Showing papers by "University of Leicester published in 2006"

Integrating quantitative and qualitative research: how is it done?

Abstract: This article seeks to move beyond typologies of the ways in which quantitative and qualitative research are integrated to an examination of the ways that they are combined in practice. The article is based on a content analysis of 232 social science articles in which the two were combined. An examination of the research methods and research designs employed suggests that on the quantitative side structured interview and questionnaire research within a cross-sectional design tends to predominate, while on the qualitative side the semi-structured interview within a cross-sectional design tends to predominate. An examination of the rationales that are given for employing a mixed-methods research approach and the ways it is used in practice indicates that the two do not always correspond. The implications of this finding for how we think about mixed-methods research are outlined.

Anti-TNF Antibody Therapy in Rheumatoid Arthritis and the Risk of Serious Infections and Malignancies: Systematic Review and Meta-analysis of Rare Harmful Effects in Randomized Controlled Trials

Abstract: ContextTumor necrosis factor (TNF) plays an important role in host defense and tumor growth control. Therefore, anti-TNF antibody therapies may increase the risk of serious infections and malignancies.ObjectiveTo assess the extent to which anti-TNF antibody therapies may increase the risk of serious infections and malignancies in patients with rheumatoid arthritis by performing a meta-analysis to derive estimates of sparse harmful events occurring in randomized trials of anti-TNF therapy.Data SourcesA systematic literature search of EMBASE, MEDLINE, Cochrane Library, and electronic abstract databases of the annual scientific meetings of both the European League Against Rheumatism and the American College of Rheumatology was conducted through December 2005. This search was complemented with interviews of the manufacturers of the 2 licensed anti-TNF antibodies.Study SelectionWe included randomized, placebo-controlled trials of the 2 licensed anti-TNF antibodies (infliximab and adalimumab) used for 12 weeks or more in patients with rheumatoid arthritis. Nine trials met our inclusion criteria, including 3493 patients who received anti-TNF antibody treatment and 1512 patients who received placebo.Data ExtractionData on study characteristics to assess study quality and intention-to-treat data for serious infections and malignancies were abstracted. Published information from the trials was supplemented by direct contact between principal investigators and industry sponsors.Data SynthesisWe calculated a pooled odds ratio (Mantel-Haenszel methods with a continuity correction designed for sparse data) for malignancies and serious infections (infection that requires antimicrobial therapy and/or hospitalization) in anti-TNF–treated patients vs placebo patients. We estimated effects for high and low doses separately. The pooled odds ratio for malignancy was 3.3 (95% confidence interval [CI], 1.2-9.1) and for serious infection was 2.0 (95% CI, 1.3-3.1). Malignancies were significantly more common in patients treated with higher doses compared with patients who received lower doses of anti-TNF antibodies. For patients treated with anti-TNF antibodies in the included trials, the number needed to harm was 154 (95% CI, 91-500) for 1 additional malignancy within a treatment period of 6 to 12 months. For serious infections, the number needed to harm was 59 (95% CI, 39-125) within a treatment period of 3 to 12 months.ConclusionsThere is evidence of an increased risk of serious infections and a dose-dependent increased risk of malignancies in patients with rheumatoid arthritis treated with anti-TNF antibody therapy. The formal meta-analysis with pooled sparse adverse events data from randomized controlled trials serves as a tool to assess harmful drug effects.

Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study.

Abstract: Background— Different blood pressure (BP)–lowering drugs could have different effects on central aortic pressures and thus cardiovascular outcome despite similar effects on brachial BP. The Conduit Artery Function Evaluation (CAFE) study, a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), examined the impact of 2 different BP lowering-regimens (atenolol±thiazide-based versus amlodipine±perindopril-based therapy) on derived central aortic pressures and hemodynamics. Methods and Results— The CAFE study recruited 2199 patients in 5 ASCOT centers. Radial artery applanation tonometry and pulse wave analysis were used to derive central aortic pressures and hemodynamic indexes on repeated visits for up to 4 years. Most patients received combination therapy throughout the study. Despite similar brachial systolic BPs between treatment groups (Δ0.7 mm Hg; 95% CI, −0.4 to 1.7; P=0.2), there were substantial reductions in central aortic pressures with the amlodipine regimen (central aortic systolic ...

