Institution
University of Konstanz
Education•Konstanz, Baden-Württemberg, Germany•
About: University of Konstanz is a education organization based out in Konstanz, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Membrane. The organization has 12115 authors who have published 27401 publications receiving 951162 citations. The organization is also known as: University of Constance & Universität Konstanz.
Topics: Population, Membrane, Politics, Laser, Gene
Papers published on a yearly basis
Papers
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TL;DR: Histochemical staining and comparative activity determination of succinate dehydrogenase in single fibres revealed that the mosaic like fibre composition of the fast muscle was transformed into a more uniform population resembling that of a predominantly slow muscle.
Abstract: Intermittant long-term stimulation of fast rabbit muscles up to 28 days with a frequency pattern resembling that of a slow muscle (10 Imp/sec) led to a slowing of the time course of contraction already during the first week. There was an increase of tetanic tension as well. The observed rearrangement of activities of key enzymes of energy supplying metabolism was found to occur sequentially. Decreases of extramitochondrial enzymes of glycogenolysis (phosphorylase), glycolysis (triosephosphate dehydrogenase, lactate dehydrogenase) and energy rich phosphate transfer were found initially together with a decrease of mitochondrial glycerolphosphate dehydrogenase. The isozyme pattern of lactate dehydrogenase was changed. Large initial increases were found in enzymes involved in glucose phosphorylation (hexokinase) and fatty acid activation (palmitoyl-CoA synthetase). Later an increase of key enzymes of the citric acid cycle (citrate synthase) and fatty acid oxidation (3-hydroxyacyl-CoA dehydrogenase) as well as ketone body utilization (3-ketoacid-CoA transferase) could be shown. Histochemical staining and comparative activity determination of succinate dehydrogenase in single fibres revealed that the mosaic like fibre composition of the fast muscle was transformed into a more uniform population resembling that of a predominantly slow muscle.
386 citations
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TL;DR: A fusion protein between cyclophilin-D and glutathione S-transferase (GST) was shown to bind to purified liver inner mitochondrial membranes (IMMs) in a cyclosporin A (CsA)-sensitive manner and was enhanced by diamide treatment of the IMMs.
Abstract: A fusion protein between cyclophilin-D (CyP-D) and glutathione S-transferase (GST) was shown to bind to purified liver inner mitochondrial membranes (IMMs) in a cyclosporin A (CsA)-sensitive manner. Binding was enhanced by diamide treatment of the IMMs. Immobilized GST-CyP-D avidly bound a single 30 kDa protein present in Triton X-100-solubilized IMMs; immunoblotting showed this to be the adenine nucleotide translocase (ANT). Binding was prevented by pretreatment of the CyP-D with CsA, but not with cyclosporin H. Purified ANT also bound specifically to GST-CyP-D, but porin did not, even in the presence of ANT.
383 citations
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Centre national de la recherche scientifique1, Foundation for Research & Technology – Hellas2, Université libre de Bruxelles3, University of Salamanca4, Autonomous University of Madrid5, University of Paris6, Instituto Gulbenkian de Ciência7, Goethe University Frankfurt8, Ludwig Maximilian University of Munich9, University of Manchester10, Pasteur Institute11, Université catholique de Louvain12, Royal Children's Hospital13, French Institute of Health and Medical Research14, John Radcliffe Hospital15, VU University Amsterdam16, University of Konstanz17, Carlsberg Laboratory18, University of Wrocław19
TL;DR: The complete DNA sequence of the yeast Saccharomyces cerevisiae chromosome XI has been determined, and the 666,448-base-pair sequence has revealed general chromosome patterns.
Abstract: The complete DNA sequence of the yeast Saccharomyces cerevisiae chromosome XI has been determined. In addition to a compact arrangement of potential protein coding sequences, the 666,448-base-pair sequence has revealed general chromosome patterns; in particular, alternating regional variations in average base composition correlate with variations in local gene density along the chromosome. Significant discrepancies with the previously published genetic map demonstrate the need for using independent physical mapping criteria.
