University of Konstanz

About: University of Konstanz is a education organization based out in Konstanz, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Membrane. The organization has 12115 authors who have published 27401 publications receiving 951162 citations. The organization is also known as: University of Constance & Universität Konstanz.

In Search of Co‐variance, Causal Mechanisms or Congruence? Towards a Plural Understanding of Case Studies

Abstract: Methodological reflections about case study research have increased within recent years. According to our account, there are three distinct approaches to case studies: co-variational, causal process tracing, and congruence analysis. The main goals of this article are to lay out the distinct ways in which causal inferences are drawn for the cases under study and to scrutinize the different understandings and directions of generalization within these three approaches. By doing so we highlight two aspects: First, causal process tracing and congruence analysis should be seen as two distinct alternatives to the dominant co-variational template. Second, the main characteristics of case studies, their thickness, provides only an unavoidable dilemma if we aim to generalize the findings towards a wider population of similar cases as in the co-variational template. If we would like to get deeper insights â-“ as the causal process tracing approach does â-“ or if we would like to use the empirical evidence for a broader theoretical discourse â-“ as the congruence analysis does â-“ case studies do not face a trade-off.

Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains.

Abstract: Reggie-1 and -2 proteins (flotillin-2 and -1 respectively) form their own type of non-caveolar membrane microdomains, which are involved in important cellular processes such as T-cell activation, phagocytosis and signalling mediated by the cellular prion protein and insulin; this is consistent with the notion that reggie microdomains promote protein assemblies and signalling. While it is generally known that membrane microdomains contain large multiprotein assemblies, the exact organization of reggie microdomains remains elusive. Using chemical cross-linking approaches, we have demonstrated that reggie complexes are composed of homo- and hetero-tetramers of reggie-1 and -2. Moreover, native reggie oligomers are indeed quite stable, since non-cross-linked tetramers are resistant to 8 M urea treatment. We also show that oligomerization requires the C-terminal but not the N-terminal halves of reggie-1 and -2. Using deletion constructs, we analysed the functional relevance of the three predicted coiled-coil stretches present in the C-terminus of reggie-1. We confirmed experimentally that reggie-1 tetramerization is dependent on the presence of coiled-coil 2 and, partially, of coiled-coil 1. Furthermore, since depletion of reggie-1 by siRNA (small interfering RNA) silencing induces proteasomal degradation of reggie-2, we conclude that the protein stability of reggie-2 depends on the presence of reggie-1. Our data indicate that the basic structural units of reggie microdomains are reggie homo- and hetero-tetramers, which are dependent on the presence of reggie-1.

Crafting Trust The Role of Political Institutions in a Comparative Perspective

Abstract: In this article, the authors evaluate the origins of generalized trust. In addition to examining individual-level determinants, the analytic focus is on the political-institutional context. In cont...

Intensive language training enhances brain plasticity in chronic aphasia.

Abstract: Focal clusters of slow wave activity in the delta frequency range (1–4 Hz), as measured by magnetencephalography (MEG), are usually located in the vicinity of structural damage in the brain. Such oscillations are usually considered pathological and indicative of areas incapable of normal functioning owing to deafferentation from relevant input sources. In the present study we investigated the change in Delta Dipole Density in 28 patients with chronic aphasia (>12 months post onset) following cerebrovascular stroke of the left hemisphere before and after intensive speech and language therapy (3 hours/day over 2 weeks). Neuropsychologically assessed language functions improved significantly after training. Perilesional delta activity decreased after therapy in 16 of the 28 patients, while an increase was evident in 12 patients. The magnitude of change of delta activity in these areas correlated with the amount of change in language functions as measured by standardized language tests. These results emphasize the significance of perilesional areas in the rehabilitation of aphasia even years after the stroke, and might reflect reorganisation of the language network that provides the basis for improved language functions after intensive training.