Comparison of Two Methods to Detect Publication Bias in Meta-analysis

Abstract: Results Type I error rates for Egger’s regression test are higher than those for the alternative regression test. The alternative regression test has the appropriate type I error rates regardless of the size of the underlying OR, the number of primary studies in the meta-analysis, and the level of between-study heterogeneity. The alternative regression test has comparable power to Egger’s regression test to detect publication bias under conditions of low between-study heterogeneity. Conclusion Because of appropriate type I error rates and reduction in the correlation between the lnOR and its variance, the alternative regression test can be used in place of Egger’s regression test when the summary estimates are lnORs.

Conducting a critical interpretive synthesis of the literature on access to healthcare by vulnerable groups

Abstract: Conventional systematic review techniques have limitations when the aim of a review is to construct a critical analysis of a complex body of literature This article offers a reflexive account of an attempt to conduct an interpretive review of the literature on access to healthcare by vulnerable groups in the UK This project involved the development and use of the method of Critical Interpretive Synthesis (CIS) This approach is sensitised to the processes of conventional systematic review methodology and draws on recent advances in methods for interpretive synthesis Many analyses of equity of access have rested on measures of utilisation of health services, but these are problematic both methodologically and conceptually A more useful means of understanding access is offered by the synthetic construct of candidacy Candidacy describes how people's eligibility for healthcare is determined between themselves and health services It is a continually negotiated property of individuals, subject to multiple influences arising both from people and their social contexts and from macro-level influences on allocation of resources and configuration of services Health services are continually constituting and seeking to define the appropriate objects of medical attention and intervention, while at the same time people are engaged in constituting and defining what they understand to be the appropriate objects of medical attention and intervention Access represents a dynamic interplay between these simultaneous, iterative and mutually reinforcing processes By attending to how vulnerabilities arise in relation to candidacy, the phenomenon of access can be better understood, and more appropriate recommendations made for policy, practice and future research By innovating with existing methods for interpretive synthesis, it was possible to produce not only new methods for conducting what we have termed critical interpretive synthesis, but also a new theoretical conceptualisation of access to healthcare This theoretical account of access is distinct from models already extant in the literature, and is the result of combining diverse constructs and evidence into a coherent whole Both the method and the model should be evaluated in other contexts

The WASP project and the superWASP cameras

Abstract: The SuperWASP cameras are wide‐field imaging systems at the Observatorio del Roque de los Muchachos on the island of La Palma in the Canary Islands, and at the Sutherland Station of the South African Astronomical Observatory. Each instrument has a field of view of some 482 deg2 with an angular scale of 13 \documentclass{aastex} \usepackage{amsbsy} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{bm} \usepackage{mathrsfs} \usepackage{pifont} \usepackage{stmaryrd} \usepackage{textcomp} \usepackage{portland,xspace} \usepackage{amsmath,amsxtra} \usepackage[OT2,OT1]{fontenc} ewcommand\cyr{ \renewcommand\rmdefault{wncyr} \renewcommand\sfdefault{wncyss} \renewcommand\encodingdefault{OT2} ormalfont \selectfont} \DeclareTextFontCommand{\textcyr}{\cyr} \pagestyle{empty} \DeclareMathSizes{10}{9}{7}{6} \begin{document} \landscape $\farcs$\end{document} 7 pixel−1, and is capable of delivering photometry with accuracy better than 1% for objects having \documentclass{aastex} \usepackage{amsbsy} \usepa...

The prevalence of co‐morbid depression in adults with Type 2 diabetes: a systematic review and meta‐analysis

Abstract: Aim To conduct a systematic literature review in order to estimate the prevalence and odds ratio of clinically relevant depression in adults with Type 2 diabetes compared with those without. Methods medline, embase and psycinfo databases were searched using MeSH terms and free text to identify relevant controlled studies. Published reference lists were also examined. Study selection and appraisal were conducted independently by two reviewers and a meta-analysis was performed to synthesize and analyse the data. Results Ten controlled studies including a total of 51 331 people were published between January 1980 and May 2005. The prevalence of depression was significantly higher in patients with Type 2 diabetes compared with those without [17.6 vs. 9.8%, OR = 1.6, 95%, confidence interval (CI) 1.2–2.0]. However, in most studies, patients with diabetes differed from those without on variables known to be associated with an increased risk of depression. The prevalence of depression was higher in females with diabetes (23.8%) compared with males (12.8%); however, the odds ratio for depression in patients with Type 2 diabetes compared with those without was higher in males (OR = 1.9, 95% CI 1.7–2.1) than females (OR = 1.3, 95% CI 1.2–1.4). Failure to report potential confounders prevented a more rigorous meta-analysis of risk. Conclusion We identified raised rates of depression in people with Type 2 diabetes, however, there is a need for well-controlled and better-reported studies to inform the development of effective treatments for depression in these patients.

