ion batteries.
640 citations
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TL;DR: This Review describes the development of curcumin from a "traditional" spice and food coloring to a "modern" biological regulator.
Abstract: Turmeric is traditionally used as a spice and coloring in foods. It is an important ingredient in curry and gives curry powder its characteristic yellow color. As a consequence of its intense yellow color, turmeric, or curcumin (food additive E100), is used as a food coloring (e.g. mustard). Turmeric contains the curcuminoids curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Recently, the health properties (neuroprotection, chemo-, and cancer prevention) of curcuminoids have gained increasing attention. Curcuminoids induce endogenous antioxidant defense mechanisms in the organism and have anti-inflammatory activity. Curcuminoids influence gene expression as well as epigenetic mechanisms. Synthetic curcumin analogues also exhibit biological activity. This Review describes the development of curcumin from a "traditional" spice and food coloring to a "modern" biological regulator.
639 citations
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TL;DR: Psoriasis patients appear to be at higher risk for diabetes mellitus and cardiovascular disease, which could likely be due to the effects of chronic inflammatory changes, in particular the secretion of proinflammatory cytokines.
Abstract: The role of chronic inflammation causing metabolic and vascular disorders is increasingly recognized. It is hypothesized that proinflammatory cytokines contribute to atherogenesis, peripheral insulin resistance, and the development of hypertension and type II diabetes. Psoriasis as a chronic inflammatory skin disorder is characterized by a variety of immunologic and inflammatory changes and may similarly predispose for those disorders. The objective of this study was to elucidate the association of psoriasis with chronic vascular and metabolic disorders. We investigated a total of 581 adult patients hospitalised for plaque type psoriasis as compared to 1,044 hospital-based controls. A distinct pattern of chronic disorders was found to be significantly associated with psoriasis, including diabetes mellitus type II [odds ratio (OR)=2.48], arterial hypertension (OR = 3.27), hyperlipedemia (OR = 2.09), and coronary heart disease (OR = 1.95). The combined presence of these conditions together with obesity, known as the metabolic syndrome, was clearly more prevalent in psoriasis patients (OR = 5.29). In addition, psoriasis patients were significantly more likely to be smokers (OR = 2.96) and to have a regular or heavy consumption of alcohol (OR = 3.33 and 3.61, respectively). In conclusion, psoriasis patients appear to be at higher risk for diabetes mellitus and cardiovascular disease. This could likely be due to the effects of chronic inflammatory changes, in particular the secretion of proinflammatory cytokines. The risk of late term cardiovascular complications might support the use of systemic treatment in psoriasis.
638 citations
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Charité1, Oregon Health & Science University2, French Institute of Health and Medical Research3, University of Western Australia4, King Edward Memorial Hospital5, Sanford Health6, Children's Hospital of Eastern Ontario7, University of Toronto8, University of Cambridge9, University College London10, Cold Spring Harbor Laboratory11, Queen Mary University of London12, Radboud University Nijmegen13, Wellcome Trust Sanger Institute14, Katholieke Universiteit Leuven15, Johns Hopkins University School of Medicine16, University of Kiel17, University of Pennsylvania18, University of Luxembourg19, Medical College of Wisconsin20, Newcastle University21, Tohoku University22, Manchester Royal Eye Hospital23, John Radcliffe Hospital24, University of Sydney25, University of Miami26, Garvan Institute of Medical Research27, Lawrence Berkeley National Laboratory28, University of Connecticut29
TL;DR: The progress of the HPO project is reviewed, including specific areas of expansion such as common (complex) disease, new algorithms for phenotype driven genomic discovery and diagnostics, integration of cross-species mapping efforts with the Mammalian Phenotype Ontology, an improved quality control pipeline, and the addition of patient-friendly terminology.
Abstract: Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described. The three components of the Human Phenotype Ontology (HPO; www.human-phenotype-ontology.org) project are the phenotype vocabulary, disease-phenotype annotations and the algorithms that operate on these. These components are being used for computational deep phenotyping and precision medicine as well as integration of clinical data into translational research. The HPO is being increasingly adopted as a standard for phenotypic abnormalities by diverse groups such as international rare disease organizations, registries, clinical labs, biomedical resources, and clinical software tools and will thereby contribute toward nascent efforts at global data exchange for identifying disease etiologies. This update article reviews the progress of the HPO project since the debut Nucleic Acids Research database article in 2014, including specific areas of expansion such as common (complex) disease, new algorithms for phenotype driven genomic discovery and diagnostics, integration of cross-species mapping efforts with the Mammalian Phenotype Ontology, an improved quality control pipeline, and the addition of patient-friendly terminology.
638 citations
Authors
Showing all 28103 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stefan Schreiber | 178 | 1233 | 138528 |
Jun Wang | 166 | 1093 | 141621 |
William J. Sandborn | 162 | 1317 | 108564 |
Jens Nielsen | 149 | 1752 | 104005 |
Tak W. Mak | 148 | 807 | 94871 |
Annette Peters | 138 | 1114 | 101640 |
Severine Vermeire | 134 | 1086 | 76352 |
Peter M. Rothwell | 134 | 779 | 67382 |
Dusan Bruncko | 132 | 1042 | 84709 |
Gideon Bella | 129 | 1301 | 87905 |
Dirk Schadendorf | 127 | 1017 | 105777 |
Neal L. Benowitz | 126 | 792 | 60658 |
Thomas Schwarz | 123 | 701 | 54560 |
Meletios A. Dimopoulos | 122 | 1371 | 71871 |
Christian Weber | 122 | 776 | 53842 |