Showing papers by "University of Lausanne published in 1973"
TL;DR: In this article, LiOCMe3 impurities were used for carboxylation yielding 2-naphthaleneacetic acid, which was characterized with Me3SiCl as PhCH2SiMe3.
Abstract: Treating PhMe with BuLi in the presence of KOCMe3 gave PhCH2K, which on LiBr treatment was converted into 85% PhCH2Li, characterized with Me3SiCl as PhCH2SiMe3. Similarly, at -20 Deg H2C:CMe2 gave 80% H2C:CMeCH2Li converted by CO2 or ethylene oxide into H2C:CMeCH2CO2H or H2C:CMe(CH2)3OH, resp. The similarly prepd. 2-C10H7CH2M (C10H7 = naphthyl; M = K, Li (I)] were obtained only with LiOCMe3 impurities due to their soly. I was characterized by carboxylation yielding 2-naphthaleneacetic acid. [on SciFinder (R)]
148 citations
TL;DR: The demonstration of the presence of CEA in non digestive carcinoma by classical gel precipitation analysis suggests that the CEA detected in the plasma of such patients by radioimmunoassay is also identical to colonic carcinoma CEA.
104 citations
TL;DR: In Gegenwart von Kalium-tert-butanolat vermag n-Butyllithium selbst so schwach acide Kohlenwasserstoffe wie (I) zu metallieren as discussed by the authors.
Abstract: In Gegenwart von Kalium-tert-butanolat vermag n-Butyllithium selbst so schwach acide Kohlenwasserstoffe wie (I) zu metallieren.
96 citations
TL;DR: The occurrence of IgD on a large percentage of the lymphocytes of human umbilical cord blood is reported.
Abstract: Immunoglobulin determinants have been demonstrated on the surface membrane of lymphocytes in man and other species1. Immunoglobulin on individual human lymphocytes is restricted to a single class, subclass and allotype2. Here we report the occurrence of IgD on a large percentage of the lymphocytes of human umbilical cord blood.
71 citations
TL;DR: The downward lateral transport of at least one inhibitor produced in or released by the cap of a maize root partly explains differences in growth of the upper and lower sides of roots placed in the horizontal position.
Abstract: The downward lateral transport of at least one inhibitor produced in or released by the cap of a maize root partly explains differences in growth of the upper and lower sides of roots placed in the horizontal position. The relative activity or level of such a regulator increases with the increase in root length.
58 citations
TL;DR: In this paper, the authors attempted to detect tumour-associated antigens in extracts from melanoma tumours and urine of patients and found that tumourdirected antibodies are found in the serum of patients suffering from malignant melanoma.
Abstract: TUMOUR-directed antibodies are found in the serum of patients suffering from malignant melanoma1–5, and so we have attempted to detect tumour-associated antigens in extracts from melanoma tumours and urine of patients.
42 citations
TL;DR: In this article, the reduction of the tetrachloroaurate (III) anion by L (L = PPh3, AsPh3 and SbPh3) is quantitative in non-aqueous solution.
Abstract: The reduction of the tetrachloroaurate (III) anion by L (L = PPh3, AsPh3, SbPh3) is quantitative in non-aqueous solution. The products are the gold(I)-complexes AuClL (L = AsPh3, SbPh3) and Au(PPh3)+2 together with the corresponding oxidation product LCl2. Kinetic studies show that the reactions are first order in AuCl−1 and L. In addition a path independent of PPh3 was found in dichloromethane. These data are interpreted in terms of mechanisms which involve reduction of AuCl−4 to AuCl−2 followed by equilibrium formation of AuClL for L = AsPh3 and SbPh3. For PPh3, the data are consistent with a chloride replacement by PPh3 to give AuCl3 PPh3, which is followed by a rapid reduction by a second mole of PPh3. Equilibrium formation constants are reported for several Au(I) complexes.
38 citations
TL;DR: In two-kidney Goldblatt hypertension, removal of the clamped kidney consistently caused a rapid return of the arterial pressure to normal, irrespective of the duration of hypertension, and unrelated to the excetory function of the contralateral kidney.