Concordance of the Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) with standardized clinical assessments in the WHO World Mental Health surveys.

Abstract: The DSM-IV diagnoses generated by the fully structured lay-administered Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) in the WHO World Mental Health (WMH) surveys were compared to diagnoses based on follow-up interviews with the clinician-administered non-patient edition of the Structured Clinical Interview for DSM-IV (SCID) in probability subsamples of the WMH surveys in France, Italy, Spain, and the US. CIDI cases were oversampled. The clinical reappraisal samples were weighted to adjust for this oversampling. Separate samples were assessed for lifetime and 12-month prevalence. Moderate to good individual-level CIDI-SCID concordance was found for lifetime prevalence estimates of most disorders. The area under the ROC curve (AUC, a measure of classification accuracy that is not influenced by disorder prevalence) was 0.76 for the dichotomous classification of having any of the lifetime DSM-IV anxiety, mood and substance disorders assessed in the surveys and in the range 0.62-0.93 for individual disorders, with an inter-quartile range (IQR) of 0.71-0.86. Concordance increased when CIDI symptom-level data were added to predict SCID diagnoses in logistic regression equations. AUC for individual disorders in these equations was in the range 0.74-0.99, with an IQR of 0.87-0.96. CIDI lifetime prevalence estimates were generally conservative relative to SCID estimates. CIDI-SCID concordance for 12-month prevalence estimates could be studied powerfully only for two disorder classes, any anxiety disorder (AUC = 0.88) and any mood disorder (AUC = 0.83). As with lifetime prevalence, 12-month concordance improved when CIDI symptom-level data were added to predict SCID diagnoses. CIDI 12-month prevalence estimates were unbiased relative to SCID estimates. The validity of the CIDI is likely to be under-estimated in these comparisons due to the fact that the reliability of the SCID diagnoses, which is presumably less than perfect, sets a ceiling on maximum CIDI-SCID concordance.

Long γ-ray bursts and core-collapse supernovae have different environments

Abstract: When massive stars exhaust their fuel, they collapse and often produce the extraordinarily bright explosions known as core-collapse supernovae. On occasion, this stellar collapse also powers an even more brilliant relativistic explosion known as a long-duration γ-ray burst. One would then expect that these long γ-ray bursts and core-collapse supernovae should be found in similar galactic environments. Here we show that this expectation is wrong. We find that the γ-ray bursts are far more concentrated in the very brightest regions of their host galaxies than are the core-collapse supernovae. Furthermore, the host galaxies of the long γ-ray bursts are significantly fainter and more irregular than the hosts of the core-collapse supernovae. Together these results suggest that long-duration γ-ray bursts are associated with the most extremely massive stars and may be restricted to galaxies of limited chemical evolution. Our results directly imply that long γ-ray bursts are relatively rare in galaxies such as our own Milky Way.

The association of GRB 060218 with a supernova and the evolution of the shock wave

