University of Lausanne

About: University of Lausanne is a education organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Poison control. The organization has 20508 authors who have published 46458 publications receiving 1996655 citations. The organization is also known as: Université de Lausanne & UNIL.

The effectiveness of brief alcohol interventions in primary care settings: A systematic review

Abstract: Issues: Numerous studies have reported that brief interventions delivered in primary care are effective in reducing excessive drinking. However, much of this work has been criticised for being clinically unrepresentative. This review aimed to assess the effectiveness of brief interventions in primary care and determine if outcomes differ between efficacy and effectiveness trials. Approach: A pre-specified search strategy was used to search all relevant electronic databases up to 2006. We also hand-searched the reference lists of key articles and reviews. We included randomised controlled trials (RCT) involving patients in primary care who were not seeking alcohol treatment and who received brief intervention. Two authors independently abstracted data and assessed trial quality. Random effects meta-analyses, subgroup and sensitivity analyses and meta-regression were conducted. Key Findings: The primary meta-analysis included 22 RCT and evaluated outcomes in over 5800 patients. At 1 year follow up, patients receiving brief intervention had a significant reduction in alcohol consumption compared with controls [mean difference: -38 g week(-1), 95%CI (confidence interval): -54 to -23], although there was substantial heterogeneity between trials (I(2) = 57%). Subgroup analysis confirmed the benefit of brief intervention in men but not in women. Extended intervention was associated with a non-significantly increased reduction in alcohol consumption compared with brief intervention. There was no significant difference in effect sizes for efficacy and effectiveness trials. Conclusions: Brief interventions can reduce alcohol consumption in men, with benefit at a year after intervention, but they are unproven in women for whom there is insufficient research data. Longer counselling has little additional effect over brief intervention. The lack of differences in outcomes between efficacy and effectiveness trials suggests that the current literature is relevant to routine primary care. Language: en

The TRANSMED Transects in Space and Time: Constraints on the Paleotectonic Evolution of the Mediterranean Domain

Abstract: The Phanerozoic evolution of the western Tethyan region was dominated by terrane collisions and accretions, during the Variscan, Cimmerian and Alpine cycles. Most terranes were derived from Gondwana and present a similar early Palaeozoic evolution. Subsequently, they were detached from Gondwana and affected by different deformation and metamorphic events, which permit to decipher their geodynamic history. Lithospheric scale peri-Mediterranean transects show the present-day juxtaposition of these terranes, but do not allow to unravel their exotic nature or their duplication. To create a reliable palinspastic model around these transects, plate tectonics constraints must be taken into consideration in order to assess the magnitude of lateral displacements. For most of the transects and their different segments, thousand km scale differential transport can be demonstrated.

Does leadership need emotional intelligence

Abstract: Interest in emotional intelligence has bloomed over the last few years. That it has become a standard concept in general and applied psychology, as well as in applied business settings, is indubitable. Is this popularity warranted? Casting a shadow over the concept of emotional intelligence are concerns about its meaningfulness and the construct and predictive validity of its various measures. The following series of letters explores various issues surrounding emotional intelligence and leadership including: whether emotional intelligence is theoretically needed for leadership, the types of emotional intelligence tests that may hold the most promise, methodological standards for testing whether emotional intelligence matters, evidence from the neuroscience literature on emotions and intelligence, and evidence regarding the links between leader emotional intelligence and follower outcomes.

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

Abstract: Psoriasis is a common T-cell-mediated skin disease with 2-3% prevalence worldwide. Psoriasis is considered to be an autoimmune disease, but the precise nature of the autoantigens triggering T-cell activation remains poorly understood. Here we find that two-thirds of patients with moderate-to-severe plaque psoriasis harbour CD4(+) and/or CD8(+) T cells specific for LL37, an antimicrobial peptide (AMP) overexpressed in psoriatic skin and reported to trigger activation of innate immune cells. LL37-specific T cells produce IFN-γ, and CD4(+) T cells also produce Th17 cytokines. LL37-specific T cells can infiltrate lesional skin and may be tracked in patients blood by tetramers staining. Presence of circulating LL37-specific T cells correlates significantly with disease activity, suggesting a contribution to disease pathogenesis. Thus, we uncover a role of LL37 as a T-cell autoantigen in psoriasis and provide evidence for a role of AMPs in both innate and adaptive immune cell activation.