Institution
University of Lincoln
Education•Lincoln, Lincolnshire, United Kingdom•
About: University of Lincoln is a education organization based out in Lincoln, Lincolnshire, United Kingdom. It is known for research contribution in the topics: Population & Higher education. The organization has 2341 authors who have published 7025 publications receiving 124797 citations.
Topics: Population, Higher education, Mental health, Health care, Robot
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this article, the authors argue that political astuteness provides an important conceptual linkage between leadership and public value, enabling actors to read, understand and foster coalitions around diverse and sometimes competing interests.
Abstract: Both leadership and public value are increasingly seen as concepts highly relevant to public administration, not only because of complex societal challenges but also as ways to address pluralistic interests in society. This article explores in detail the varied conceptualizations of public value and of public leadership. Furthermore, we argue that political astuteness provides an important conceptual linkage between leadership and public value, enabling actors to read, understand and foster coalitions around diverse and sometimes competing interests. In this introduction to the symposium, we analyse the different conceptualizations of public value, of leadership, and also show how the six articles explicitly or implicitly draw on the linking concept of political astuteness. The article assesses how the six articles of the symposium contribute to each of these three concepts.
42 citations
•
TL;DR: A new capsule routing algorithm derived from Variational Bayes for fitting a mixture of transforming gaussians, and it is shown it is possible transform the authors' capsule network into a Capsule-VAE.
Abstract: Capsule networks are a recently proposed type of neural network shown to outperform alternatives in challenging shape recognition tasks. In capsule networks, scalar neurons are replaced with capsule vectors or matrices, whose entries represent different properties of objects. The relationships between objects and their parts are learned via trainable viewpoint-invariant transformation matrices, and the presence of a given object is decided by the level of agreement among votes from its parts. This interaction occurs between capsule layers and is a process called routing-by-agreement. In this paper, we propose a new capsule routing algorithm derived from Variational Bayes for fitting a mixture of transforming gaussians, and show it is possible transform our capsule network into a Capsule-VAE. Our Bayesian approach addresses some of the inherent weaknesses of MLE based models such as the variance-collapse by modelling uncertainty over capsule pose parameters. We outperform the state-of-the-art on smallNORB using 50% fewer capsules than previously reported, achieve competitive performances on CIFAR-10, Fashion-MNIST, SVHN, and demonstrate significant improvement in MNIST to affNIST generalisation over previous works.
42 citations
••
Wageningen University and Research Centre1, American Museum of Natural History2, University of Ljubljana3, Aarhus University4, University of Oulu5, University of Lausanne6, University of Porto7, University of Johannesburg8, Swedish University of Agricultural Sciences9, University of Warsaw10, University of Lincoln11, Aalborg University12, Polish Academy of Sciences13, Centre national de la recherche scientifique14, University of Grenoble15, Spanish National Research Council16
TL;DR: Enhanced cooperation among genetic researchers dealing with large carnivores in consortia would facilitate streamlining of methods, their faster and wider adoption, and production of results at the large spatial scales that ultimately matter for the conservation of these charismatic species.
Abstract: Following protection measures implemented since the 1970s, large carnivores are currently increasing in number and returning to areas from which they were absent for decades or even centuries. Monitoring programmes for these species rely extensively on non-invasive sampling and genotyping. However, attempts to connect results of such studies at larger spatial or temporal scales often suffer from the incompatibility of genetic markers implemented by researchers in different laboratories. This is particularly critical for long-distance dispersers, revealing the need for harmonized monitoring schemes that would enable the understanding of gene flow and dispersal dynamics.
Based on a review of genetic studies on grey wolves Canis lupus from Europe, we provide an overview of the genetic markers currently in use, and identify opportunities and hurdles for studies based on continent-scale datasets.
Our results highlight an urgent need for harmonization of methods to enable transnational research based on data that have already been collected, and to allow these data to be linked to material collected in the future. We suggest timely standardization of newly developed genotyping approaches, and propose that action is directed towards the establishment of shared single nucleotide polymorphism panels, next-generation sequencing of microsatellites, a common reference sample collection and an online database for data exchange.
