Institution
University of Kiel
Education•Kiel, Germany•
About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.
Papers published on a yearly basis
Papers
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University of Copenhagen1, Smithsonian Tropical Research Institute2, Rafael Advanced Defense Systems3, University of Utah4, University of California, Berkeley5, University of Sydney6, Texas A&M University7, Missouri State University8, Spanish National Research Council9, Uppsala University10, University of California, Los Angeles11, University of Alberta12, Mount Holyoke College13, University of Leeds14, University of Bristol15, Russian Academy of Sciences16, University of Oregon17, Moscow State University18, China University of Geosciences (Wuhan)19, University of Kansas20, National Park Service21, American Museum of Natural History22, Aarhus University23, Regierungspräsidium Stuttgart24, University of Kiel25, University of Oslo26, University of Adelaide27, University of York28, Pennsylvania State University29
TL;DR: It is shown that climate has been a major driver of population change over the past 50,000 years, however, each species responds differently to the effects of climatic shifts, habitat redistribution and human encroachment.
Abstract: Despite decades of research, the roles of climate and humans in driving the dramatic extinctions of large-bodied mammals during the Late Quaternary period remain contentious. Here we use ancient DNA, species distribution models and the human fossil record to elucidate how climate and humans shaped the demographic history of woolly rhinoceros, woolly mammoth, wild horse, reindeer, bison and musk ox. We show that climate has been a major driver of population change over the past 50,000 years. However, each species responds differently to the effects of climatic shifts, habitat redistribution and human encroachment. Although climate change alone can explain the extinction of some species, such as Eurasian musk ox and woolly rhinoceros, a combination of climatic and anthropogenic effects appears to be responsible for the extinction of others, including Eurasian steppe bison and wild horse. We find no genetic signature or any distinctive range dynamics distinguishing extinct from surviving species, emphasizing the challenges associated with predicting future responses of extant mammals to climate and human-mediated habitat change.
582 citations
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TL;DR: This paper provides a systematic approach to the design of filter-based active damping methods with tuning procedures, performance, robustness, and limitations discussed with theoretical analysis, selected simulation, and experimental results.
Abstract: Pulsewidth modulation (PWM) voltage source converters are becoming a popular interface to the power grid for many applications. Hence, issues related to the reduction of PWM harmonics injection in the power grid are becoming more relevant. The use of high-order filters like LCL filters is a standard solution to provide the proper attenuation of PWM carrier and sideband voltage harmonics. However, those grid filters introduce potentially unstable dynamics that should be properly damped either passively or actively. The second solution suffers from control and system complexity (a high number of sensors and a high-order controller), even if it is more attractive due to the absence of losses in the damping resistors and due to its flexibility. An interesting and straightforward active damping solution consists in plugging in, in cascade to the main controller, a filter that should damp the unstable dynamics. No more sensors are needed, but there are open issues such as preserving the bandwidth, robustness, and limited complexity. This paper provides a systematic approach to the design of filter-based active damping methods. The tuning procedures, performance, robustness, and limitations of the different solutions are discussed with theoretical analysis, selected simulation, and experimental results.
580 citations
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TL;DR: In this article, the core aggregates having a diameter range of 100-200 nm are extremely tight and could not be broken up by any known method of de-aggregation.
579 citations
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Tohoku University1, University of Kiel2, Wayne State University3, LSU Health Sciences Center Shreveport4, Johns Hopkins University5, Japanese Foundation for Cancer Research6, Memorial Sloan Kettering Cancer Center7, Dartmouth–Hitchcock Medical Center8, Saitama Medical University9, Osaka Medical College10, Kagoshima University11
TL;DR: A consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type are defined and can be used for further analyses of the clinicopathological significance of the variations of IPMN.
Abstract: Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN.
577 citations
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TL;DR: A genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry finds a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Abstract: Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
576 citations
Authors
Showing all 28103 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stefan Schreiber | 178 | 1233 | 138528 |
Jun Wang | 166 | 1093 | 141621 |
William J. Sandborn | 162 | 1317 | 108564 |
Jens Nielsen | 149 | 1752 | 104005 |
Tak W. Mak | 148 | 807 | 94871 |
Annette Peters | 138 | 1114 | 101640 |
Severine Vermeire | 134 | 1086 | 76352 |
Peter M. Rothwell | 134 | 779 | 67382 |
Dusan Bruncko | 132 | 1042 | 84709 |
Gideon Bella | 129 | 1301 | 87905 |
Dirk Schadendorf | 127 | 1017 | 105777 |
Neal L. Benowitz | 126 | 792 | 60658 |
Thomas Schwarz | 123 | 701 | 54560 |
Meletios A. Dimopoulos | 122 | 1371 | 71871 |
Christian Weber | 122 | 776 | 53842 |