Institution
University of Lausanne
Education•Lausanne, Switzerland•
About: University of Lausanne is a education organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Poison control. The organization has 20508 authors who have published 46458 publications receiving 1996655 citations. The organization is also known as: Université de Lausanne & UNIL.
Topics: Population, Poison control, Immune system, Cytotoxic T cell, T cell
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TL;DR: The composite data suggest that via physical association with plasma lipoproteins, FIAF acts as a powerful signal from fat and other tissues to prevent fat storage and stimulate fat mobilization.
404 citations
TL;DR: It is shown that many NLRs interacted with the ubiquitin ligase–associated protein SGT1 and heat-shock protein 90, both of which have plant orthologs essential for R-protein responses.
Abstract: The family of mammalian Nod-like receptors (NLRs) consists of critical intracellular immune proteins structurally related to plant resistance proteins. The NLRs NALP3 and IPAF, for example, can each form a multiprotein proinflammatory complex called the 'inflammasome', and mutations in the gene encoding Nod2, another NLR, are positively associated with Crohn disease. Here we show that many NLRs interacted with the ubiquitin ligase–associated protein SGT1 and heat-shock protein 90 (HSP90), both of which have plant orthologs essential for R-protein responses. 'Knockdown' of SGT1 by small interfering RNA or chemical inhibition of HSP90 abrogated inflammasome activity, and inhibition of HSP90 blocked Nod2-mediated activation of the transcription factor NF-κB and reduced NALP3-mediated gout-like inflammation in mice. Our data demonstrate a similarity in one type of innate immunity in plants and mammals that is consistent with convergent evolution of a shared mechanism.
404 citations
TL;DR: Patients with NTG have a thinner CCT than do patients with POAG or controls, while overestimation of the IOP in normal subjects who have thick corneas may lead to a misdiagnosis of OHT.
Abstract: Objectives To determine the effect of central corneal thickness (CCT) on the measurement of intraocular pressure (IOP) and on the resultant reclassification of patients as having primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), or ocular hypertension (OHT). Methods Intraocular pressure (Goldmann applanation tonomety) and CCT (ultrasound pachymetry) were measured in 22 patients with NTG, 49 with POAG, 44 with OHT and in 18 control subjects. The CCT was used to obtain a corrected value for the IOP and to reclassify the type of glaucoma. Results There was no significant difference in CCT between controls (552±35 µm) and patients with POAG (543±35 µm), but the CCT in the group with NTG (521±31 µm) was significantly lower than that in the control group or the group with POAG ( P P Conclusions Patients with NTG have a thinner CCT than do patients with POAG or controls. Underestimation of the IOP in patients with POAG who have thin corneas may lead to a misdiagnosis of NTG, while overestimation of the IOP in normal subjects who have thick corneas may lead to a misdiagnosis of OHT.
404 citations
TL;DR: The regulation of C- ACS mRNA expression by fibrates and fatty acids is mediated by PPAR•retinoid X receptor heterodimers interacting through a PPRE in the C-ACS promoter, occupying a key position in the transcriptional control of a pivotal enzyme controlling the channeling of fatty acids into various metabolic pathways.
403 citations
GlaxoSmithKline1, University of Cambridge2, University of Ottawa3, University of Helsinki4, Erasmus University Rotterdam5, Imperial College London6, Wellcome Trust Sanger Institute7, University of London8, University of Leicester9, Queen Mary University of London10, National Institute for Health and Welfare11, University of Amsterdam12, National Institutes of Health13, National Research Council14, University of Michigan15, University of North Carolina at Chapel Hill16, University of Oulu17, University of Bristol18, University of Lausanne19, MedStar Washington Hospital Center20, University of Pennsylvania21, University of Texas Southwestern Medical Center22, University of Leeds23, The Heart Research Institute24, Massachusetts Institute of Technology25
TL;DR: In addition to those that are largely associated with LDL-C, genetic loci mainly associated with circulating triglycerides and HDL-C are also associated with risk of CAD, and these findings potentially provide new insights into the biological mechanisms underlying lipid metabolism and CAD risk.
Abstract: Objective—Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify n...
403 citations
Authors
Showing all 20911 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Peer Bork | 206 | 697 | 245427 |
| Aaron R. Folsom | 181 | 1118 | 134044 |
| Kari Alitalo | 174 | 817 | 114231 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Johan Auwerx | 158 | 653 | 95779 |
| Silvia Franceschi | 155 | 1340 | 112504 |
| Matthias Egger | 152 | 901 | 184176 |
| Bart Staels | 152 | 824 | 86638 |
| Fernando Rivadeneira | 146 | 628 | 86582 |
| Christopher George Tully | 142 | 1843 | 111669 |
| Richard S. J. Frackowiak | 142 | 309 | 100726 |
| Peter Timothy Cox | 140 | 1267 | 95584 |
| Jürg Tschopp | 140 | 328 | 86900 |
| Stylianos E. Antonarakis | 138 | 746 | 93605 |
| Michael Weller | 134 | 1105 | 91874 |