Institution
University of Kiel
Education•Kiel, Germany•
About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.
Papers published on a yearly basis
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King's College London1, Wellcome Trust Sanger Institute2, University of Cambridge3, University of Greifswald4, University of Lübeck5, University of Leicester6, University of Ottawa7, University of Pennsylvania8, National Institutes of Health9, University of Helsinki10, Broad Institute11, Harvard University12, European Bioinformatics Institute13, MedStar Washington Hospital Center14, Cambridge University Hospitals NHS Foundation Trust15, Imperial College London16, Children's Hospital of Philadelphia17, Leeds General Infirmary18, University of Regensburg19, GlaxoSmithKline20, Lund University21, Helsinki University Central Hospital22, Technische Universität München23, University of Kiel24, University of Washington25, Ludwig Maximilian University of Munich26, Queen Mary University of London27
TL;DR: A long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction is identified and it is shown that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
Abstract: The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
504 citations
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TL;DR: The Greenland Ice Sheet Project 2 (GISP2) depth-age scale is presented based on a multiparameter continuous count approach to a depth of 2800 m, using a systematic combination of parameters that have never been used to this extent before as mentioned in this paper.
Abstract: The Greenland Ice Sheet Project 2 (GISP2) depth-age scale is presented based on a multiparameter continuous count approach, to a depth of 2800 m, using a systematic combination of parameters that have never been used to this extent before. The ice at 2800 m is dated at 110,000 years B.P. with an estimated error ranging from 1 to 10% in the top 2500 m of the core and averaging 20% between 2500 and 2800 m. Parameters used to date the core include visual stratigraphy, oxygen isotopic ratios of the ice, electrical conductivity measurements, laser-light scattering from dust, volcanic signals, and major ion chemistry. GISP2 ages for major climatic events agree with independent ages based on varve chronologies, calibrated radiocarbon dates, and other techniques within the combined uncertainties. Good agreement also is obtained with Greenland Ice Core Project ice core dates and with the SPECMAP marine timescale after correlation through the δ 18 O of O 2 . Although the core is deformed below 2800 m and the continuity of the record is unclear, we attempted to date this section of the core on the basis of the laser-light scattering of dust in the ice.
502 citations
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TL;DR: Genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci identify other important points of host–microbe intersection, notably several disease susceptibility genes and sterol metabolism pathway components.
Abstract: Human gut microbiota is an important determinant for health and disease, and recent studies emphasize the numerous factors shaping its diversity. Here we performed a genome-wide association study (GWAS) of the gut microbiota using two cohorts from northern Germany totaling 1,812 individuals. Comprehensively controlling for diet and non-genetic parameters, we identify genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D receptor). We observe significant shifts in the microbiota of Vdr-/- mice relative to control mice and correlations between the microbiota and serum measurements of selected bile and fatty acids in humans, including known ligands and downstream metabolites of VDR. Genome-wide significant (P < 5 × 10-8) associations at multiple additional loci identify other important points of host-microbe intersection, notably several disease susceptibility genes and sterol metabolism pathway components. Non-genetic and genetic factors each account for approximately 10% of the variation in gut microbiota, whereby individual effects are relatively small.
501 citations
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TL;DR: The abundance of plastics in stomachs of northern fulmars from the North Sea is used in the OSPAR Ecological Quality Objective (EcoQO) for marine litter and is now also used as an indicator for Good Environmental Status in the European Marine Strategy Framework Directive.
499 citations
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TL;DR: In this article, the active damping approaches for PI-based current control of grid-connected PWM converters with LCL filters are analyzed and compared in the continuous Laplace domain.
Abstract: This paper deals with various active damping approaches for PI-based current control of grid-connected pulsewidth-modulation (PWM) converters with LCL filters, which are based on one additional feedback. Filter capacitor current, as well as voltage feedback for the purpose of resonance damping, are analyzed and compared. Basic studies in the continuous Laplace domain show that either proportional current feedback or derivative voltage feedback yields resonance damping. Detailed investigations of these two approaches in the discrete z-domain, taking into account the discrete nature of control implementation, sampling, and PWM, are carried out. Several ratios of LCL resonance frequency and control frequency are considered. At high resonance frequencies, only current feedback stabilizes the system. At medium resonance frequencies, both approaches have good performance. At low resonance frequencies, stability gets worse, even though voltage feedback offers slightly better damping properties. Measurements validate the theoretical results.
499 citations
Authors
Showing all 28103 results
Name | H-index | Papers | Citations |
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Stefan Schreiber | 178 | 1233 | 138528 |
Jun Wang | 166 | 1093 | 141621 |
William J. Sandborn | 162 | 1317 | 108564 |
Jens Nielsen | 149 | 1752 | 104005 |
Tak W. Mak | 148 | 807 | 94871 |
Annette Peters | 138 | 1114 | 101640 |
Severine Vermeire | 134 | 1086 | 76352 |
Peter M. Rothwell | 134 | 779 | 67382 |
Dusan Bruncko | 132 | 1042 | 84709 |
Gideon Bella | 129 | 1301 | 87905 |
Dirk Schadendorf | 127 | 1017 | 105777 |
Neal L. Benowitz | 126 | 792 | 60658 |
Thomas Schwarz | 123 | 701 | 54560 |
Meletios A. Dimopoulos | 122 | 1371 | 71871 |
Christian Weber | 122 | 776 | 53842 |