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Institution

University of Lausanne

EducationLausanne, Switzerland
About: University of Lausanne is a education organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Poison control. The organization has 20508 authors who have published 46458 publications receiving 1996655 citations. The organization is also known as: Université de Lausanne & UNIL.


Papers
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Journal ArticleDOI
15 May 1981-Science
TL;DR: In kittens, but not in adults, callosal axons also reach other regions, but there they appear to be confined to the lowest part of layer VI, where they apparently enter the gray matter only in the restricted regions where they will also be found in adults.
Abstract: The visual cortical areas in the two hemispheres are interconnected by axons running through the corpus callosum. In adult cats, these axons originate from, and terminate in, tangentially restricted portions of each area. In young kittens, however, callosal axons originate from the entire extent of each area, although they apparently enter the gray matter only in the restricted regions where they will also be found in adults. In kittens, but not in adults, callosal axons also reach other regions, but there they appear to be confined to the lowest part of layer VI. During the first two postnatal months, the callosal efferent zones become progressively restricted to their adult locations. During this process, many neurons eliminate the axons (or axon collaterals) that they had formerly sent through the corpus callosum and form permanent connection ipsilaterally.

573 citations

Journal ArticleDOI
22 Aug 2013-Nature
TL;DR: This work provides a genetic basis for investigating mechanisms of long-distance wound signalling in plants and indicates that plant genes related to those important for synaptic activity in animals function in organ-to-organ wound signalling.
Abstract: Wounded leaves communicate their damage status to one another through a poorly understood process of long-distance signalling. This stimulates the distal production of jasmonates, potent regulators of defence responses. Using non-invasive electrodes we mapped surface potential changes in Arabidopsis thaliana after wounding leaf eight and found that membrane depolarizations correlated with jasmonate signalling domains in undamaged leaves. Furthermore, current injection elicited jasmonoyl-isoleucine accumulation, resulting in a transcriptome enriched in RNAs encoding key jasmonate signalling regulators. From among 34 screened membrane protein mutant lines, mutations in several clade 3 GLUTAMATE RECEPTOR-LIKE genes (GLRs 3.2, 3.3 and 3.6) attenuated wound-induced surface potential changes. Jasmonate-response gene expression in leaves distal to wounds was reduced in a glr3.3 glr3.6 double mutant. This work provides a genetic basis for investigating mechanisms of long-distance wound signalling in plants and indicates that plant genes related to those important for synaptic activity in animals function in organ-to-organ wound signalling.

572 citations

Journal ArticleDOI
TL;DR: The data show that spine growth precedes synapse formation and that new synapses form preferentially onto existing boutons, and in some instances, two new spines contacted the same axon.
Abstract: Dendritic spines appear and disappear in an experience-dependent manner. Although some new spines have been shown to contain synapses, little is known about the relationship between spine addition and synapse formation, the relative time course of these events, or whether they are coupled to de novo growth of axonal boutons. We imaged dendrites in barrel cortex of adult mice over 1 month, tracking gains and losses of spines. Using serial section electron microscopy, we analyzed the ultrastructure of spines and associated boutons. Spines reconstructed shortly after they appeared often lacked synapses, whereas spines that persisted for 4 d or more always had synapses. New spines had a large surface-to-volume ratio and preferentially contacted boutons with other synapses. In some instances, two new spines contacted the same axon. Our data show that spine growth precedes synapse formation and that new synapses form preferentially onto existing boutons.

571 citations

Journal ArticleDOI
Jason Z. Liu1, Federica Tozzi2, Dawn M. Waterworth2, Sreekumar G. Pillai2, Pierandrea Muglia2, Lefkos T. Middleton3, Wade H. Berrettini4, Christopher W. Knouff2, Xin Yuan2, Gérard Waeber5, Peter Vollenweider5, Martin Preisig5, Nicholas J. Wareham6, Jing Hua Zhao6, Ruth J. F. Loos6, Ins Barroso7, Kay-Tee Khaw8, Scott M. Grundy, Philip J. Barter9, Robert W. Mahley10, Antero Kesäniemi11, Ruth McPherson12, John B. Vincent13, John Strauss13, James L. Kennedy13, Anne Farmer14, Peter McGuffin14, Richard O. Day15, Keith Matthews15, Per Bakke16, Amund Gulsvik16, Susanne Lucae17, Marcus Ising17, T. Brueckl17, S. Horstmann17, H.-Erich Wichmann18, Rajesh Rawal, Norbert Dahmen19, Claudia Lamina20, Ozren Polasek21, Lina Zgaga22, Jennifer E. Huffman22, Susan Campbell22, Jaspal S. Kooner3, John C. Chambers3, Mary Susan Burnett23, Joseph M. Devaney23, Augusto D. Pichard23, Kenneth M. Kent23, Lowell F. Satler23, Joseph M. Lindsay23, Ron Waksman23, Stephen E. Epstein23, James F. Wilson22, Sarah H. Wild22, Harry Campbell22, Veronique Vitart22, Muredach P. Reilly4, Mingyao Li4, Liming Qu4, Robert L. Wilensky4, William H. Matthai4, Hakon Hakonarson4, Daniel J. Rader4, Andre Franke24, Michael Wittig24, Arne Schäfer24, Manuela Uda25, Antonio Terracciano26, Xiangjun Xiao27, Fabio Busonero25, Paul Scheet27, David Schlessinger26, David St Clair28, Dan Rujescu18, Gonçalo R. Abecasis29, Hans J. Grabe30, Alexander Teumer30, Henry Völzke30, Astrid Petersmann30, Ulrich John30, Igor Rudan22, Igor Rudan31, Caroline Hayward22, Alan F. Wright22, Ivana Kolcic21, Benjamin J. Wright32, John R. Thompson32, Anthony J. Balmforth33, Alistair S. Hall33, Nilesh J. Samani32, Carl A. Anderson7, Tariq Ahmad, Christopher G. Mathew34, Miles Parkes, Jack Satsangi22, Mark J. Caulfield35, Patricia B. Munroe35, Martin Farrall1, Anna F. Dominiczak36, Jane Worthington, Wendy Thomson, Steve Eyre, Anne Barton, Vincent Mooser2, Clyde Francks1, Clyde Francks2, Jonathan Marchini1 
TL;DR: The Oxford-GlaxoSmithKline study (Ox-GSK) as discussed by the authors performed a genome-wide meta-analysis of SNP association with smoking-related behavioral traits and found an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19) that includes CHRNA5, CHRNA3 and CHRNB4.
Abstract: Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.

568 citations

Journal ArticleDOI

567 citations


Authors

Showing all 20911 results

NameH-indexPapersCitations
Peer Bork206697245427
Aaron R. Folsom1811118134044
Kari Alitalo174817114231
Ralph A. DeFronzo160759132993
Johan Auwerx15865395779
Silvia Franceschi1551340112504
Matthias Egger152901184176
Bart Staels15282486638
Fernando Rivadeneira14662886582
Christopher George Tully1421843111669
Richard S. J. Frackowiak142309100726
Peter Timothy Cox140126795584
Jürg Tschopp14032886900
Stylianos E. Antonarakis13874693605
Michael Weller134110591874
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023249
2022635
20213,969
20203,508
20193,091
20182,776