Institution
University of Lausanne
Education•Lausanne, Switzerland•
About: University of Lausanne is a education organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Poison control. The organization has 20508 authors who have published 46458 publications receiving 1996655 citations. The organization is also known as: Université de Lausanne & UNIL.
Topics: Population, Poison control, Immune system, Cytotoxic T cell, T cell
Papers published on a yearly basis
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TL;DR: It is demonstrated that neutrophils, typically viewed as cellular targets of IL-1β, themselves activate the NLRC4 inflammasome during acute Salmonella infection and are a major cell compartment for IL- 1β production during acute peritoneal challenge in vivo, which maximizes host proinflammatory and antimicrobial responses during pathogen challenge.
323 citations
TL;DR: In this article, the authors define the concepts of multilevel governance and accountability, and then identify the various dimensions of the latter, and argue that MLG generates novel forms of accountability, but undermines its democratic dimension mainly for the following reasons: the weak visibility of MLG networks, their selective composition and the prevalence of peer over public form of accountability.
Abstract: Most studies converge on the growth of processes of ‘multilevel governance’ (MLG) in policy making, related to the often combined trends towards supranationalism and regionalism. Such processes are usually analysed under the angle of their efficiency, while their impact on the quality of democracy is neglected. This article first defines the concepts of multilevel governance and accountability, and then identifies the various dimensions of the latter. It further argues that MLG generates novel forms of accountability, but undermines its democratic dimension mainly for the following reasons: the weak visibility of MLG networks, their selective composition and the prevalence of peer over public forms of accountability.
323 citations
TL;DR: The crystal structure of autoinhibited NLR family member NLRC4 is reported, which reveals the domains that are critical for interaction with adenosine diphosphate to keepNLRC4 in its inactive state and the domain that mediate oligomerization of the protein upon activation.
Abstract: Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins oligomerize into multiprotein complexes termed inflammasomes when activated. Their autoinhibition mechanism remains poorly defined. Here, we report the crystal structure of mouse NLRC4 in a closed form. The adenosine diphosphate-mediated interaction between the central nucleotide-binding domain (NBD) and the winged-helix domain (WHD) was critical for stabilizing the closed conformation of NLRC4. The helical domain HD2 repressively contacted a conserved and functionally important α-helix of the NBD. The C-terminal leucine-rich repeat (LRR) domain is positioned to sterically occlude one side of the NBD domain and consequently sequester NLRC4 in a monomeric state. Disruption of ADP-mediated NBD-WHD or NBD-HD2/NBD-LRR interactions resulted in constitutive activation of NLRC4. Together, our data reveal the NBD-organized cooperative autoinhibition mechanism of NLRC4 and provide insight into its activation.
323 citations
TL;DR: The metabolic balance method was performed on three men to investigate the fate of large excesses of carbohydrate and found that when the glycogen stores are saturated, massive intakes of carbohydrate are disposed of by high carbohydrate-oxidation rates and substantial de novo lipid synthesis without postabsorptive hyperglycemia.
323 citations
TL;DR: This work uses a model of cascade spreading to reveal architectural features of human brain networks that facilitate spreading and shows that the organizational principles of brain networks shape global communication and facilitate integrative function.
323 citations
Authors
Showing all 20911 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Peer Bork | 206 | 697 | 245427 |
| Aaron R. Folsom | 181 | 1118 | 134044 |
| Kari Alitalo | 174 | 817 | 114231 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Johan Auwerx | 158 | 653 | 95779 |
| Silvia Franceschi | 155 | 1340 | 112504 |
| Matthias Egger | 152 | 901 | 184176 |
| Bart Staels | 152 | 824 | 86638 |
| Fernando Rivadeneira | 146 | 628 | 86582 |
| Christopher George Tully | 142 | 1843 | 111669 |
| Richard S. J. Frackowiak | 142 | 309 | 100726 |
| Peter Timothy Cox | 140 | 1267 | 95584 |
| Jürg Tschopp | 140 | 328 | 86900 |
| Stylianos E. Antonarakis | 138 | 746 | 93605 |
| Michael Weller | 134 | 1105 | 91874 |