Institution
University of Lisbon
Education•Lisbon, Lisboa, Portugal•
About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & European union. The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.
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University of Rochester1, University of Washington2, Food and Drug Administration3, University of Pennsylvania4, Queen's University5, Tufts University6, Johns Hopkins University7, California Pacific Medical Center8, University of Wisconsin-Madison9, University of Kiel10, University of Queensland11, Bristol-Myers Squibb12, Johnson & Johnson13, Pfizer14, Eisai15, Yale University16, United States Department of Veterans Affairs17, Endo International plc18, AstraZeneca19, Purdue Pharma20, National Institutes of Health21, Imperial College London22, University of Lisbon23, Eli Lilly and Company24, Oregon Health & Science University25, Grünenthal GmbH26, Harvard University27, University of Ottawa28, Smith & Nephew29, University of Düsseldorf30
TL;DR: The authors recommend consideration of a number of patient, study design, study site, and outcome measurement factors that have the potential to affect the assay sensitivity of RCTs of chronic pain treatments.
Abstract: A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs) have failed to show statistically significant superiority to placebo in conditions in which their efficacy had previously been demonstrated. Assuming the validity of previous evidence of efficacy and the comparability of the patients and outcome measures in these studies, such results may be a consequence of limitations in the ability of these RCTs to demonstrate the benefits of efficacious analgesic treatments vs placebo ("assay sensitivity"). Efforts to improve the assay sensitivity of analgesic trials could reduce the rate of falsely negative trials of efficacious medications and improve the efficiency of analgesic drug development. Therefore, an Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials consensus meeting was convened in which the assay sensitivity of chronic pain trials was reviewed and discussed. On the basis of this meeting and subsequent discussions, the authors recommend consideration of a number of patient, study design, study site, and outcome measurement factors that have the potential to affect the assay sensitivity of RCTs of chronic pain treatments. Increased attention to and research on methodological aspects of clinical trials and their relationships with assay sensitivity have the potential to provide the foundation for an evidence-based approach to the design of analgesic clinical trials and expedite the identification of analgesic treatments with improved efficacy and safety.
238 citations
TL;DR: In this paper, the authors evaluated the relative contributions of cancer staging, duration and diet on patients' nutritional deterioration and found significant associations for tumour location, disease duration, nutritional intake, and previous surgery or chemotherapy.
238 citations
Bjerknes Centre for Climate Research1, Aristotle University of Thessaloniki2, Central Institution for Meteorology and Geodynamics3, Charles University in Prague4, Norwegian Meteorological Institute5, Danish Meteorological Institute6, Met Office7, University of Oxford8, University of Lisbon9, University of Cantabria10, University of Copenhagen11, International Centre for Theoretical Physics12, Royal Meteorological Institute13, ETH Zurich14, Agencia Estatal de Meteorología15, Maynooth University16, University of Castilla–La Mancha17, Forschungszentrum Jülich18, University of Murcia19, Spanish National Research Council20, Croatian Meteorological and Hydrological Service21, Brandenburg University of Technology22, Swedish Meteorological and Hydrological Institute23, University of Bonn24, MeteoSwiss25, University of Graz26, Royal Netherlands Meteorological Institute27, Central Maine Community College28, Université Paris-Saclay29, Karlsruhe Institute of Technology30, Finnish Meteorological Institute31, National Center for Atmospheric Research32, University of Toulouse33, Ghent University34, University of Hohenheim35
TL;DR: The European CORDEX (EURO-CORDEX) initiative as discussed by the authors is a large voluntary effort that seeks to advance regional climate and Earth system science in Europe, which includes the design and coordination of ongoing ensembles of regional climate projections of unprecedented size and resolution.