Abstract: A link between long γ-ray bursts (GRBs) and supernovae has been established, but whether there is a similar relationship between the weaker and softer X-ray flashes and supernovae is unclear. GRB/XRF 060218, spotted by the Swift satellite on 18 February this year, may supply that missing link. In the first of four papers on this novel burster, Campana et al. report the sighting of the X-ray signature of a shock break-out, possible evidence of a supernova in progress. Pian et al. report the optical discovery of a type Ic supernova 2006aj associated with GRB/XRF 060218. Soderberg et al. report radio and X-ray observations that show that XRF 060218 is 100 times less energetic than, but of a type that is ten times more common than cosmological GRBs. Mazzali et al. modelled the spectra and light curve of SN 2006aj to show that it had a much smaller explosion energy and ejected much less mass than other GRB-supernovae, suggesting that it was produced by a star with a mass was only about 20 times that of the Sun, leaving behind a neutron star, rather than a black hole. Observations of the close gamma-ray burst GRB 060218 and its connection to supernova SN 2006aj reveal the break-out of a shock wave driven by a mildly relativistic shell into the dense wind surrounding the GRB progenitor. These observation catch a supernova in the act of exploding. Although the link between long γ-ray bursts (GRBs) and supernovae has been established1,2,3,4, hitherto there have been no observations of the beginning of a supernova explosion and its intimate link to a GRB. In particular, we do not know how the jet that defines a γ-ray burst emerges from the star's surface, nor how a GRB progenitor explodes. Here we report observations of the relatively nearby GRB 060218 (ref. 5) and its connection to supernova SN 2006aj (ref. 6). In addition to the classical non-thermal emission, GRB 060218 shows a thermal component in its X-ray spectrum, which cools and shifts into the optical/ultraviolet band as time passes. We interpret these features as arising from the break-out of a shock wave driven by a mildly relativistic shell into the dense wind surrounding the progenitor7. We have caught a supernova in the act of exploding, directly observing the shock break-out, which indicates that the GRB progenitor was a Wolf–Rayet star.

How can systematic reviews incorporate qualitative research? A critical perspective:

Abstract: Systematic review has developed as a specific methodology for searching for, appraising and synthesizing findings of primary studies, and has rapidly become a cornerstone of the evidence-based practice and policy movement. Qualitative research has traditionally been excluded from systematic reviews, and much effort is now being invested in resolving the daunting methodological and epistemological challenges associated with trying to move towards more inclusive forms of review. We describe our experiences, as a very diverse multidisciplinary group, in attempting to incorporate qualitative research in a systematic review of support for breastfeeding. We show how every stage of the review process, from asking the review question through to searching for and sampling the evidence, appraising the evidence and producing a synthesis, provoked profound questions about whether a review that includes qualitative research can remain consistent with the frame offered by current systematic review methodology. We conclude that more debate and dialogue between the different communities that wish to develop review methodology is needed, and that attempts to impose dominant views about the appropriate means of conducting reviews of qualitative research should be resisted so that innovation can be fostered. Copyright © 2006 SAGE Publications.

Resolved Massive Star Clusters in the Milky Way and its Satellites: Brightness Profiles and a Catalogue of Fundamental Parameters

Abstract: [Abridged]: We present a database of structural and dynamical properties for 153 spatially resolved star clusters (50 "young massive clusters" and 103 old globulars) in the Milky Way, the Large and Small Magellanic Clouds, and the Fornax dwarf spheroidal. This database complements and extends others in the literature, such as those of Harris, and Mackey & Gilmore. By fitting a number of models to the clusters' density profiles, we derive various characteristic surface brightnesses and radii; central potentials, velocity dispersions, and escape velocities; total luminosities, masses, and binding energies; phase-space densities and relaxation timescales; and ``kappa-space'' parameters. Population-synthesis models are used to predict intrinsic (B-V) colors, reddenings, and V-band mass-to-light ratios for the same 153 clusters plus another 63 globulars in the Milky Way, and we compare these predictions to the observed quantities where available. These results are intended to serve as the basis for future investigations of structural correlations and the fundamental plane of massive star clusters, including especially comparisons between the systemic properties of young and old clusters. We also address the question of what structural model fits each cluster best, and argue that the extended halos known to characterize many Magellanic Cloud clusters may be examples of the generic envelope structure of self-gravitating star clusters, not just transient features associated strictly with young age.

Evidence for a Canonical Gamma-Ray Burst Afterglow Light Curve in the Swift XRT Data

