Institution
University of Lausanne
Education•Lausanne, Switzerland•
About: University of Lausanne is a education organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Medicine. The organization has 20508 authors who have published 46458 publications receiving 1996655 citations. The organization is also known as: Université de Lausanne & UNIL.
Topics: Population, Medicine, Context (language use), Gene, Immune system
Papers published on a yearly basis
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TL;DR: It is suggested that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways, which leads to the degradation via the proteasome pathway.
430 citations
TL;DR: Examination of secretory and endocytotic trafficking in Arabidopsis provides evidence that both endocytic and secretory cargo pass through the trans-Golgi network/early endosome (TGN/EE) and demonstrates that cargo in late endosomes/multivesicular bodies is destined for vacuolar degradation.
Abstract: Plants constantly adjust their repertoire of plasma membrane proteins that mediates transduction of environmental and developmental signals as well as transport of ions, nutrients, and hormones. The importance of regulated secretory and endocytic trafficking is becoming increasingly clear; however, our knowledge of the compartments and molecular machinery involved is still fragmentary. We used immunogold electron microscopy and confocal laser scanning microscopy to trace the route of cargo molecules, including the BRASSINOSTEROID INSENSITIVE1 receptor and the REQUIRES HIGH BORON1 boron exporter, throughout the plant endomembrane system. Our results provide evidence that both endocytic and secretory cargo pass through the trans-Golgi network/early endosome (TGN/EE) and demonstrate that cargo in late endosomes/multivesicular bodies is destined for vacuolar degradation. Moreover, using spinning disc microscopy, we show that TGN/EEs move independently and are only transiently associated with an individual Golgi stack.
430 citations
TL;DR: The growing number of available genome sequences from the green lineage offers first glimpses at the evolution of hormone pathways, which can aid in understanding the multiple relationships observed between these pathways in angiosperms.
429 citations
University of Milan1, University of Toronto2, University of Paris3, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico4, University of Belgrade5, University of Angers6, University of Lausanne7, Canberra Hospital8, Australian National University9, Uppsala University10, Queen's University Belfast11, Mayo Clinic12, King Saud bin Abdulaziz University for Health Sciences13, Sapienza University of Rome14, Catholic University of the Sacred Heart15, Harvard University16, Leipzig University17
TL;DR: NIV was used in 15% of patients with ARDS, irrespective of severity category, and NIV seems to be associated with higher ICU mortality in patients with a PaO2/FiO2 lower than 150 mm Hg.
Abstract: Rationale: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse.Objectives: To determine whether, during NIV, the categorization of ARDS severity based on the PaO2/FiO2 Berlin criteria is useful.Methods: The LUNG SAFE (Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) study described the management of patients with ARDS. This substudy examines the current practice of NIV use in ARDS, the utility of the PaO2/FiO2 ratio in classifying patients receiving NIV, and the impact of NIV on outcome.Measurements and Main Results: Of 2,813 patients with ARDS, 436 (15.5%) were managed with NIV on Days 1 and 2 following fulfillment of diagnostic criteria. Classification of ARDS severity based on PaO2/FiO2 ratio was associated with an increase in intensity of ventilatory support, NIV failure, and intensive care unit (ICU) mortality. NIV fa...
429 citations
Brigham and Women's Hospital1, University of Zurich2, Case Western Reserve University3, Yale University4, University of California, San Francisco5, University of California, Los Angeles6, University of Texas MD Anderson Cancer Center7, Mayo Clinic8, National Institutes of Health9, University of Lausanne10, Northwestern University11, NewYork–Presbyterian Hospital12, Johns Hopkins University School of Medicine13, Memorial Sloan Kettering Cancer Center14, University of Siena15, Heidelberg University16, Medical University of Vienna17, University of Paris18, University of Virginia19, University of Leeds20, Leiden University Medical Center21, Ludwig Maximilian University of Munich22, University Hospital Heidelberg23, Princess Margaret Cancer Centre24, Erasmus University Rotterdam25
TL;DR: Novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies and viral therapies will be reviewed, as well as the current challenges and future directions for research.
Abstract: Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.
429 citations
Authors
Showing all 20911 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Peer Bork | 206 | 697 | 245427 |
| Aaron R. Folsom | 181 | 1118 | 134044 |
| Kari Alitalo | 174 | 817 | 114231 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Johan Auwerx | 158 | 653 | 95779 |
| Silvia Franceschi | 155 | 1340 | 112504 |
| Matthias Egger | 152 | 901 | 184176 |
| Bart Staels | 152 | 824 | 86638 |
| Fernando Rivadeneira | 146 | 628 | 86582 |
| Christopher George Tully | 142 | 1843 | 111669 |
| Richard S. J. Frackowiak | 142 | 309 | 100726 |
| Peter Timothy Cox | 140 | 1267 | 95584 |
| Jürg Tschopp | 140 | 328 | 86900 |
| Stylianos E. Antonarakis | 138 | 746 | 93605 |
| Michael Weller | 134 | 1105 | 91874 |