Abstract: The effect of either removing the clamped kidney or unclamping the renal artery on hypertension induced by partial constriction of one renal artery with (one-kidney Goldblatt hypertension) or without contralateral nephrectomy (two-kidney Goldblatt hypertension) was studied in rats, and the influence of unclamping on urinary water and electrolyte excretion was measured. In one-kidney Goldblatt hypertension, removal of the clamped kidney lowered blood pressure in the initial stage (first week), but had no significant effect on established hypertension. In contrast, unclamping rapidly and permanently normalized blood pressure in the chronic stage, and induced a transient, marked increase of urinary excretion of water, sodium and potassium. Ligating the ureter immediately before unclamping prevented the permanent (24 h) fall in arterial pressure, but did not abolish an initial (6 h) fall of blood pressure. In two-kidney Goldblatt hypertension, removal of the clamped kidney consistently caused a rapid return of the arterial pressure to normal, irrespective of the duration of hypertension, and unrelated to the excetory function of the contralateral kidney. Hypertensive rats of this type excreted significantly more sodium, potassium and water than control rats. Unclamping normalized blood pressure and did not significantly increase urinary sodium and water excretion, but sharply decreased potassium excretion.
33 citations
TL;DR: In this paper, the authors examined the equilibrium energy and kinetics of cis-trans isomerization of some bis(dialkylsulfide)dihaloplatinum(II) complexes by 1H-NMR.
Abstract: The equilibrium energetics and the kinetics of cis-trans isomerization of some bis(dialkylsulfide)dihaloplatinum(II) complexes have been examined by 1H-NMR. spectroscopy. The isomers are stable in chloroform but each form isomerizes to an equilibrium mixture when free dialkylsulfide is added. The cis to trans process is endothermic and the position of the equilibrium is markedly dependent on the nature of the donor atoms and of the solvent. The rate of isomerization of Pt(Me2S)2Cl2 is first order in complex and in Me2S. The isomerization proceeds by a double displacement mechanism as it is shown that the tris(dimethylsulfide)chloroplatinum(II) cation is an isolable intermediate of the reaction. When free Me2S is added to trans-Pd(Me2S)2Cl2, isomerization does not occur and one observes instead a fast ligand exchange. Its mechanism is the usual associative one for substitutions in square planar d8complexes.
24 citations
TL;DR: The uniformity of cell death ultrastructure in different organs and species was noticed, and the epigenetic factors like the biomechanic action of hemodynamics were considered, while the necrotic cells seem to be programmed to death by their genome.
Abstract: The ultrastructure of the “physiological” cell death was studied in distal ventral bulbar cushions of 15 chick embryo hearts on the 4th and 5th day of incubation. Microperfusion fixation was performed. The ultracytochemistry of a lysosomal hydrolytic enzyme acid phosphatase was also investigated in another 15 embryonic hearts.
21 citations
TL;DR: In this paper, the authors obtained kinetic data for the dehydrohalogenation in C6H6 and PhMe of vic-dihaloalkanes and vic-Dihalocycloalkanes in the presence of KOCMe3, which involved oligomeric alc aggregates which affected the stereochem. of the reaction.
Abstract: Kinetic data were obtained for the dehydrohalogenation in C6H6 and PhMe of vic-dihaloalkanes and vic-dihalocycloalkanes in the presence of KOCMe3. The mechanism involved oligomeric alc. aggregates which affected the stereochem. of the reaction. [on SciFinder (R)]
TL;DR: Aqueous nitrosation of primary α-carbonyl diazo compounds (e.g., Dioxacetate, Dioxioxacetone, dioxacetophenones) yields RCOCNO; their formation is demonstrated by 1,3-dipolar addition reactions as discussed by the authors.
Abstract: Aqueous nitrosation of primary α-carbonyl diazo compounds (ethyl diazoacetate, diazoacetone, diazoacetophenones) yields α-carbonyl nitrile oxides, RCOCNO; their formation is demonstrated by 1,3-dipolar addition reactions.
TL;DR: Slices of thickness 0.4 mm were capable of transporting glycine, β-methyl-glucoside and p-aminohippuric acid against considerable concentration gradients and had a lower oxygen consumption.
Abstract: A multiblade guillotine for the routine preparation of tissue slices is described. Its efficiency is illustrated with reference to biochemical, histochemical and histological properties of dog renal cortex slices of different thicknesses. Tissue destruction caused by the blades was minimal according to histological and histochemical examinations. Slices of thickness 0.4 mm were capable of transporting glycine, β-methyl-glucoside and p-aminohippuric acid against considerable concentration gradients. Thicker slices transported less efficiently and had a lower oxygen consumption.
TL;DR: In this article, the authors have untersucht die Glykokalyx der Zellen with the Alcianblau (AB)-, Rutheniumrot (RR)- and Lanthannitratmethode elektronenmikroskopisch untersuchs.