Abstract: The European CORDEX (EURO-CORDEX) initiative is a large voluntary effort that seeks to advance regional climate and Earth system science in Europe. As part of the World Climate Research Programme (WCRP) - Coordinated Regional Downscaling Experiment (CORDEX), it shares the broader goals of providing a model evaluation and climate projection framework and improving communication with both the General Circulation Model (GCM) and climate data user communities. EURO-CORDEX oversees the design and coordination of ongoing ensembles of regional climate projections of unprecedented size and resolution (0.11° EUR-11 and 0.44° EUR-44 domains). Additionally, the inclusion of empirical-statistical downscaling allows investigation of much larger multi-model ensembles. These complementary approaches provide a foundation for scientific studies within the climate research community and others. The value of the EURO-CORDEX ensemble is shown via numerous peer-reviewed studies and its use in the development of climate services. Evaluations of the EUR-44 and EUR-11 ensembles also show the benefits of higher resolution. However, significant challenges remain. To further advance scientific understanding, two flagship pilot studies (FPS) were initiated. The first investigates local-regional phenomena at convection-permitting scales over central Europe and the Mediterranean in collaboration with the Med-CORDEX community. The second investigates the impacts of land cover changes on European climate across spatial and temporal scales. Over the coming years, the EURO-CORDEX community looks forward to closer collaboration with other communities, new advances, supporting international initiatives such as the IPCC reports, and continuing to provide the basis for research on regional climate impacts and adaptation in Europe.
237 citations
TL;DR: The data presented here clearly highlight the complexity of using adenosinergic agents therapeutically in PD and other neurodegenerative disorders and point out many areas for further inquiry, and confirm that adenosine receptor ligands, particularly A2A receptor ligand, have many promising characteristics that encourage the pursuit of their therapeutic potential.
237 citations
University of Würzburg1, National University of Comahue2, Spanish National Research Council3, Swedish University of Agricultural Sciences4, Universidade Federal de Goiás5, University of Lisbon6, Stanford University7, Commonwealth Scientific and Industrial Research Organisation8, National University of Río Negro9, ETH Zurich10, Cornell University11, University of California, Davis12, The Nature Conservancy13, Wageningen University and Research Centre14, University of British Columbia15, Great Lakes Bioenergy Research Center16, University of California, Berkeley17, University of Padua18, University of New England (United States)19, Lund University20, University of Göttingen21, University of La Rochelle22, Institut national de la recherche agronomique23, Federal University of Ceará24, Concordia University Wisconsin25, University of Belgrade26, National University of Tucumán27, Michigan State University28, University of Brasília29, University of Greenwich30, University of Reading31, University of Wisconsin-Madison32, Boise State University33, University of Texas at Austin34, University of Haifa35, Kansas State University36, University of Freiburg37, University of Hamburg38, University of California, Santa Barbara39, Seattle University40, University of Vienna41, University of Florida42, Centro Agronómico Tropical de Investigación y Enseñanza43, National Audubon Society44, University of Buenos Aires45, Virginia Tech46, University of Bordeaux47, University of Auckland48, University College Dublin49, Trinity College, Dublin50, University of Tokyo51, Federal University of Bahia52, Lincoln University (Pennsylvania)53, National Institute for Environmental Studies54, International Food Policy Research Institute55, Xi'an Jiaotong-Liverpool University56
TL;DR: Using a global database from 89 crop systems, the relative importance of abundance and species richness for pollination, biological pest control and final yields in the context of on-going land-use change is partitioned.
Abstract: Human land use threatens global biodiversity and compromises multiple ecosystem functions critical to food production. Whether crop yield-related ecosystem services can be maintained by few abundant species or rely on high richness remains unclear. Using a global database from 89 crop systems, we partition the relative importance of abundance and species richness for pollination, biological pest control and final yields in the context of on-going land-use change. Pollinator and enemy richness directly supported ecosystem services independent of abundance. Up to 50% of the negative effects of landscape simplification on ecosystem services was due to richness losses of service-providing organisms, with negative consequences for crop yields. Maintaining the biodiversity of ecosystem service providers is therefore vital to sustain the flow of key agroecosystem benefits to society.
237 citations
Authors
Showing all 19716 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Joao Seixas | 153 | 1538 | 115070 |
| A. Gomes | 150 | 1862 | 113951 |
| Marco Costa | 146 | 1458 | 105096 |
| António Amorim | 136 | 1477 | 96519 |
| Osamu Jinnouchi | 135 | 885 | 86104 |
| P. Verdier | 133 | 1111 | 83862 |
| Andy Haas | 132 | 1096 | 87742 |
| Wendy Taylor | 131 | 1252 | 89457 |
| Steve McMahon | 130 | 878 | 78763 |
| Timothy Andeen | 129 | 1069 | 77593 |
| Heather Gray | 129 | 966 | 80970 |
| Filipe Veloso | 128 | 887 | 75496 |
| Nuno Filipe Castro | 128 | 960 | 76945 |
| Oliver Stelzer-Chilton | 128 | 1141 | 79154 |
| Isabel Marian Trigger | 128 | 974 | 77594 |