University of Lisbon

About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & European union. The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.

Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study

Abstract: Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.

Cosmic shear analysis with CFHTLS deep data

Abstract: We present the first cosmic shear measurements obtained from the T0001 release of the Canada-France-Hawaii Telescope Legacy Survey. The data set covers three uncorrelated patches (D1, D3 and D4) of one square degree each, observed in u*, g', r', i' and z' bands, to a depth of i' = 25.5. The deep, multi-colour observations in these fields allow for several data-quality controls. The lensing signal is detected in both r' and i' bands and shows similar amplitude and slope in both filters. B-modes are found to be statistically zero at all scales. Using multi-colour information, we derived a photometric redshift for each galaxy and use this to separate the background source sample into low-z and high-z subsamples. A stronger shear signal is detected from the high-z subsample than from the low-z subsample, as expected from weak lensing tomography. While further work is needed to model the effects of errors in the photometric redshifts, this result suggests that it will be possible to obtain constraints on the growth of dark matter fluctuations with lensing wide field surveys. The combined Deep and Wide surveys give σ 8 = 0.89 ± 0.06 assuming the Peacock & Dodds non-linear scheme (P&D), and σ 8 = 0.86 ± 0.05 for the halo model and Ω m = 0.3. We assumed a Cold Dark Matter model with flat geometry and have marginalized over the systematics, the Hubble constant and redshift uncertainties. Using data from the Deep survey, the 1σ upper bound for ω 0 , the constant equation of state parameter is ω 0 < -0.8.

Vector rogue waves in binary mixtures of Bose-Einstein condensates

Abstract: We study numerically rogue waves in the two-component Bose-Einstein condensates which are described by the coupled set of two Gross-Pitaevskii equations with variable scattering lengths. We show that rogue wave solutions exist only for certain combinations of the nonlinear coefficients describing two-body interactions. We present the solutions for the combinations of these coefficients that admit the existence of rogue waves.

A Common Genetic Origin for Early Farmers from Mediterranean Cardial and Central European LBK Cultures

Abstract: The spread of farming out of the Balkans and into the rest of Europe followed two distinct routes: An initial expansion represented by the Impressa and Cardial traditions, which followed the Northern Mediterranean coastline; and another expansion represented by the LBK (Linearbandkeramik) tradition, which followed the Danube River into Central Europe. Although genomic data now exist from samples representing the second migration, such data have yet to be successfully generated from the initial Mediterranean migration. To address this, we generated the complete genome of a 7,400-yearold Cardial individual (CB13) from Cova Bonica in Vallirana (Barcelona), as well as partial nuclear data from five others excavated from different sites in Spain and Portugal. CB13 clusters with all previously sequenced early European farmers and modern-day Sardinians. Furthermore, our analyses suggest that both Cardial and LBK peoples derived from a common ancient population located in or around the Balkan Peninsula. The Iberian Cardial genome also carries a discernible hunter‐gatherer genetic signature that likely was not acquired by admixture with local Iberian foragers. Our results indicate that retrieving ancient genomes from similarly warm Mediterranean environments such as the Near East is technically feasible.

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

Abstract: Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier