Institution
University of Lisbon
Education•Lisbon, Lisboa, Portugal•
About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & European union. The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.
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TL;DR: Analysis of two breast cancer patient cohorts revealed that altered modularity of the human interactome may be useful as an indicator of breast cancer prognosis.
Abstract: Changes in the biochemical wiring of oncogenic cells drives phenotypic transformations that directly affect disease outcome. Here we examine the dynamic structure of the human protein interaction network (interactome) to determine whether changes in the organization of the interactome can be used to predict patient outcome. An analysis of hub proteins identified intermodular hub proteins that are co-expressed with their interacting partners in a tissue-restricted manner and intramodular hub proteins that are co-expressed with their interacting partners in all or most tissues. Substantial differences in biochemical structure were observed between the two types of hubs. Signaling domains were found more often in intermodular hub proteins, which were also more frequently associated with oncogenesis. Analysis of two breast cancer patient cohorts revealed that altered modularity of the human interactome may be useful as an indicator of breast cancer prognosis.
742 citations
TL;DR: Solid lipid particulate systems such as solid lipid nanoparticles (SLN), lipid microparticles (LM) and lipospheres) seem to fulfil the requirements for an optimum particulate carrier system for therapeutic peptides, proteins and antigens.
742 citations
Goethe University Frankfurt1, University of Maryland, College Park2, University of Guelph3, Duke University4, Swedish University of Agricultural Sciences5, Radboud University Nijmegen6, Federal University of Mato Grosso do Sul7, University of Alberta8, Royal Veterinary College9, Wildlife Conservation Society10, Mississippi State University11, Sao Paulo State University12, Michigan Department of Natural Resources13, University of California, Davis14, Aarhus University15, Max Planck Society16, University of Potsdam17, Middle Tennessee State University18, Mammal Research Institute19, Harvard University20, Edmund Mach Foundation21, Smithsonian Conservation Biology Institute22, University of Évora23, University of Montpellier24, Parks Victoria25, Monash University26, Ohio State University27, Fiji National University28, University of Massachusetts Amherst29, United States Geological Survey30, Save the Elephants31, University of Oxford32, German Primate Center33, Technische Universität München34, Institute of Ecosystem Studies35, University of British Columbia36, University of Zurich37, University of Wyoming38, University of Washington39, University of Montana40, Bavarian Forest National Park41, University of Freiburg42, University of Toulouse43, University of Veterinary Medicine Vienna44, University College Cork45, North Carolina State University46, North Carolina Museum of Natural Sciences47, Karatina University48, University of Lethbridge49, Lamont–Doherty Earth Observatory50, University of Valencia51, Stony Brook University52, International Union for Conservation of Nature and Natural Resources53, University of Alicante54, Empresa Brasileira de Pesquisa Agropecuária55, University of Glasgow56, New York University57, University of Oslo58, Hebrew University of Jerusalem59, Norwegian University of Science and Technology60, Field Museum of Natural History61, University of Bayreuth62, University of Grenoble63, University of New South Wales64, Pennsylvania Game Commission65, Princeton University66, University of Konstanz67, University of Haifa68, Polish Academy of Sciences69, Instituto Superior de Agronomia70, University of Porto71, University of Lisbon72, University of California, Santa Cruz73, University of Pretoria74, Colorado State University75
TL;DR: Using a unique GPS-tracking database of 803 individuals across 57 species, it is found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in area with a low human footprint.
Abstract: Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.
719 citations
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TL;DR: In this paper, the authors compute public sector performance (PSP) and efficiency (PSE) indicators, comprising a composite and seven sub-indicators, for 23 industrialised countries.
Abstract: We compute public sector performance (PSP) and efficiency (PSE) indicators, comprising a composite and seven sub-indicators, for 23 industrialised countries. The first four sub-indicators are "opportunity" indicators that take into account administrative, education and health outcomes and the quality of public infrastructure and that support the rule of law and a level playing-field in a market economy. Three other indicators reflect the standard "Musgravian" tasks for government: allocation, distribution, and stabilisation. The input and output efficiency of public sectors across countries is then measured via a non-parametric production frontier technique.
717 citations
TL;DR: Calculated values are comparable to those used in the most recent in vitro studies on modulation of neuronal activity and may be used to assess the current distribution during tDCS using new electrode montages, to help optimize montages that target a specific region of the brain or to preliminarily investigate compliance with safety guidelines.
713 citations
Authors
Showing all 19716 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Joao Seixas | 153 | 1538 | 115070 |
| A. Gomes | 150 | 1862 | 113951 |
| Marco Costa | 146 | 1458 | 105096 |
| António Amorim | 136 | 1477 | 96519 |
| Osamu Jinnouchi | 135 | 885 | 86104 |
| P. Verdier | 133 | 1111 | 83862 |
| Andy Haas | 132 | 1096 | 87742 |
| Wendy Taylor | 131 | 1252 | 89457 |
| Steve McMahon | 130 | 878 | 78763 |
| Timothy Andeen | 129 | 1069 | 77593 |
| Heather Gray | 129 | 966 | 80970 |
| Filipe Veloso | 128 | 887 | 75496 |
| Nuno Filipe Castro | 128 | 960 | 76945 |
| Oliver Stelzer-Chilton | 128 | 1141 | 79154 |
| Isabel Marian Trigger | 128 | 974 | 77594 |