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Institution

University of Konstanz

EducationKonstanz, Baden-Württemberg, Germany
About: University of Konstanz is a education organization based out in Konstanz, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Visualization. The organization has 12115 authors who have published 27401 publications receiving 951162 citations. The organization is also known as: University of Constance & Universität Konstanz.


Papers
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Journal ArticleDOI
TL;DR: A forward scheme for simulating backward SDEs is introduced that avoids high order nestings of conditional expectations backwards in time and an implementable algorithm is presented and its convergence is proved.

228 citations

Journal ArticleDOI
TL;DR: Estuarine species show a higher and more flexible capacity for photoprotection than oceanic and coastal species, and when exposed to excess light, the impairment of their photosynthetic capacity because of photoinhibition was reduced, resulting in maintenance of growth in a fluctuating light regime.
Abstract: In this study, we show a fundamental difference between diatom species from different marine habitats in their ability to cope with changes in irradiance. Estuarine species show a higher and more flexible capacity for photoprotection than oceanic and coastal species, and when exposed to excess light, the impairment of their photosynthetic capacity because of photoinhibition was reduced. This resulted in maintenance of growth in a fluctuating light regime, conferring the estuarine species an adaptive advantage. The ability of diatoms, and to a larger extent other phytoplankton, to occupy a wide range of ecological niches depends critically on their capacity to exploit the differences in underwater light climate. These results might explain how diatoms adapt to the challenge of maintaining optimal photosynthetic production in turbulent waters, in which the rate of light change is high.

228 citations

Journal ArticleDOI
TL;DR: It is reported that p66Shc−/− mice are resistant to hyperglycemia-induced, ROS-dependent endothelial dysfunction and may represent a novel therapeutic target against diabetic vascular complications.
Abstract: Increased production of reactive oxygen species (ROS) and loss of endothelial NO bioavailability are key features of vascular disease in diabetes mellitus. The p66Shc adaptor protein controls cellular responses to oxidative stress. Mice lacking p66Shc (p66Shc−/−) have increased resistance to ROS and prolonged life span. The present work was designed to investigate hyperglycemia-associated changes in endothelial function in a model of insulin-dependent diabetes mellitus p66Shc−/− mouse. p66Shc−/− and wild-type (WT) mice were injected with citrate buffer (control) or made diabetic by an i.p. injection of 200 mg of streptozotocin per kg of body weight. Streptozotocin-treated p66Shc−/− and WT mice showed a similar increase in blood glucose. However, significant differences arose with respect to endothelial dysfunction and oxidative stress. WT diabetic mice displayed marked impairment of endothelium-dependent relaxations, increased peroxynitrite (ONOO−) generation, nitrotyrosine expression, and lipid peroxidation as measured in the aortic tissue. In contrast, p66Shc−/− diabetic mice did not develop these high-glucose-mediated abnormalities. Furthermore, protein expression of the antioxidant enzyme heme oxygenase 1 and endothelial NO synthase were up-regulated in p66Shc−/− but not in WT mice. We report that p66Shc−/− mice are resistant to hyperglycemia-induced, ROS-dependent endothelial dysfunction. These data suggest that p66Shc adaptor protein is part of a signal transduction pathway relevant to hyperglycemia vascular damage and, hence, may represent a novel therapeutic target against diabetic vascular complications.

228 citations

Journal ArticleDOI
TL;DR: In this article, the authors used meta-analysis techniques to test whether 18 lakes in northern, western, and central Europe respond coherently to winter climate forcing, and to assess the persistence of the winter climate signal in physical, chemical, and biological variables during the year.
Abstract: Recent studies have highlighted the impact of the winter North Atlantic Oscillation (NAO) on water temperature, ice conditions, and spring plankton phenology in specific lakes and regions in Europe. Here, we use meta-analysis techniques to test whether 18 lakes in northern, western, and central Europe respond coherently to winter climate forcing, and to assess the persistence of the winter climate signal in physical, chemical, and biological variables during the year. A meta-analysis approach was chosen because we wished to emphasize the overall coherence pattern rather than individual lake responses. A particular strength of our approach is that time-series from each of the 18 lakes were subjected to the same robust statistical analysis covering the same 23-year period. Although the strongest overall coherence in response to the winter NAO was exhibited by lake water temperatures, a strong, coherent response was also exhibited by concentrations of soluble reactive phosphorus and soluble reactive silicate, most likely as a result of the coherent response exhibited by the spring phytoplankton bloom. Lake nitrate concentrations showed significant coherence in winter. With the exception of the cyanobacterial biomass in summer, phytoplankton biomass in all seasons was unrelated to the winter NAO. A strong coherence in the abundance of daphnids during spring can most likely be attributed to coherence in daphnid phenology. A strong coherence in the summer abundance of the cyclopoid copepods may have been related to a coherent change in their emergence from resting stages. We discuss the complex nature of the potential mechanisms that drive the observed changes.

228 citations

Journal ArticleDOI
TL;DR: To verify the efficiency of two different water treatment systems with respect to reduction of cyanobacterial toxins, the concentrations of MC in water samples from surface waters and their associated water treatment plants in Switzerland and Germany were investigated.

228 citations


Authors

Showing all 12272 results

NameH-indexPapersCitations
Robert E. W. Hancock15277588481
Lloyd J. Old152775101377
Andrew White1491494113874
Stefanie Dimmeler14757481658
Rudolf Amann14345985525
Niels Birbaumer14283577853
Thomas P. Russell141101280055
Emmanuelle Perez138155099016
Shlomo Havlin131101383347
Bruno S. Frey11990065368
Roald Hoffmann11687059470
Michael G. Fehlings116118957003
Yves Van de Peer11549461479
Axel Meyer11251151195
Manuela Campanelli11167548563
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202360
2022202
20211,361
20201,299
20191,166
20181,082