University of Lincoln

About: University of Lincoln is a education organization based out in Lincoln, Lincolnshire, United Kingdom. It is known for research contribution in the topics: Population & Higher education. The organization has 2341 authors who have published 7025 publications receiving 124797 citations.

Metal-Organic Framework Nanoparticle-Assisted Cryopreservation of Red Blood Cells.

Abstract: The development of hybrid nanomaterials mimicking antifreeze proteins that can modulate/inhibit the growth of ice crystals for cell/tissue cryopreservation has attracted increasing interests. Herein, we describe the first utilization of zirconium (Zr)-based metal-organic framework (MOF) nanoparticles (NPs) with well-defined surface chemistries for the cryopreservation of red blood cells (RBCs) without the need of any (toxic) organic solvents. Distinguishing features of this cryoprotective approach include the exceptional water stability, low hemolytic activity, and the long periodic arrangement of organic linkers on the surface of MOF NPs, which provide a precise spacing of hydrogen donors to recognize and match the ice crystal planes. Five kinds of Zr-based MOF NPs, with different pore size, surface chemistry, and framework topologies, were used for the cryoprotection of RBCs. A "splat" assay confirmed that MOF NPs not only exhibited ice recrystallization inhibition activities but also acted as a "catalyst" to accelerate the melting of ice crystals. The human RBC cryopreservation tests displayed RBC recoveries of up to ∼40%, which is higher than that obtained via commonly used hydroxyethyl starch polymers. This cryopreservation approach will inspire the design and utilization of MOF-derived nanoarchitectures for the effective cryopreservation of various cell types as well as tissue samples.

The Education of Radical Democracy

Abstract: The Education of Radical Democracy explores why radical democracy is so necessary, difficult, and possible and why it is important to understand it as an educative activity . The book draws on critical social theory and critical pedagogy to explain what enables and sustains work for radical democratization, and considers how we can begin such work in neoliberal societies today. Exploring examples of projects from the nineteenth century to the present day, the book sheds light on a wealth of critical tools, research studies, theoretical concepts and practical methods. It offers a critical reading of the ‘crisis of hope’ in neoliberal capitalist societies, focusing on the problem of the ‘contraction of possibilities’ for democratic agency, resistance to domination, and practices of freedom. It argues that radically democratic thinking, practice, and forms of social organization are vital for countering and overcoming systemic hegemonies and that these can be learned and cultivated. This book will be of interest to academics, practitioners, researchers, and students in education and critical theory, and to those interested in the sociology, philosophy and politics of hope. It also invites new dialogues between theorists of neoliberal power and political possibility, those engaged in projects for radical democratization, and teachers in formal and informal educational settings.

Epigenetic regulation of the placental HSD11B2 barrier and its role as a critical regulator of fetal development.

Abstract: "Fetal programming" is a term used to describe how early-life experience influences fetal development and later disease risk. In humans, prenatal stress-induced fetal programming is associated with increased risk of preterm birth, and a heightened risk of metabolic and neurological diseases later in life. A critical determinant of this is the regulation of fetal exposure to glucocorticoids by the placenta. Glucocorticoids are the mediators through which maternal stress influences fetal development. Excessive fetal glucocorticoid exposure during pregnancy results in low birth weight and abnormalities in a number of tissues. The amount of fetal exposure to maternal glucocorticoids depends on the expression of HSD11B2, an enzyme predominantly produced by the syncytiotrophoblast in the placenta. This protects the fetus by converting active glucocorticoids into inactive forms. In this review we examine recent findings regarding placental HSD11B2 that suggest that its epigenetic regulation may mechanistically link maternal stress and long-term health consequences in affected offspring.

A case study in leading schools for social justice: when morals and markets collide

Abstract: Purpose – This paper explores how school leaders seek to promote social justice agendas within the context of multi‐ethnic schools in England.Design/methodology/approach – The paper draws on data from five case‐study secondary schools in England. Qualitative data was derived from interviewing principals in each institution together with interviews with staff, students and members of the wider community.Findings – Effective principals in multi‐ethnic schools had strong values commitments to social justice and were able to articulate these values across and through the policies and practices in their schools. However, in some cases value commitments to equity and inclusivity could be challenged by the consequences of policies promoting school choice and the development of a quasi‐market for school education. This could present school leaders with complex moral dilemmas that counter posed inclusion aspirations against performance in the local market.Originality/value – School leadership committed to promotin...