University of Konstanz

About: University of Konstanz is a education organization based out in Konstanz, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Membrane. The organization has 12115 authors who have published 27401 publications receiving 951162 citations. The organization is also known as: University of Constance & Universität Konstanz.

Lipopolysaccharide and ceramide docking to CD14 provokes ligand‐specific receptor clustering in rafts

Abstract: The glycosylphosphatidylinositol-anchored receptor CD14 plays a major role in the inflammatory response of monocytes to lipopolysaccharide. Here, we describe that ceramide, a constituent of atherogenic lipoproteins, binds to CD14 and induces clustering of CD14 to co-receptors in rafts. In resting cells, CD14 was associated with CD55, the Fcgamma-receptors CD32 and CD64 and the pentaspan CD47. Ceramide further recruited the complement receptor 3 (CD11b/CD18) and CD36 into proximity of CD14. Lipopolysaccharide, in addition, induced co-clustering with Toll-like receptor 4, Fcgamma-RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated. The different receptor complexes may be linked to ligand-specific cellular responses initiated by CD14.

User modeling and user-adapted interaction

Abstract: User modeling has made considerable progress during its existence now of more than a decade. Particularly in the last few years, the need has been recognized in many application areas for software systems to automatically adapt to their current users. As a result, research on user modeling has extended into many disciplines which are concerned with the development of interactive computer systems that are used by heterogeneous user populations. These fields include Intelligent Interfaces, Active and Passive Help Systems, Guidance Systems, Hypertext Systems, Intelligent Information Retrieval, Natural-Language Systems, Intelligent Tutoring Systems, and Cooperative Expert Systems. Applications in office machines, consumer electronics and automobiles are also being envisioned. Several recent empirical evaluations provide support for the usefulness of user-adaptation in the investigated application domains.

Magnetic order and fluctuations in superconducting UPt3.

Abstract: Neutron diffraction shows that superconducting ${\mathrm{UPt}}_{3}$ can be an antiferromagnet with an ordered moment of (0.02\ifmmode\pm\else\textpm\fi{}0.01)${\mathrm{\ensuremath{\mu}}}_{\mathrm{B}}$ and a N\'eel temperature (${\mathrm{T}}_{\mathrm{N}}$) of 5 K. The squared order parameter is linear function of temperature from ${\mathrm{T}}_{\mathrm{N}}$ to the superconducting transition temperature, ${\mathrm{T}}_{\mathrm{c}}$=0.5 K, below which it ceases to evolve. Inelastic neutron scattering demonstrates that the fluctuating moments are strongly correlated; the characteristic energy for fluctuations with wave vectors close to the ordering wave vector is 0.2 meV\ensuremath{\approxeq}4${\mathrm{kT}}_{\mathrm{c}}$..AE