Enhanced cooperation among genetic researchers dealing with large carnivores in consortia would facilitate streamlining of methods, their faster and wider adoption, and production of results at the large spatial scales that ultimately matter for the conservation of these charismatic species.
42 citations
••
TL;DR: This issue may be freely reproduced for the purposes of private research and study and extracts may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising.
Abstract: © Queen’s Printer and Controller of HMSO 2018. This work was produced by O’Cathain et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
42 citations
••
TL;DR: The presence of the SCN1A IVS5-91G>A SNP is associated with susceptibility to epilepsy and SNPs in EPHX1 gene are influencing CBZ metabolism and disposition, which is not an indicator of resistance to the therapy.
Abstract: Aim
The present study aimed to evaluate the effects of gene variants in key genes influencing pharmacokinetic and pharmacodynamic of carbamazepine (CBZ) on the response in patients with epilepsy.
Materials & Methods
Five SNPs in two candidate genes influencing CBZ transport and metabolism, namely ABCB1 or EPHX1, and CBZ response SCN1A (sodium channel) were genotyped in 145 epileptic patients treated with CBZ as monotherapy and 100 age and sex matched healthy controls. Plasma concentrations of CBZ, carbamazepine-10,11-epoxide (CBZE) and carbamazepine-10,11-trans dihydrodiol (CBZD) were determined by HPLC-UV-DAD and adjusted for CBZ dosage/kg of body weight.
Results
The presence of the SCN1A IVS5-91G>A variant allele is associated with increased epilepsy susceptibility. Furthermore, carriers of the SCN1A IVS5-91G>A variant or of EPHX1 c.337T>C variant presented significantly lower levels of plasma CBZ compared to carriers of the common alleles (0.71±0.28 vs 1.11±0.69 μg/mL per mg/Kg for SCN1A IVS5-91 AA vs GG and 0.76±0.16 vs 0.94±0.49 μg/mL per mg/Kg for EPHX1 c.337 CC vs TT; P G showed a reduced microsomal epoxide hydrolase activity as reflected by a significantly decreased ratio of CBZD to CBZ (0.13±0.08 to 0.26±0.17, p T SNP and SCN1A 3148A>G variants were not associated with significant changes in CBZ pharmacokinetic. Patients resistant to CBZ treatment showed increased dosage of CBZ (657±285 vs 489±231 mg/day; P<0.001) but also increased plasma levels of CBZ (9.84±4.37 vs 7.41±3.43 μg/mL; P<0.001) compared to patients responsive to CBZ treatment. CBZ resistance was not related to any of the SNPs investigated.
Conclusions
The SCN1A IVS5-91G>A SNP is associated with susceptibility to epilepsy. SNPs in EPHX1 gene are influencing CBZ metabolism and disposition. CBZ plasma levels are not an indicator of resistance to the therapy.
42 citations
Authors
Showing all 2452 results
Name | H-index | Papers | Citations |
---|---|---|---|
David R. Williams | 178 | 2034 | 138789 |
David Scott | 124 | 1561 | 82554 |
Hugh S. Markus | 118 | 606 | 55614 |
Timothy E. Hewett | 116 | 531 | 49310 |
Wei Zhang | 96 | 1404 | 43392 |
Matthew Hall | 75 | 827 | 24352 |
Matthew C. Walker | 73 | 443 | 16373 |
James F. Meschia | 71 | 401 | 28037 |
Mark G. Macklin | 69 | 268 | 13066 |
John N. Lester | 66 | 349 | 19014 |
Christine J Nicol | 61 | 268 | 10689 |
Lei Shu | 59 | 598 | 13601 |
Frank Tanser | 54 | 231 | 17555 |
Simon Parsons | 54 | 462 | 15069 |
Christopher D. Anderson | 54 | 393 | 10523 |