Institution
University of Lisbon
Education•Lisbon, Lisboa, Portugal•
About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.
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TL;DR: The dye photodecolorization process was studied considering the influence of experimental parameters such as catalyst concentration, TiO2/ZnS ratio, pH and methylene blue adsorption rate.
167 citations
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TL;DR: In this article, the authors measured the relationship between net ecosystem exchange of carbon and climate factors using the eddy covariance method at 125 unique sites in various ecosystems over six continents with a total of 559 site-years.
Abstract: Understanding the relationships between climate and carbon exchange by terrestrial ecosystems is critical to predict future levels of atmospheric carbon dioxide because of the potential accelerating effects of positive climate–carbon cycle feedbacks. However, directly observed relationships between climate and terrestrial CO2 exchange with the atmosphere across biomes and continents are lacking. Here we present data describing the relationships between net ecosystem exchange of carbon (NEE) and climate factors as measured using the eddy covariance method at 125 unique sites in various ecosystems over six continents with a total of 559 site-years. We find that NEE observed at eddy covariance sites is (1) a strong function of mean annual temperature at mid- and high-latitudes, (2) a strong function of dryness at mid- and low-latitudes, and (3) a function of both temperature and dryness around the mid-latitudinal belt (45°N). The sensitivity of NEE to mean annual temperature breaks down at ~ 16 °C (a threshold value of mean annual temperature), above which no further increase of CO2 uptake with temperature was observed and dryness influence overrules temperature influence.
167 citations
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TL;DR: In this paper, the authors deal with the asymptotic and finite sample properties of ρ estimators of the tail index γ, based on external estimators, and show that the behavior of the ρ-estimator considered has a high impact on the distributional properties of the final estimator.
Abstract: In this paper we shall deal with the asymptotic and finite sample properties of “asymptotically unbiased” estimators of the tail index γ, based on “external” adequate estimators of the second order parameter ρ. The behavior of the ρ-estimator considered has indeed a high impact on the distributional properties of the final estimator of γ, and must be carefully chosen. As a by-product of the final study we present also the finite sample properties of a few ρ-estimators available in the literature.
167 citations
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TL;DR: In this article, a procedure for estimating the photovoltaic (PV) potential of an urban region from LiDAR data using the Solar Analyst tool is described, and it is shown that for a low PV penetration (about 10% of total roof area) the PV potential can be well estimated by considering no shade and local optimum inclination and orientation.
167 citations
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TL;DR: The development of targeted nanodelivery systems in which therapeutic and imaging agents are merged into a single platform is an attractive strategy, and several nanoplatform-based formulations, such as polymeric nanoparticles, micelles, liposomes and dendrimers are in preclinical and clinical stages of development.
Abstract: Cancer is one of the most common diseases afflicting people globally. New therapeutic approaches are needed due to the complexity of cancer as a disease. Many current treatments are very toxic and have modest efficacy at best. Increased understanding of tumor biology and immunology has allowed the development of specific immunotherapies with minimal toxicity. It is important to highlight the performance of monoclonal antibodies, immune adjuvants, vaccines and cell-based treatments. Although these approaches have shown varying degrees of clinical efficacy, they illustrate the potential to develop new strategies. Targeted immunotherapy is being explored to overcome the heterogeneity of malignant cells and the immune suppression induced by both the tumor and its microenvironment. Nanodelivery strategies seek to minimize systemic exposure to target therapy to malignant tissue and cells. Intracellular penetration has been examined through the use of functionalized particulates. These nano-particulate associated medicines are being developed for use in imaging, diagnostics and cancer targeting. Although nano-particulates are inherently complex medicines, the ability to confer, at least in principle, different types of functionality allows for the plausible consideration these nanodelivery strategies can be exploited for use as combination medicines. The development of targeted nanodelivery systems in which therapeutic and imaging agents are merged into a single platform is an attractive strategy. Currently, several nanoplatform-based formulations, such as polymeric nanoparticles, micelles, liposomes and dendrimers are in preclinical and clinical stages of development. Herein, nanodelivery strategies presently investigated for cancer immunotherapy, cancer targeting mechanisms and nanocarrier functionalization methods will be described. We also intend to discuss the emerging nano-based approaches suitable to be used as imaging techniques and as cancer treatment options.
167 citations
Authors
Showing all 19716 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joao Seixas | 153 | 1538 | 115070 |
A. Gomes | 150 | 1862 | 113951 |
Marco Costa | 146 | 1458 | 105096 |
António Amorim | 136 | 1477 | 96519 |
Osamu Jinnouchi | 135 | 885 | 86104 |
P. Verdier | 133 | 1111 | 83862 |
Andy Haas | 132 | 1096 | 87742 |
Wendy Taylor | 131 | 1252 | 89457 |
Steve McMahon | 130 | 878 | 78763 |
Timothy Andeen | 129 | 1069 | 77593 |
Heather Gray | 129 | 966 | 80970 |
Filipe Veloso | 128 | 887 | 75496 |
Nuno Filipe Castro | 128 | 960 | 76945 |
Oliver Stelzer-Chilton | 128 | 1141 | 79154 |
Isabel Marian Trigger | 128 | 974 | 77594 |