Abstract: Im Subcommissuralorgan der Ratte wurde die Glykokalyx der Zellen mit der Alcianblau (AB)-, Rutheniumrot (RR)- und Lanthannitratmethode elektronenmikroskopisch untersucht. Mit Alcianblau wird eine das apikale Plasmalemm, die Zilien und die Mikrovilli bedeckende, sehr elektronendichte Schicht dargestellt. Uber den Zilien und Mikrovilli wird eine zweite stark acianophile Hulle beschrieben, die anscheinend an der Bildung des alcianophilen Reissnerschen Fadens beteiligt ist. Starke Alcianophilie zeigt die cytoplasmatische Matrix der selten vorkommenden degenerierten Zellen bzw. der apikalen Zellteile. Mit Rutheniumrot werden auf dem apikalen Plasmalemm der Ependymzellen, den Mikrovilli, auf der Oberflache und im Innern des Reissnerschen Fadens RR-positive Schollen beobachtet. Die „periodisch strukturierten Korper“, Epithel- und Kapillarbasalmembranen zeigen kleine Rutheniumrot Niederschlage. Lanthannitrat-positives Material ist hauptsachlich zwischen den Hypendymzellen und basalen Ependymzellteilen lokalisiert. Die „periodisch strukturierten Korper“ reagieren intensiv mit Lanthannitrat. Epithel- und Kapillarbasalmembranen erscheinen unregelmasig gefarbt. Unsere Befunde sprechen dafur, das das AB-positive Material durch apikale Abstosung bzw. holokrine Auflosung der alcianohpilen Zellen entstehen kann. Der Ursprung des RR- und LN-positiven Materials ist unbekannt.
TL;DR: The inhibition transaminasique est partiellement levee lorsque les protoplastes ne sont plus en contact avec ces enzymes as mentioned in this paper, i.e., les enzymes degradant les parois cellulaires.
Abstract: Les enzymes employees pour l'obtention enzymatique des protoplastes de racines (Allium) alterent les transaminases (EC. 2.6.1.1.) de protoplastes mecaniquement prepares. Cette inhibition transaminasique est partiellement levee lorsque les protoplastes ne sont plus en contact avec ces enzymes. Les effets des enzymes degradant les parois cellulaires sont discutes relativement aux proprietes biochimiques des protoplastes.
TL;DR: In this paper, the root cap of Zea mays prevent geoperception, but georeactivity may be regained after several hours, and the time necessary to recover geosensitivity (GRT) is calculated using an intercept method.
TL;DR: In this article, a 3,6-substituted semibullvalenes were converted into 6acetoxy-tricyclo[3.3.0.02,8]octan-3-one in a three-step sequence.
Abstract: Acetolysis of diazoketone 1 gives in good yield 6-acetoxy-tricyclo[3.3.0.02,8]octan-3-one (2) which is converted into semibullvalene in a three-step sequence. Compound 2 is potentially a good starting material for 3,6-substituted semibullvalenes.
TL;DR: The benzilic acid rearrangement of ethyl α,β-dioxo-butyrate was studied by NMR-and UV-techniques in weak alkaline media (pH 11,5) as discussed by the authors.
Abstract: The benzilic acid rearrangement of ethyl α,β-dioxo-butyrate was studied by NMR.-and UV.-techniques. In weak alkaline media (pH 11,5) the intakt ester group migrates, with ester hydrolysis occuring as a second step.
TL;DR: In this article, the ultrastructure of the muscle spindles has been studied in human lumbrical muscles and compared with the morphology of rat and sheep examined with light and electron microscopy.
Abstract: The ultrastructure of the muscle spindles has been studied in human lumbrical muscles. The findings have been compared with the morphology of muscle spindles of rat and sheep examined with light and electron microscopy. The study is based on cross and longitudinal sections of the entire muscle spindle obtained by dissection. The different components of the spindle are described with special reference to the nuclear bag and nuclear chain fibres. These nuclei have been examined in human adult and newborn material and compared to the animal ones. ADN measurements revealed that although there are morphological differences between the two kinds of nuclei in human newborn spindles, the amount of ADN is the same as well in the nuclear bag as in the nuclear chain nuclei. Special attention is also given to the sensory and motor endings in the muscle spindles and to the presence of Pacinian corpuscules in these receptors. Finally two kinds of leptomeric organelles are described in human material.
TL;DR: It seems improbable that C cells play an important role in thermoregulation, as the mitotic indices of follicular as well as of C cells of rat thyroids showed a weakly marked circadian rhythm using the colchicine technique.
Abstract: Using the colchicine technique we found that the mitotic indices of follicular as well as of C cells of rat thyroids showed a weakly marked circadian rhythm with highest values at 19.30 and lowest values at 13.30.
