University of Lisbon

About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.

To be or not to be in the nucleolus

Abstract: Compartmentalization has long been known to have a key role in regulation of cellular processes. By keeping enzymes and regulatory complexes in compartments where the delivery of substrate or exit of product is controlled, competing reactions can occur simultaneously in different parts of the cell. Moreover, spatial confinement facilitates the working of molecules participating in reaction chains and is crucial for coupling unfavourable with energetically favourable chemical reactions. Although in many cases intracellular compartmentalization relies on boundaries imposed by membranes, several non-membrane-bounded compartments exist in eukaryotic cells. One of these, the nucleolus, has recently attracted much attention. The emerging view is that molecular confinement in the nucleolus actively contributes to the control of cellular survival and proliferation.

One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke.

Abstract: BackgroundPrevious studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke. The TIAregistry.org project was designed to describe the contemporary profile, etiologic factors, and outcomes in patients with a TIA or minor ischemic stroke who receive care in health systems that now offer urgent evaluation by stroke specialists. MethodsWe recruited patients who had had a TIA or minor stroke within the previous 7 days. Sites were selected if they had systems dedicated to urgent evaluation of patients with TIA. We estimated the 1-year risk of stroke and of the composite outcome of stroke, an acute coronary syndrome, or death from cardiovascular causes. We also examined the association of the ABCD2 score for the risk of stroke (range, 0 [lowest risk] to 7 [highest risk]), findings on brain imaging, and cause of TIA or minor stroke with the risk of recurrent stroke over a ...

Wind Integration in Power Systems: Operational Challenges and Possible Solutions

Abstract: This paper surveys major technical challenges for power system operations in support of large-scale wind energy integration. The fundamental difficulties of integrating wind power arise from its high inter-temporal variation and limited predictability. The impact of wind power integration is manifested in, but not limited to, scheduling, frequency regulations, and system stabilization requirements. Possible alternatives are suggested for a more reliable and cost-effective power system operation. New computationally efficient methods for improving system performances by using prediction and operational interdependencies over different time horizons remain critical open research problems.

Cell-penetrating peptides and antimicrobial peptides: how different are they?

Abstract: Some cationic peptides, referred to as CPPs (cell-penetrating peptides), have the ability to translocate across biological membranes in a non-disruptive way and to overcome the impermeable nature of the cell membrane. They have been successfully used for drug delivery into mammalian cells; however, there is no consensus about the mechanism of cellular uptake. Both endocytic and non-endocytic pathways are supported by experimental evidence. The observation that some AMPs (antimicrobial peptides) can enter host cells without damaging their cytoplasmic membrane, as well as kill pathogenic agents, has also attracted attention. The capacity to translocate across the cell membrane has been reported for some of these AMPs. Like CPPs, AMPs are short and cationic sequences with a high affinity for membranes. Similarities between CPPs and AMPs prompted us to question if these two classes of peptides really belong to unrelated families. In this Review, a critical comparison of the mechanisms that underlie cellular uptake is undertaken. A reflection and a new perspective about CPPs and AMPs are presented.

Conflict-Driven clause learning SAT solvers

Abstract: A method and apparatus for managing power consumption in a computer system wherein the method and apparatus is compliant with the proposed Advanced Configuration and Power Interface (ACPI) specification. In one embodiment, a power management processor is sandwiched between platform hardware and the ACPI register layer. The processor processes all operating power management commands and requests while remaining transparent to the user and the operating system. In so doing, routine power management functions, so classified by the operating system, are implemented by the operating system. Sophisticated power management features, on the other hand, are implemented by the present invention independent from operating system control. Accordingly, in the present invention, the operating system need not suspend processing of other threads to process sophisticated power management procedures.