Institution
University of Lisbon
Education•Lisbon, Lisboa, Portugal•
About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.
Papers published on a yearly basis
Papers
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TL;DR: The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks and EU-ROS represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine.
Abstract: The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed
242 citations
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TL;DR: A mathematical model describing the dynamics of the Notch signalling pathway during chick embryo gastrulation is presented, which reveals a complex and highly robust genetic network that locally activates Notch on the left side of Hensen's node.
Abstract: During vertebrate embryo development, the breaking of the initial bilateral symmetry is translated into asymmetric gene expression around the node and/or in the lateral plate mesoderm. The earliest conserved feature of this asymmetric gene expression cascade is the left-sided expression of Nodal, which depends on the activity of the Notch signalling pathway. Here we present a mathematical model describing the dynamics of the Notch signalling pathway during chick embryo gastrulation, which reveals a complex and highly robust genetic network that locally activates Notch on the left side of Hensen's node. We identify the source of the asymmetric activation of Notch as a transient accumulation of extracellular calcium, which in turn depends on left-right differences in H+/K+-ATPase activity. Our results uncover a mechanism by which the Notch signalling pathway translates asymmetry in epigenetic factors into asymmetric gene expression around the node.
242 citations
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TL;DR: Hox genes seem to differentially orchestrate posterior expansion of embryonic tissues during axial morphogenesis as an integral part of their function in specifying head-to-tail identity.
242 citations
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University of Duisburg-Essen1, Queen Mary University of London2, University of Natural Resources and Life Sciences, Vienna3, Institut national de la recherche agronomique4, Swedish University of Agricultural Sciences5, University of Hull6, Finnish Environment Institute7, Royal Museum for Central Africa8, Botanic Garden Meise9, University of Lisbon10, Imperial College London11, Durham University12
TL;DR: Overall, suitability of DNA-based identification is particularly high for fish, as eDNA is a well-suited sampling approach which can replace expensive and potentially harmful methods such as gill-netting, trawling or electrofishing.
242 citations
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TL;DR: In this article, a comparison between modern terrestrial and marine pollen signals in and off western Iberia shows that marine pollen assemblages give an integrated image of the regional vegetation colonising the adjacent continent.
241 citations
Authors
Showing all 19716 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joao Seixas | 153 | 1538 | 115070 |
A. Gomes | 150 | 1862 | 113951 |
Marco Costa | 146 | 1458 | 105096 |
António Amorim | 136 | 1477 | 96519 |
Osamu Jinnouchi | 135 | 885 | 86104 |
P. Verdier | 133 | 1111 | 83862 |
Andy Haas | 132 | 1096 | 87742 |
Wendy Taylor | 131 | 1252 | 89457 |
Steve McMahon | 130 | 878 | 78763 |
Timothy Andeen | 129 | 1069 | 77593 |
Heather Gray | 129 | 966 | 80970 |
Filipe Veloso | 128 | 887 | 75496 |
Nuno Filipe Castro | 128 | 960 | 76945 |
Oliver Stelzer-Chilton | 128 | 1141 | 79154 |
Isabel Marian Trigger | 128 | 974 | 77594 |