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Institution

University of Lisbon

EducationLisbon, Lisboa, Portugal
About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & European union. The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.


Papers
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Journal ArticleDOI
J. Abraham1, P. Abreu2, Marco Aglietta3, Marco Aglietta4  +480 moreInstitutions (79)
TL;DR: In this paper, the Pierre Auger Observatory data was used to confirm the anisotropy of the arrival direction of the highest-energy cosmic rays with the highest energy, which are correlated with the positions of relatively nearby active galactic nuclei (AGN) at a confidence level of more than 99%.

415 citations

Journal ArticleDOI
TL;DR: In the 3E (Evidence, Expertise, Exchange) Initiative of 2007-8, 751 rheumatologists from 17 countries participated in three separate rounds of discussions and Delphi votes as mentioned in this paper.
Abstract: Objectives: To develop evidence-based recommendations for the use of methotrexate in daily clinical practice in rheumatic disorders. Methods: 751 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2007–8 consisting of three separate rounds of discussions and Delphi votes. Ten clinical questions concerning the use of methotrexate in rheumatic disorders were formulated. A systematic literature search in Medline, Embase, Cochrane Library and 2005–7 American College of Rheumatology/European League Against Rheumatism meeting abstracts was conducted. Selected articles were systematically reviewed and the evidence was appraised according to the Oxford levels of evidence. Each country elaborated a set of national recommendations. Finally, multinational recommendations were formulated and agreement among the participants and the potential impact on their clinical practice was assessed. Results: A total of 16 979 references was identified, of which 304 articles were included in the systematic reviews. Ten multinational key recommendations on the use of methotrexate were formulated. Nine recommendations were specific for rheumatoid arthritis (RA), including the work-up before initiating methotrexate, optimal dosage and route, use of folic acid, monitoring, management of hepatotoxicity, long-term safety, mono versus combination therapy and management in the perioperative period and before/during pregnancy. One recommendation concerned methotrexate as a steroid-sparing agent in other rheumatic diseases. Conclusions: Ten recommendations for the use of methotrexate in daily clinical practice focussed on RA were developed, which are evidence based and supported by a large panel of rheumatologists, enhancing their validity and practical use.

415 citations

Journal ArticleDOI
TL;DR: Nurses' supervisors with a transformational leadership style enhance different 'extra-role' performance in nurses and this increases hospital efficacy by establishing a sense of self-efficacy but also by amplifying their levels of engagement in the workplace.
Abstract: salanova m., lorente l., chambel m.j. & martinez i.m. (2011) Linking transformational leadership to nurses’ extra-role performance: the mediating role of self-efficacy and work engagement. Journal of Advanced Nursing 67(9), 2256–2266. Abstract Aims. This paper is a report of a social cognitive theory-guided study about the link between supervisors’ transformational leadership and staff nurses’ extra-role performance as mediated by nurse self-efficacy and work engagement. Background. Past research has acknowledged the positive influence that transformational leaders have on employee (extra-role) performance. However, less is known about the psychological mechanisms that may explain the links between transformational leaders and extra-role performance, which encompasses behaviours that are not considered formal job requirements, but which facilitate the smooth functioning of the organization as a social system. Methods. Seventeen supervisors evaluated nurses’ extra-role performance, the data generating a sample consisting of 280 dyads. The nurses worked in different health services in a large Portuguese hospital and the participation rate was 76·9% for nurses and 100% for supervisors. Data were collected during 2009. A theory-driven model of the relationships between transformation leadership, self-efficacy, work engagement and nurses’ extra-role performance was tested using Structural Equation Modelling. Results. Data analysis revealed a full mediation model in which transformational leadership explained extra-role performance through self-efficacy and work engagement. A direct relationship between transformational leadership and work engagement was also found. Conclusion. Nurses’ supervisors with a transformational leadership style enhance different ‘extra-role’ performance in nurses and this increases hospital efficacy. They do so by establishing a sense of self-efficacy but also by amplifying their levels of engagement in the workplace.

