Institution
University of Konstanz
Education•Konstanz, Baden-Württemberg, Germany•
About: University of Konstanz is a education organization based out in Konstanz, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Visualization. The organization has 12115 authors who have published 27401 publications receiving 951162 citations. The organization is also known as: University of Constance & Universität Konstanz.
Topics: Population, Visualization, Membrane, Visual analytics, Silicon
Papers published on a yearly basis
Papers
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Stellenbosch University1, Academy of Sciences of the Czech Republic2, Charles University in Prague3, Canterbury of New Zealand4, University of Tennessee5, University of Fribourg6, University College London7, Zoological Society of London8, Williams College9, Durham University10, University of Vienna11, South African National Parks12, International Union for Conservation of Nature and Natural Resources13, Free University of Berlin14, Leibniz Association15, Martin Luther University of Halle-Wittenberg16, Helmholtz Centre for Environmental Research - UFZ17, United States Forest Service18, Czech University of Life Sciences Prague19, University of Toronto20, University of Rhode Island21, University of Concepción22, Taizhou University23, University of Konstanz24, Spanish National Research Council25, University of Seville26, University of Pretoria27
TL;DR: Improved international cooperation is crucial to reduce the impacts of invasive alien species on biodiversity, ecosystem services, and human livelihoods, as synergies with other global changes are exacerbating current invasions and facilitating new ones, thereby escalating the extent and impacts of invaders.
Abstract: Biological invasions are a global consequence of an increasingly connected world and the rise in human population size The numbers of invasive alien species – the subset of alien species that spread widely in areas where they are not native, affecting the environment or human livelihoods – are increasing Synergies with other global changes are exacerbating current invasions and facilitating new ones, thereby escalating the extent and impacts of invaders Invasions have complex and often immense long‐term direct and indirect impacts In many cases, such impacts become apparent or problematic only when invaders are well established and have large ranges Invasive alien species break down biogeographic realms, affect native species richness and abundance, increase the risk of native species extinction, affect the genetic composition of native populations, change native animal behaviour, alter phylogenetic diversity across communities, and modify trophic networks Many invasive alien species also change ecosystem functioning and the delivery of ecosystem services by altering nutrient and contaminant cycling, hydrology, habitat structure, and disturbance regimes These biodiversity and ecosystem impacts are accelerating and will increase further in the future Scientific evidence has identified policy strategies to reduce future invasions, but these strategies are often insufficiently implemented For some nations, notably Australia and New Zealand, biosecurity has become a national priority There have been long‐term successes, such as eradication of rats and cats on increasingly large islands and biological control of weeds across continental areas However, in many countries, invasions receive little attention Improved international cooperation is crucial to reduce the impacts of invasive alien species on biodiversity, ecosystem services, and human livelihoods Countries can strengthen their biosecurity regulations to implement and enforce more effective management strategies that should also address other global changes that interact with invasions
677 citations
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TL;DR: The analysis of the cellular compartmentation of elements in the Zn hyperaccumulator Arabidopsis halleri indicates that the mesophyll cells in the leaves of A. halleri are the major storage site for Zn and Cd, and play an important role in theirhyperaccumulation.
Abstract: The cellular compartmentation of elements was analysed in the Zn hyperaccumulator Arabidopsis halleri (L.) O'Kane & Al-Shehbaz (=Cardaminopsis halleri) using energy-dispersive X-ray microanalysis of frozen-hydrated tissues. Quantitative data were obtained using oxygen as an internal standard in the analyses of vacuoles, whereas a peak/background ratio method was used for quantification of elements in pollen and dehydrated trichomes. Arabidopsis halleri was found to hyperaccumulate not only Zn but also Cd in the shoot biomass. While large concentrations of Zn and Cd were found in the leaves and roots, flowers contained very little. In roots grown hydroponically, Zn and Cd accumulated in the cell wall of the rhizodermis (root epidermis), mainly due to precipitation of Zn/Cd phosphates. In leaves, the trichomes had by far the largest concentrations of Zn and Cd. Inside the trichomes there was a striking sub-cellular compartmentation, with almost all the Zn and Cd being accumulated in a narrow ring in the trichome base. This distribution pattern was very different from that for Ca and P. The epidermal cells other than trichomes were very small and contained lower concentrations of Zn and Cd than mesophyll cells. In particular, the concentrations of Cd and Zn in the mesophyll cells increased markedly in response to increasing Zn and Cd concentrations in the nutrient solution. This indicates that the mesophyll cells in the leaves of A. halleri are the major storage site for Zn and Cd, and play an important role in their hyperaccumulation.