TL;DR: In this article, a cyclisation of 1-bromo-5,5,10,10-tetraethoxycarbonyl-2,7-decadiyne (9b) using NaH in dilute solution gives 1,1,6,6-TETRAETHoxy carbonyl -cyclodeca-3,8-diyne in 17.6% yield.
Abstract: A cyclisation of 1-bromo-5,5,10,10-tetraethoxycarbonyl-2,7-decadiyne (9b) using NaH in dilute solution gives 1,1,6,6-tetraethoxycarbonyl-cyclodeca-3,8-diyne (8) in 17,6% yield. 9b is prepared by condensation of 1,1,6,6-tetraethoxycarbonyl-3-hexyne with 1,4-dibromo-2-butyne.
01 Jan 1973
TL;DR: For the stars of the spectral type included between A0 and G5, the effective temperature, the luminosity and the blanketing parameters were correlated with the absolute magnitude as mentioned in this paper.
Abstract: It is possible to obtain for the stars of the spectral type included between A0 and G5 three parameters respectively correlated with the effective temperature, the luminosity and the blanketing. A method to determine the absolute magnitude is given.
TL;DR: In this paper, Eymard et al. presented a framework for estimating the distance between two translators in a C-space of dimension 1 and a convex convex translation of the translators.
Abstract: On sait que la repr6sentation r6guliSre Q d'un groupe localement compact G contient faiblement la repr6sentation identit6 i G (dans un C-espace de dimension 1) si et seulement si pour tout f ~ C00(G) (ensemble des fonctions sur G complexes, continues et h support compact) la distance (pour la norme L 1) de 0 a l'enveloppe convexe des translat6s de f est [S~f(x) dx[ (off dx est une mesure de Haar invariante/t gauche). On s'int6resse dans ce travail ~ des rdsultats analogues concernant des repr6sentations zt unitaires continues arbitraires de G. Munissons Coo(G) de la semi-norme f~--~[lrc(f)][ off [[n(f)[[ est la norme de l'op6rateur z t ( f ) = S~ f (x)n(x)dx. Sans qu'il s'agisse, ~t proprement parler, d'une g6n6ralisation du r6sultat 6nonc6 ci-dessus, il r6sulte facilement de la proposition 15 ([1]) que z~ contient faiblement i~ si et seulement si la distance, pour la semi-norme f~-'* [In(f )H, de 0 ~ l'enveloppe convexe des translat6s de f est 6gale ~ ]~a f (x ) dx]. Nous montrons aussi (proposition 2) que r~ ne contient pas faiblement i G si et seulement si la distance pr6c6dente est nulle pour tout f~ Coo (G). Soit H u n sous-groupe ferm6 arbitraire de G. On donne une estimation de la distance, pour la semi-norme pr6c6dente, de 0 ~t l'ensemble des translat6s de f par H pour tout f ~ Coo (G) (corollaire de la proposition 4). On indique de plus, en termes de contenance faible, dans quelles circonstances cette distance est nulle pour tout f e Coo (G). Ceci nous conduit ~t tenter de caract6riser certaines propri6t6s des repr6sentations unitaires continues du sous-groupe ferm6 H par celles de Coo (G) muni de semi-normes 6troitement li6es aux repr6sentations induites sur G depuis H. L'auteur tient ~ remercier Monsieur Eymard pour ses utiles suggestions. Les principaux r6sultats de ce travail ont 6t6 annonc6s dans les Notices of the Amer. Math. Soc. 20 (1973) p. A-273.
TL;DR: In this paper, the authors compared Aoi's theories taking into account the anomalous contribution to that of Aslamazov-Larkin (AL) contribution only, or both the AL and an anomalous (Maki) contribution.
Abstract: The resistive transitions aboveH c on Al films with the thicknessd<ξ(0) have been measured as a function of the angle ϑ between the film surface and the magnetic field, where ξ(0) is the coherence length at 0 K. An observed broadness in the transitions is considered to be due to fluctuations aboveH c and is compared with Aoi's theories taking into account the Aslamazov—Larkin (AL) contribution only, or both the AL and an anomalous (Maki) contribution. At all angles the observed electrical conductivity due to fluctuations σ' is larger than the theoretical predictions based on the AL contribution alone. Except for angles near ϑ=0, the observed σ' can be explained by adding the anomalous contribution to that of AL.
TL;DR: In this paper, the authors measured the voltageV appearing along a type-II superconducting sample carrying a longitudinal currentI in the presence of a transverse magnetic fieldH. The analysis of the nonlinear part of V(I) curves does not verify the recent model of Sherrill and Payne.