411 citations

Journal ArticleDOI
TL;DR: In this article, Fourier transform infrared absorption spectroscopy has been used to characterize the structure of porous silica gel films, both deposited on c-Si substrates and free standing.
Abstract: Fourier transform infrared absorption spectroscopy has been utilized to characterize the structure of porous silica gel films, both deposited on c‐Si substrates and free standing. The films were either dried at room temperature or subjected to partial densification at 400–450 °C. The spectra of the gel films are compared to those of thermal SiO2 grown on c‐Si and to Kramers–Kronig analysis of the reflection spectra of bulk SiO2 gels and v‐SiO2. The gel films show small frequency shifts compared to the latter spectra and they also exhibit new bands due to the presence of OH groups, although very little molecular water or residual organic species were found. The results are interpreted in terms of the gel structure. Compared to the thermal oxide, the sharp peak near 1070 cm−1 is narrower for the gels and the spread in intertetrahedral angles is estimated at 24° and 27° for room temperature dried and partially densified gels, respectively, compared to 33° for the thermal oxide. This is in agreement with a st...

410 citations

Journal ArticleDOI
TL;DR: The role of neuroinflammation in the emergence of depression is discussed, namely dynamic alterations in the status of microglia response to stimulation, and how their activation phenotypes may have an etiological role in neurodegeneneration, in particular in depressive-like behavior.
Abstract: Patients with chronic inflammation are often associated with the emergence of depression symptoms, while diagnosed depressed patients show increased levels of circulating cytokines. Further studies revealed the activation of the brain immune cell microglia in depressed patients with a greater magnitude in individuals that committed suicide, indicating a crucial role for neuroinflammation in depression brain pathogenesis. Rapid advances in the understanding of microglial and astrocytic neurobiology were obtained in the past fifteen to twenty years. Indeed, recent data reveal that microglia play an important role in managing neuronal cell death, neurogenesis, and synaptic interactions, besides their involvement in immune-response generating cytokines. The communication between microglia and neurons is essential to synchronize these diverse functions with brain activity. Evidence is accumulating that secreted extracellular vesicles (EVs), comprising ectosomes and exosomes with a size ranging from 0.1 to 1 μm, are key players in intercellular signaling. These EVs may carry specific proteins, mRNAs and microRNAs (miRNAs). Transfer of exosomes to neurons was shown to be mediated by oligodendrocytes, microglia and astrocytes that may either be supportive to neurons, or instead disseminate the disease. Interestingly, several recent reports have identified changes in miRNAs in depressed patients, which target not only crucial pathways associated with synaptic plasticity, learning and memory but also the production of neurotrophic factors and immune cell modulation. In this article, we discuss the role of neuroinflammation in the emergence of depression, namely dynamic alterations in the status of microglia response to stimulation, and how their activation phenotypes may have an etiological role in neurodegeneneration, in particular in depressive-like behavior. We will overview the involvement of miRNAs, exosomes, ectosomes and microglia in regulating critical pathways associated with depression and how they may contribute to other brain disorders including amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson disease, which share several neuroinflammatory-associated processes. Specific reference will be made to EVs as potential biomarkers and disease monitoring approaches, focusing on their potentialities as drug delivery vehicles and on putative therapeutic strategies using autologous exosome-based delivery systems to treat neurodegenerative and psychiatric disorders.

410 citations


Authors

Showing all 19716 results

NameH-indexPapersCitations
Joao Seixas1531538115070
A. Gomes1501862113951
Marco Costa1461458105096
António Amorim136147796519
Osamu Jinnouchi13588586104
P. Verdier133111183862
Andy Haas132109687742
Wendy Taylor131125289457
Steve McMahon13087878763
Timothy Andeen129106977593
Heather Gray12996680970
Filipe Veloso12888775496
Nuno Filipe Castro12896076945
Oliver Stelzer-Chilton128114179154
Isabel Marian Trigger12897477594
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023247
2022827
20214,520
20204,517
20193,810
20183,617