University of Kiel

About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Crystal structure. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.

The genome of Chenopodium quinoa

Abstract: Chenopodium quinoa (quinoa) is a highly nutritious grain identified as an important crop to improve world food security. Unfortunately, few resources are available to facilitate its genetic improvement. Here we report the assembly of a high-quality, chromosome-scale reference genome sequence for quinoa, which was produced using single-molecule real-time sequencing in combination with optical, chromosome-contact and genetic maps. We also report the sequencing of two diploids from the ancestral gene pools of quinoa, which enables the identification of sub-genomes in quinoa, and reduced-coverage genome sequences for 22 other samples of the allotetraploid goosefoot complex. The genome sequence facilitated the identification of the transcription factor likely to control the production of anti-nutritional triterpenoid saponins found in quinoa seeds, including a mutation that appears to cause alternative splicing and a premature stop codon in sweet quinoa strains. These genomic resources are an important first step towards the genetic improvement of quinoa.

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Abstract: To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). Through imputation and mixed-model association analysis in 12,577 cases and 23,475 controls, combined with 2,579 cases and 2,767 controls in an independent replication cohort, we fine-mapped a new risk locus on chromosome 21 and identified C21orf2 as a gene associated with ALS risk. In addition, we identified MOBP and SCFD1 as new associated risk loci. We established evidence of ALS being a complex genetic trait with a polygenic architecture. Furthermore, we estimated the SNP-based heritability at 8.5%, with a distinct and important role for low-frequency variants (frequency 1-10%). This study motivates the interrogation of larger samples with full genome coverage to identify rare causal variants that underpin ALS risk.

The formation of a bound star cluster: from the orion nebula cluster to the pleiades

Abstract: Summary Direct N-body calculations are presented of the formation of Galactic clusters using GasEx, which is a variant of the code Nbody6. The calculations focus on the possible evolution of the Orion Nebula Cluster (ONC) by assuming that the embedded OB stars explosively drove out 2/3 of its mass in the form of gas about 0.4 Myr ago. A bound cluster forms readily and survives for 150 Myr despite additional mass loss from the large number of massive stars, and the Galactic tidal field. This is the very first time that cluster formation is obtained under such realistic conditions. The cluster contains about 1/3 of the initial 10 4 stars, and resembles the Pleiades Cluster to a remarkable degree, implying that an ONC-like cluster may have been a precursor of the Pleiades. This scenario predicts the present expansion velocity of the ONC, which will be measurable by upcoming astrometric space missions. These missions should also detect the original Pleiades members as an associated expanding young Galactic-field sub-population. The results arrived at here suggest that Galactic clusters form as the nuclei of expanding OB associations. The results have wide implications, also for the formation of globular clusters and the Galactic field and halo stellar populations. In view of this, the distribution of binary orbital periods and the mass function within and outside the model ONC and Pleiades is quantified, finding consistency with observational constraints. Advanced mass segregation is evident in one of the ONC models. The calculations show that the primordial binary population of both clusters could have been much the same as is observed in the Taurus–Auriga star forming region. The computations also demonstrate that the binary proportion of brown dwarfs is depleted significantly for all periods, whereas massive stars attain a high binary fraction.

The pathophysiology of tremor

Abstract: Tremor is defined as rhythmic oscillatory activity of body parts. Four physiological basic mechanisms for such oscillatory activity have been described: mechanical oscillations; oscillations based on reflexes; oscillations due to central neuronal pacemakers; and oscillations because of disturbed feedforward or feedback loops. New methodological approaches with animal models, positron emission tomography, and mathematical analysis of electromyographic and electroencephalographic signals have provided new insights into the mechanisms underlying specific forms of tremor. Physiological tremor is due to mechanical and central components. Psychogenic tremor is considered to depend on a clonus mechanism and is thus believed to be mediated by reflex mechanisms. Symptomatic palatal tremor is most likely due to rhythmic activity of the inferior olive, and there is much evidence that essential tremor is also generated within the olivocerebellar circuits. Orthostatic tremor is likely to originate in hitherto unidentified brainstem nuclei. Rest tremor of Parkinson's disease is probably generated in the basal ganglia loop, and dystonic tremor may also originate within the basal ganglia. Cerebellar tremor is at least in part caused by a disturbance of the cerebellar feedforward control of voluntary movements, and Holmes' tremor is due to the combination of the mechanisms producing parkinsonian and cerebellar tremor. Neuropathic tremor is believed to be caused by abnormally functioning reflex pathways and a wide variety of causes underlies toxic and drug-induced tremors. The understanding of the pathophysiology of tremor has made significant progress but many hypotheses are not yet based on sufficient data. Modern neurology needs to develop and test such hypotheses, because this is the only way to develop rational medical and surgical therapies.