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Institution

University of Konstanz

EducationKonstanz, Baden-Württemberg, Germany
About: University of Konstanz is a education organization based out in Konstanz, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Visualization. The organization has 12115 authors who have published 27401 publications receiving 951162 citations. The organization is also known as: University of Constance & Universität Konstanz.


Papers
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Journal ArticleDOI
TL;DR: It is shown that a neutral particle with an electric dipole moment which moves in a magnetic field acquires a topological phase which may be observed in atom or molecular interferometry.
Abstract: It is shown that a neutral particle with an electric dipole moment which moves in a magnetic field acquires a topological phase. This phase may be observed in atom or molecular interferometry.

249 citations

Journal ArticleDOI
TL;DR: The crystal structures of CD1b in complex with either phosphatidylinositol or ganglioside GM2 at 2.3 Å and 2.8 Å resolutions reveal the mechanism by which two alkyl chain lipids bind toCD1b, and how CD1 b can adapt to ligands of different alkyal chain length.
Abstract: The human genome encodes five nonpolymorphic major histocompatibility complex class I-like glycoproteins, CD1a to CD1e, that present lipid antigens for specific recognition by T lymphocytes. Using single alkyl chain detergents, we developed a protocol to generate recombinant human CD1b-lipid complexes. We present here the crystal structures of CD1b in complex with either phosphatidylinositol or ganglioside GM2 at 2.3 A and 2.8 A resolutions, respectively. The antigen-binding groove houses four interlinked hydrophobic channels that are occupied by the alkyl chains of the glycolipid plus two detergent molecules. A distinct exit beneath the alpha 2 helix further contributes to the plasticity of the binding groove. These structures reveal the mechanism by which two alkyl chain lipids bind to CD1b, and how CD1b can adapt to ligands of different alkyl chain length. They also suggest how very long alkyl chains, such as those of mycolic acid, could be fully contained within the binding groove. These results extend the spectrum of potential CD1b ligands by revealing that, in addition to two alkyl chain lipids, mono-alkyl and triple-alkyl chain lipids can be accommodated in the binding groove.

249 citations

Journal ArticleDOI
TL;DR: The authors evaluate empirically how, in the course of globalization, partisan politics affected social expenditures in a panel of OECD countries, and investigate its interaction with the KOF index of globalization.
Abstract: This paper evaluates empirically how, in the course of globalization, partisan politics affected social expenditures in a panel of OECD countries. I introduce an updated indicator of government ideology and investigate its interaction with the KOF index of globalization. Two basic results emerge: First, at times when globalization proceeded at an average pace, partisan politics had no effect on social expenditures, but leftist governments increased social expenditures when globalization was proceeding rapidly. Second, policies differed in the 1980s and 1990s: Leftist governments pursued expansionary policies in the 1980s. Yet partisan politics disappeared in the 1990s, but not because of globalization.

249 citations

Journal ArticleDOI
Klaus Sattler1, J. Mühlbach1, Olof Echt1, P. Pfau1, Ekkehard Recknagel1 
TL;DR: In this paper, mass spectra of Pb, NaI, and Xe microclusters were analyzed and it was shown that below a critical number of atoms per cluster, doubly charged particles are not stable.
Abstract: Mass spectra of Pb, NaI, and Xe microclusters show that below a critical number of atoms per cluster, ${n}^{**}$, doubly charged particles are not stable. These numbers are 30 for ${\mathrm{Pb}}_{n}$, 20 for ${(\mathrm{NaI})}_{n}$ and 52 for ${\mathrm{Xe}}_{n}$. The two positive charges generated at one atom by electron bombardment are likely to move to opposite sides of the cluster which then explodes into singly charged fragments as long as the Coulomb repulsion energy is greater than the binding energy.

249 citations

Journal ArticleDOI
TL;DR: Comparison of the interaction of two S100 proteins, S100B and S100A6, with RAGE by in vitro assay and in culture of human SH-SY5Y neuroblastoma cells suggests that the receptor for advanced glycation end products (RAGE) plays important roles in mediating S100 protein-induced cellular signaling.

249 citations


Authors

Showing all 12272 results

NameH-indexPapersCitations
Robert E. W. Hancock15277588481
Lloyd J. Old152775101377
Andrew White1491494113874
Stefanie Dimmeler14757481658
Rudolf Amann14345985525
Niels Birbaumer14283577853
Thomas P. Russell141101280055
Emmanuelle Perez138155099016
Shlomo Havlin131101383347
Bruno S. Frey11990065368
Roald Hoffmann11687059470
Michael G. Fehlings116118957003
Yves Van de Peer11549461479
Axel Meyer11251151195
Manuela Campanelli11167548563
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202360
2022202
20211,361
20201,299
20191,166
20181,082