University of Lisbon

About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & European union. The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.

Cytogenetic Prognostication Within Medulloblastoma Subgroups

Abstract: Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication.

Cognitive function in primary progressive and transitional progressive multiple sclerosis: a controlled study with MRI correlates.

Abstract: The relative rarity of primary progressive (PP) and transitional progressive (TP) multiple sclerosis has meant that little documentation of cognitive function in such patients is currently available. The aim of this study was to investigate the cognitive skills of patients with PP and TP multiple sclerosis relative to matched healthy controls, and to examine the relationship of this impairment to MRI parameters. Sixty-three patients (43 PP, 20 TP) were individually matched with healthy controls, who undertook the same cognitive tasks as the patient group. The neuropsychological assessment comprised Rao's brief repeatable battery, a reasoning test, and a measure of depression. Patients also underwent T1- and T2-weighted brain MRI. These patients were taken from a larger cohort (158 PP, 33 TP) in whom it had been demonstrated that the re were no significant differences between the mean scores of the PP and TP groups on any of the cognitive variables. The 63 patients were therefore taken as one group for comparison with the healthy controls. These patients performed significantly worse than the controls in tests of verbal memory, attention, verbal fluency and spatial reasoning. An impairment index was constructed and applied to the patient data. This correlated modestly with T2-lesion load ( r = 0.45, P = 0.01), T1-hypointensity load ( r = 0.45, P = 0.01) and cerebral volume ( r = –0.35, P = 0.01). Thus, PP and TP multiple sclerosis patients demonstrate significant cognitive dysfunction when compared with matched healthy controls. The relationship between this impairment and MRI parameters is moderate, suggesting that cognitive dysfunction in PP and TP multiple sclerosis has a complex and multifactorial aetiology, which is not adequately explained by pathology as demonstrated on conventional MRI.

ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider

Abstract: This paper reviews and extends searches for the direct pair production of the scalar supersymmetric partners of the top and bottom quarks in proton-proton collisions collected by the ATLAS collaboration during the LHC Run 1. Most of the analyses use 20 [Formula: see text] of collisions at a centre-of-mass energy of [Formula: see text] TeV, although in some case an additional [Formula: see text] of collision data at [Formula: see text] TeV are used. New analyses are introduced to improve the sensitivity to specific regions of the model parameter space. Since no evidence of third-generation squarks is found, exclusion limits are derived by combining several analyses and are presented in both a simplified model framework, assuming simple decay chains, as well as within the context of more elaborate phenomenological supersymmetric models.

Measuring semantic similarity between Gene Ontology terms

Abstract: Many bioinformatics applications would benefit from comparing proteins based on their biological role rather than their sequence. This paper adds two new contributions. First, a study of the correlation between Gene Ontology (GO) terms and family similarity demonstrates that protein families constitute an appropriate baseline for validating GO similarity. Secondly, we introduce GraSM, a novel method that uses all the information in the graph structure of the Gene Ontology, instead of considering it as a hierarchical tree. GraSM gives a consistently higher family similarity correlation on all aspects of GO than the original semantic similarity measures.

The Outstanding 2004/05 Drought in the Iberian Peninsula: Associated Atmospheric Circulation

Abstract: The 2004/05 hydrological year (October 2004 to September 2005) was characterized by intense dry conditions affecting most of western Europe (35°–55°N and 10°W–10°E). In Iberia the drought affected every month of this period, with the southern half of Iberia receiving roughly 40% of the usual precipitation by June 2005. Moreover, this episode stands as the driest event in the last 140 yr, producing major socioeconomic impacts particularly due to the large decrease in hydroelectricity and agricultural production in both Iberian countries (Portugal and Spain). To assess the atmospheric submonthly circulation associated with this drought an Eulerian [weather types (WTs)] and a Lagrangean (objective storm tracks) analysis were combined. There was a dramatic drop in “wet” WT frequency during winter, with less than 50% of the normal value, and a corresponding increase of “dry” WTs. The storm-track analysis reveals an impressive northward displacement of cyclone trajectories in the North Atlantic sector in winter months, resulting in an almost complete absence of cyclones crossing Iberia and western Europe. At the monthly scale, the intense drought in Iberia was due to a combination of different physical mechanisms. First, the scarce precipitation observed between November 2004 and January 2005 was associated with positive North Atlantic Oscillation (NAO) indexes for these months. In February, the East Atlantic (EA) pattern seems to be the main driver. In March neither the negative NAO (1.8) nor the positive EA (1.1) are capable of explaining the large negative precipitation anomalies. However, it is shown that during March 2005, an intense and anomalous blocking was displaced southward of its usual location, inhibiting the occurrence of precipitation over Iberia and leading to a negative NAO index anomalously associated with low precipitation records.