383 citations
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University of Vienna1, Stellenbosch University2, Zoological Society of London3, University College London4, International Union for Conservation of Nature and Natural Resources5, Lincoln University (Pennsylvania)6, Free University of Berlin7, Leibniz Association8, University of Auckland9, Academy of Sciences of the Czech Republic10, Charles University in Prague11, University of Konstanz12, Taizhou University13, Kwame Nkrumah University of Science and Technology14, National and Kapodistrian University of Athens15, University of Fribourg16, University of Oldenburg17, Scion18, University of Sassari19, University of Porto20, Universidade Nova de Lisboa21, Charles Darwin Foundation22, Durham University23, Okinawa Institute of Science and Technology24, University of Concepción25, University of Hong Kong26, CABI27, Helmholtz Centre for Environmental Research - UFZ28, Martin Luther University of Halle-Wittenberg29, United States Forest Service30, Bielefeld University31, University of Bern32, Botanical Society of Britain and Ireland33, Environment Agency34, Smithsonian Institution35, Institut national de la recherche agronomique36, University of Silesia in Katowice37, Landcare Research38, National Agriculture and Food Research Organization39
TL;DR: Using a global database of the first regional records of alien species covering the years 1500–2005, a surprisingly high proportion of species in recent records that have never been recorded as alien before are detected.
Abstract: Our ability to predict the identity of future invasive alien species is largely based upon knowledge of prior invasion history Emerging alien species—those never encountered as aliens before—therefore pose a significant challenge to biosecurity interventions worldwide Understanding their temporal trends, origins, and the drivers of their spread is pivotal to improving prevention and risk assessment tools Here, we use a database of 45,984 first records of 16,019 established alien species to investigate the temporal dynamics of occurrences of emerging alien species worldwide Even after many centuries of invasions the rate of emergence of new alien species is still high: One-quarter of first records during 2000–2005 were of species that had not been previously recorded anywhere as alien, though with large variation across taxa Model results show that the high proportion of emerging alien species cannot be solely explained by increases in well-known drivers such as the amount of imported commodities from historically important source regions Instead, these dynamics reflect the incorporation of new regions into the pool of potential alien species, likely as a consequence of expanding trade networks and environmental change This process compensates for the depletion of the historically important source species pool through successive invasions We estimate that 1–16% of all species on Earth, depending on the taxonomic group, qualify as potential alien species These results suggest that there remains a high proportion of emerging alien species we have yet to encounter, with future impacts that are difficult to predict
382 citations
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TL;DR: A three-tissue organ-on-a-chip system, comprised of liver, heart, and lung, is described, and the value of multiple tissue integration for in vitro study of both the efficacy of and side effects associated with candidate drugs is illustrated.
Abstract: Many drugs have progressed through preclinical and clinical trials and have been available – for years in some cases – before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation from drug candidate to successful use is a lack of model systems that accurately recapitulate normal tissue function of human organs and their response to drug compounds. Moreover, tissues in the body do not exist in isolation, but reside in a highly integrated and dynamically interactive environment, in which actions in one tissue can affect other downstream tissues. Few engineered model systems, including the growing variety of organoid and organ-on-a-chip platforms, have so far reflected the interactive nature of the human body. To address this challenge, we have developed an assortment of bioengineered tissue organoids and tissue constructs that are integrated in a closed circulatory perfusion system, facilitating inter-organ responses. We describe a three-tissue organ-on-a-chip system, comprised of liver, heart, and lung, and highlight examples of inter-organ responses to drug administration. We observe drug responses that depend on inter-tissue interaction, illustrating the value of multiple tissue integration for in vitro study of both the efficacy of and side effects associated with candidate drugs.
382 citations
Authors
Showing all 12272 results
Name | H-index | Papers | Citations |
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Robert E. W. Hancock | 152 | 775 | 88481 |
Lloyd J. Old | 152 | 775 | 101377 |
Andrew White | 149 | 1494 | 113874 |
Stefanie Dimmeler | 147 | 574 | 81658 |
Rudolf Amann | 143 | 459 | 85525 |
Niels Birbaumer | 142 | 835 | 77853 |
Thomas P. Russell | 141 | 1012 | 80055 |
Emmanuelle Perez | 138 | 1550 | 99016 |
Shlomo Havlin | 131 | 1013 | 83347 |
Bruno S. Frey | 119 | 900 | 65368 |
Roald Hoffmann | 116 | 870 | 59470 |
Michael G. Fehlings | 116 | 1189 | 57003 |
Yves Van de Peer | 115 | 494 | 61479 |
Axel Meyer | 112 | 511 | 51195 |
Manuela Campanelli | 111 | 675 | 48563 |