Abstract: We have measured the voltageV appearing along a type-II superconducting sample carrying a longitudinal currentI in the presence of a transverse magnetic fieldH. The analysis of the nonlinear part ofV(I) curves does not verify the recent model of Sherrill and Payne. The linear part ofV(I) curves shows that the flux-flow resistivity ρf is exponential inH nearHc2, as Axt and Joiner found. We estimated the parameter α=(Hc2/ρn)(dρf/dH)H=Hc2 as a function of the reduced temperature and have compared it to some of the existing theories.
TL;DR: Urea and inulin clearances were measured in unanesthetized rats 5 and 50 h, and 2–3 weeks after unilateral nephrectomy, and a large increase of GFR was observed in rats chronically loaded and acutely infused with urea.
Abstract: Urea and inulin clearances were measured in unanesthetized rats 5 and 50 h, and 2–3 weeks after unilateral nephrectomy. At identical i-v infusion rates, urine flow in the uninephrectomized animals was similar to that of sham-operated controls. In the low range of urine flow rates, fractional urea excretion was higher in recently uninephrectomized animals than in controls. The increase appeared to be the consequence of the increased fractional excretion of water. At higher rates of urine flow, and after large loads of urea, the single kidney excreted urea in a manner similar to that of control kidneys. Urea clearances were, in 148/150 clearance determinations, lower than the simultaneously measured inulin clearances. A large increase of GFR was observed in rats chronically loaded and acutely infused with urea.
TL;DR: In this article, the temperature dependence of the amplitude of the rf size effect (RFSE) in Cd has been measured in order to determine the electronic mean free path (EMFP) for certain groups of charge carriers.
Abstract: Measurements of the temperature dependence of the amplitude of the rf size effect (RFSE) in Cd have been performed in order to determine the electronic mean free path (EMFP) for certain groups of charge carriers. Two kinds of effects were observed. One is identified as coming from the “lens” part of the Fermi surface. The temperature dependence of the EMFP is determined and compared to previous data. The other occurs at low fields. Although there is some question as to its origin, the EMFP vs. temperature is determined, based on the assumption that it is a size effect (rather than a single surface impedance effect), probably from the cigars of the Fermi surface. It is found that the RFSE is useful for finding the magnitude of the EMFP but that it may be difficult to determine the analytical form of its temperature dependence in comparison to proposed models.
TL;DR: The endothelial cells of iris capillaries in five female and male patients between 60 and 69 yr of age suffering from glaucoma simplex, presented a marked increase in specific endothelial organelles (SEO), suggesting a certain role in the regulation of intraocular pressure.
TL;DR: The absence of a hypotensive effect of furosemide in rats with one-kidney Goldblatt hypertension appeared to be due to enhanced renin secretion, which was significantly correlated with the amount of sodium and water lost.
Abstract: In rats made hypertensive by partial constriction of one renal artery and contralateral nephrectomy, large doses of furosemide had no hypotensive effect. However, when furosemide natriuresis was followed by removal of the clamped kidney, arterial blood pressure was greatly reduced. The fall of blood pressure induced in this manner was significantly correlated with the amount of sodium and water lost. The absence of a hypotensive effect of furosemide in rats with one-kidney Goldblatt hypertension appeared to be due to enhanced renin secretion. Furosemide not followed by nephrectomy caused a fall of blood pressure in rats with one-kidney Goldblatt hypertension after renin-depletion by desoxycorticosterone and salt treatment. Sodium wastage induced by peritoneal dialysis after removing the clamped kidney also lowered the blood pressure of hypertensive rats.
TL;DR: Data are consistent with the view that the stimulated renal gluconeogenesis in the NMMAA diabetic rat represents a significant proportion of total carbohydrate production in the body, and contributes to the elevation of the blood glucose level.
Abstract: The gluconeogenic capacity of the rat kidney cortex in the experimental diabetes induced by N-monomethylacetamide (NMMAA) was studied. Renal cortical slices from NMMAA diabetic rats synthesized glucose at an accelerated rate from pyruvate, α-ketoglutarate or fructose, but not from glutamine. In contrast, NMMAA added to the incubation medium inhibited glucose production by slices from normal rats, irrespective of the substrate used. To evaluate the role of renal gluconeogenesisin vivo, the effect of bilateral nephrectomy on the development of NMMAA-induced hyperglycemia was studied. The hyperglycemic effect of NMMAA was markedly blunted in nephrectomized rats. On the other hand, ureteral ligation after NMMAA administration did not prevent a normal rise in blood glucose. These data are consistent with the view that the stimulated renal gluconeogenesis in the NMMAA diabetic rat represents a significant proportion of total carbohydrate production in the body, and contributes to the elevation of the blood glucose level.