674 citations
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Van Andel Institute1, Arizona State University2, University of Southern California3, SLAC National Accelerator Laboratory4, National University of Singapore5, Scripps Research Institute6, University of California, Los Angeles7, University of Toronto8, Vanderbilt University9, University of Wisconsin–Milwaukee10, Chinese Academy of Sciences11, Paul Scherrer Institute12, Trinity College, Dublin13, University of Chicago14, University of Konstanz15
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Abstract: G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent pathways. Here we report the crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin, determined by serial femtosecond X-ray laser crystallography. Together with extensive biochemical and mutagenesis data, the structure reveals an overall architecture of the rhodopsin-arrestin assembly in which rhodopsin uses distinct structural elements, including transmembrane helix 7 and helix 8, to recruit arrestin. Correspondingly, arrestin adopts the pre-activated conformation, with a similar to 20 degrees rotation between the amino and carboxy domains, which opens up a cleft in arrestin to accommodate a short helix formed by the second intracellular loop of rhodopsin. This structure provides a basis for understanding GPCR-mediated arrestin-biased signalling and demonstrates the power of X-ray lasers for advancing the frontiers of structural biology.
672 citations
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TL;DR: The data suggest that chronic pain is accompanied by cortical reorganization and may serve an important function in the persistence of the pain experience.
669 citations
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TL;DR: In this paper, the authors describe a bacteria that can oxidize colourless Fe(u) to brown Fe(in) and reduce CO2 to cell material, implying that oxygen-independent biological iron oxidation was possible before the evolution of oxygenic photosynthesis.
Abstract: NATURAL oxidation of ferrous to ferric iron by bacteria such as Thiobacillus ferrooxidans or Gallionella ferruginea1, or by chemical oxidation2,3 has previously been thought always to involve molecular oxygen as the electron acceptor. Anoxic photochemical reactions4–6 or a photobiological process involving two photosystems7–9 have also been discussed as mechanisms of ferrous iron oxidation. The knowledge of such processes has implications that bear on our understanding of the origin of Precambrian banded iron formations10–14. The reducing power of ferrous iron increases dramatically at pH values higher than 2–3 owing to the formation of ferric hydroxy and oxyhydroxy compounds1,2,15 (Fig. 1). The standard redox potential of Fe3+/Fe2+ (E0 = +0.77 V) is relevant only under acidic conditions. At pH 7.0, the couples Fe(OH)3/Fe2+ (E′0 = -0.236V) or Fe(OH)3 + HCO−3FeCO3 (E′0 = +0.200 V) prevail, matching redox potentials measured in natural sediments9,16,17. It should thus be possible for Fe(n) around pH 7.0 to function as an electron donor for anoxygenic photosynthesis. The midpoint potential of the reaction centre in purple bacteria is around +0.45 V (ref. 18). Here we describe purple, non-sulphur bacteria that can indeed oxidize colourless Fe(u) to brown Fe(in) and reduce CO2 to cell material, implying that oxygen-independent biological iron oxidation was possible before the evolution of oxygenic photosynthesis.
667 citations
Authors
Showing all 12272 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert E. W. Hancock | 152 | 775 | 88481 |
Lloyd J. Old | 152 | 775 | 101377 |
Andrew White | 149 | 1494 | 113874 |
Stefanie Dimmeler | 147 | 574 | 81658 |
Rudolf Amann | 143 | 459 | 85525 |
Niels Birbaumer | 142 | 835 | 77853 |
Thomas P. Russell | 141 | 1012 | 80055 |
Emmanuelle Perez | 138 | 1550 | 99016 |
Shlomo Havlin | 131 | 1013 | 83347 |
Bruno S. Frey | 119 | 900 | 65368 |
Roald Hoffmann | 116 | 870 | 59470 |
Michael G. Fehlings | 116 | 1189 | 57003 |
Yves Van de Peer | 115 | 494 | 61479 |
Axel Meyer | 112 | 511 | 51195 |
Manuela Campanelli | 111 | 675 | 48563 |