Abstract: We present new observations of the early X-ray afterglows of the first 27 gamma-ray bursts (GRBs) well observed by the Swift X-Ray Telescope (XRT). The early X-ray afterglows show a canonical behavior, where the light curve broadly consists of three distinct power-law segments: (1) an initial very steep decay (/t � � with 3P � 1 P5), followed by (2) a very shallow decay (0:5P � 2 P1:0), and finally (3) a somewhat steeper decay (1P � 3 P1:5). These power-law segments are separated by two corresponding break times, tbreak;1 P500 s and 10 3 sPtbreak;2P 10 4 s. On top of this canonical behavior, many events have superimposed X-ray flares, which are most likely caused by internal shocks due to long-lasting sporadic activity of the central engine, up to several hours after the GRB. We find that the initial steep decay is consistent with it being the tail of the prompt emission, from photons that are radiated at large angles relative to our line of sight. The first break in the light curve (tbreak;1) takes place when the forward shock emission becomes dominant, with the intermediate shallow flux decay (� 2) likely caused by the continuous energy injection into the external shock. When this energy injection stops, a second break is then observed in the light curve (tbreak;2). This energy injection increases the energy of the afterglow shock by at least a factor of f k4 and augments the already severe requirements for the efficiency of the prompt gamma-ray emission. Subject headingg gamma rays: bursts — radiation mechanisms: nonthermal

Application of ionic liquids to the electrodeposition of metals

Abstract: The electrodeposition of most of technologically important metals has been shown to be possible from a wide range of room temperature molten salts, more commonly known today as 'ionic liquids'. These liquids are currently under intense scrutiny for a wide variety of applications some of which have already been commercialized. Despite the fact that electrodeposition was the first application studied in these liquids no metal deposition processes have as yet been developed to an industrial scale. This review addresses the practical and theoretical aspects that need to be considered when choosing ionic liquids for metal deposition. It details the current understanding of the physical and chemical properties of these interesting fluids and highlights the areas that need to be considered to develop practical electroplating systems. The effect of composition and temperature on viscosity and conductivity are discussed together with the fundamental approaches required to synthesise new liquids.

Improved on-line broadcast scheduling with deadlines

Abstract: We study an on-line broadcast scheduling problem in which requests have deadlines, and the objective is to maximize the weighted throughput, i.e., the weighted total length of the satisfied requests. For the case where all requested pages have the same length, we present an online deterministic algorithm named BAR and prove that it is 4.56-competitive. This improves the previous algorithm of Kim and Chwa [11] which is shown to be 5-competitive by Chan et al. [4]. In the case that pages may have different lengths, we prove a lower bound of Ω(Δ/logΔ) on the competitive ratio where Δ is the ratio of maximum to minimum page lengths. This improves upon the previous $\sqrt{\Delta}$ lower bound in [11,4] and is much closer to the current upper bound of ($\Delta+2\sqrt{\Delta}+2$) in [7]. Furthermore, for small values of Δ we give better lower bounds.

Positive psychology: Past, present, and (possible) future

Abstract: What is positive psychology? Where has it come from? Where is it going? These are the questions we address in this article. In defining positive psychology, we distinguish between the meta-psychological level, where the aim of positive psychology is to redress the imbalance in psychology research and practice, and the pragmatic level, which is concerned with what positive psychologists do, in terms of their research, practice, and areas of interest. These distinctions in how we understand positive psychology are then used to shape conceptions of possible futures for positive psychology. In conclusion, we identify several pertinent issues for the consideration of positive psychology as it moves forward. These include the need to synthesize the positive and negative, build on its historical antecedents, integrate across levels of analysis, build constituency with powerful stakeholders, and be aware of the implications of description versus prescription.

Publication Bias in Meta-Analysis

Abstract: Publication bias is the term for what occurs whenever the research that appears in the published literature is systematically unrepresentative of the population of completed studies. Simply put, when the research that is readily available differs in its results from the results of all the research that has been done in an area, readers and reviewers of that research are in danger of drawing the wrong conclusion about what that body of research shows. In some cases this can have dramatic consequences, as when an ineffective or dangerous treatment is falsely viewed as safe and effective. This can be illustrated by two events that received much media attention as this book was going to press in late 2004. These are the debate surrounding Merck’s recall of Vioxx, a popular arthritis drug (Merck maintained that it recalled Vioxx as soon as the data indicated the high prevalence of cardiovascular events among those who took Vioxx for more than 18 months, while media reports said that Merck hid adverse event evidence for years), and the use of selective serotonin reuptake inhibitor (SSRI) anti-depressants among adolescents (Elliott Spitzer, attorney general of New York State, filed a 2004 lawsuit against GlaxoSmithKline,

On maximizing the second smallest eigenvalue of a state-dependent graph Laplacian

Abstract: We consider the set G consisting of graphs of fixed order and weighted edges. The vertex set of graphs in G will correspond to point masses and the weight for an edge between two vertices is a functional of the distance between them. We pose the problem of finding the best vertex positional configuration in the presence of an additional proximity constraint, in the sense that, the second smallest eigenvalue of the corresponding graph Laplacian is maximized. In many recent applications of algebraic graph theory in systems and control, the second smallest eigenvalue of Laplacian has emerged as a critical parameter that influences the stability and robustness properties of dynamic systems that operate over an information network. Our motivation in the present work is to "assign" this Laplacian eigenvalue when relative positions of various elements dictate the interconnection of the underlying weighted graph. In this venue, one would then be able to "synthesize" information graphs that have desirable system theoretic properties.

The role of the mast cell in the pathophysiology of asthma.

Abstract: There is compelling evidence that human mast cells contribute to the pathophysiology of asthma. Mast cells, but not T cells or eosinophils, localize within the bronchial smooth muscle bundles in patients with asthma but not in normal subjects or those with eosinophilic bronchitis, a factor likely to be important in determining the asthmatic phenotype. The mechanism of mast cell recruitment by asthmatic airway smooth muscle involves the CXCL10/CXCR3 axis, and several mast cell mediators have profound effects on airway smooth muscle function. The autacoids are established as potent bronchoconstrictors, whereas the proteases tryptase and chymase are being demonstrated to have a range of actions consistent with key roles in inflammation, tissue remodeling, and bronchial hyperresponsiveness. IL-4 and IL-13, known mast cell products, also induce bronchial hyperresponsiveness in the mouse independent of the inflammatory response and enhance the magnitude of agonist-induced intracellular Ca2+ responses in cultured human airway smooth muscle. There are therefore many pathways by which the close approximation of mast cells with airway smooth muscle cells might lead to disordered airway smooth muscle function. Mast cells also infiltrate the airway mucous glands in subjects with asthma, showing features of degranulation, and a positive correlation with the degree of mucus obstructing the airway lumen, suggesting that mast cells play an important role in regulating mucous gland secretion. The development of potent and specific inhibitors of mast cell secretion, which remain active when administered long-term to asthmatic airways, should offer a novel approach to the treatment of asthma.

An optical supernova associated with the X-ray flash XRF 060218.

Abstract: Long-duration gamma-ray bursts (GRBs) are associated with type Ic supernovae(1) that are more luminous than average(2-5) and that eject material at very high velocities. Less-luminous supernovae were not hitherto known to be associated with GRBs, and therefore GRB - supernovae were thought to be rare events(6). Whether X-ray flashes - analogues of GRBs, but with lower luminosities and fewer gamma-rays - can also be associated with supernovae, and whether they are intrinsically 'weak' events or typical GRBs viewed off the axis of the burst(7), is unclear. Here we report the optical discovery and follow-up observations of the type Ic supernova SN 2006aj associated with X-ray flash XRF 060218. Supernova 2006aj is intrinsically less luminous than the GRB - supernovae, but more luminous than many supernovae not accompanied by a GRB. The ejecta velocities derived from our spectra are intermediate between these two groups, which is consistent with the weakness of both the GRB output(8) and the supernova radio flux(9). Our data, combined with radio and X-ray observations(8-10), suggest that XRF 060218 is an intrinsically weak and soft event, rather than a classical GRB observed off-axis. This extends the GRB - supernova connection to X-ray flashes and fainter supernovae, implying a common origin. Events such as XRF 060218 are probably more numerous than GRB - supernovae.

Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn's disease.

Abstract: Summary Background Crohn's disease is associated with small bowel cancer whilst risk of colorectal cancer is less clear Aim To ascertain the combined estimates of relative risk of these cancers in Crohn's disease Methods MEDLINE was searched to identify relevant papers Exploding references identified additional publications When two papers reviewed the same cohort, the later study was used Results Meta-analysis showed overall colorectal cancer relative risk in Crohn's disease as 25 (13–47), 45 (13–149) for patients with colonic disease and 11 (08–15) in ileal disease Meta-regression showed reduction in relative risk over the past 30 years Subgroup analysis showed Scandinavia had significantly lower colorectal cancer relative risk than the UK and North America Cumulative risk analysis showed 10 years following diagnosis of Crohn's disease relative risk of colorectal cancer is 29% (15%–53%) Meta-analysis showed small bowel cancer relative risk in Crohn's disease is 332 (159–609) Small bowel cancer relative risk has not significantly reduced over the last 30 years Conclusion Relative risk of colorectal and small bowel cancers are significantly raised in Crohn's disease Cumulative risk of colorectal cancer of 29% at 10 years suggests a potential benefit from routine screening However, the value of screening requires rigorous appraisal

Solubility of Metal Oxides in Deep Eutectic Solvents Based on Choline Chloride

Abstract: The solubility of 17 commonly available metal oxides in the elemental mass series Ti through Zn have been determined in three ionic liquids based on choline chloride. The hydrogen bond donors used were urea, malonic acid, and ethylene glycol. The results obtained are compared with aqueous solutions of HCl and NaCl. Some correlation is observed between the solubility in the deep eutectic solvents and that in aqueous solutions but some significant exceptions offer an opportunity for novel solvato-metallurgical processes.

A new γ-ray burst classification scheme from GRB 060614

Abstract: Gamma-ray bursts (GRBs) are known to come in two duration classes, separated at ~2 s. Long-duration bursts originate from star-forming regions in galaxies, have accompanying supernovae when these are near enough to observe and are probably caused by massive-star collapsars. Recent observations show that short-duration bursts originate in regions within their host galaxies that have lower star-formation rates, consistent with binary neutron star or neutron star–black hole mergers. Moreover, although their hosts are predominantly nearby galaxies, no supernovae have been so far associated with short-duration GRBs. Here we report that the bright, nearby GRB 060614 does not fit into either class. Its ~102-s duration groups it with long-duration GRBs, while its temporal lag and peak luminosity fall entirely within the short-duration GRB subclass. Moreover, very deep optical observations exclude an accompanying supernova, similar to short-duration GRBs. This combination of a long-duration event without an accompanying supernova poses a challenge to both the collapsar and the merging-neutron-star interpretations and opens the door to a new GRB classification scheme that straddles both long- and short-duration bursts.

SUN1 interacts with nuclear lamin a and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton

Abstract: Nuclear migration and positioning within cells are critical for many developmental processes and are governed by the cytoskeletal network. Although mechanisms of nuclear-cytoskeletal attachment are unclear, growing evidence links a novel family of nuclear envelope (NE) proteins that share a conserved C-terminal SUN (Sad1/UNC-84 homology) domain. Analysis of Caenorhabditis elegans mutants has implicated UNC-84 in actin-mediated nuclear positioning by regulating NE anchoring of a giant actin-binding protein, ANC-1. Here, we report the identification of SUN1 as a lamin A-binding protein in a yeast two-hybrid screen. We demonstrate that SUN1 is an integral membrane protein located at the inner nuclear membrane. While the N-terminal domain of SUN1 is responsible for detergent-resistant association with the nuclear lamina and lamin A binding, lamin A/C expression is not required for SUN1 NE localization. Furthermore, SUN1 does not interact with type B lamins, suggesting that NE localization is ensured by binding to an additional nuclear component(s), most likely chromatin. Importantly, we find that the luminal C-terminal domain of SUN1 interacts with the mammalian ANC-1 homologs nesprins 1 and 2 via their conserved KASH domain. Our data provide evidence of a physical nuclear-cytoskeletal connection that is likely to be a key mechanism in nuclear-cytoplasmic communication and regulation of nuclear position.

Causes and consequences of error in digital elevation models

Abstract: All digital data contain error and many are uncertain. Digital models of elevation surfaces consist of files containing large numbers of measurements representing the height of the surface of the earth, and therefore a proportion of those measurements are very likely to be subject to some level of error and uncertainty. The collection and handling of such data and their associated uncertainties has been a subject of considerable research, which has focused largely upon the description of the effects of interpolation and resolution uncertainties, as well as modelling the occurrence of errors. However, digital models of elevation derived from new technologies employing active methods of laser and radar ranging are becoming more widespread, and past research will need to be re-evaluated in the near future to accommodate such new data products. In this paper we review the source and nature of errors in digital models of elevation, and in the derivatives of such models. We examine the correction of errors and assessment of fitness for use, and finally we identify some priorities for future research.