Institution
University of Lisbon
Education•Lisbon, Lisboa, Portugal•
About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & European union. The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.
Papers published on a yearly basis
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TL;DR: This review aims to bring together these multidisciplinary and interdisciplinary features of MDR cancers by deciphering the molecular mechanisms underlying anticancer drug resistance, to pave the way towards the development of novel precision medicine treatment modalities that are able to surmount distinct and well-defined mechanisms of antic cancer drug resistance.
281 citations
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TL;DR: A rationale for the multiple and complex changes promoted by ceramide is provided, highlighting the interactions between ceramides and specific lipids and/or lipid phases, and the emerging evidence for the existence of ceramide-gel like domains in cellular membranes.
280 citations
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TL;DR: In this article, the information gathered for 16 still unpublished exoplanet candidates discovered with the CORALIE echelle spectrograph mounted on the Euler Swiss telescope at La Silla Observatory is summarized.
Abstract: This paper summarizes the information gathered for 16 still unpublished exoplanet candidates discovered with the CORALIE echelle spectrograph mounted on the Euler Swiss telescope at La Silla Observatory. Amongst these new candidates, 10 are typical extrasolar Jupiter-like planets on intermediate- or long-period (100 ≤ 1350 d) and fairly eccentric (0.2 ≤ e ≤ 0.5) orbits (HD 19994, HD 65216, HD 92788, HD 111232, HD 114386, HD 142415, HD 147513, HD 196050, HD 216437, HD 216770). Two of these stars are in binary systems. The next 3 candidates are shorter-period planets (HD 6434, HD 121504) with lower eccentricities among which we find a hot Jupiter (HD 83443). More interesting cases are given by the multiple-planet systems HD 82943 and HD 169830. The former is a resonant = 2/1 system in which planet-planet interactions are influencing the system evolution. The latter is more hierarchically structured.
280 citations
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University of California, Berkeley1, Princeton University2, Pontifical Catholic University of Chile3, University of Toronto4, University of Lisbon5, Academy of Athens6, University of Pennsylvania7, University of Oxford8, National Institute of Standards and Technology9, University of British Columbia10, University of Miami11, Rutgers University12, University of Pittsburgh13, Johns Hopkins University14, University of KwaZulu-Natal15, Stanford University16, West Chester University of Pennsylvania17, Goddard Space Flight Center18
TL;DR: The first detection of the gravitational lensing of the cosmic microwave background is reported through a measurement of the four-point correlation function in the temperature maps made by the Atacama Cosmology Telescope.
Abstract: We report the first detection of the gravitational lensing of the cosmic microwave background through a measurement of the four-point correlation function in the temperature maps made by the Atacama Cosmology Telescope. We verify our detection by calculating the levels of potential contaminants and performing a number of null tests. The resulting convergence power spectrum at 2° angular scales measures the amplitude of matter density fluctuations on comoving length scales of around 100 Mpc at redshifts around 0.5 to 3. The measured amplitude of the signal agrees with Lambda cold dark matter cosmology predictions. Since the amplitude of the convergence power spectrum scales as the square of the amplitude of the density fluctuations, the 4σ detection of the lensing signal measures the amplitude of density fluctuations to 12%.
280 citations
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Maastricht University1, Heidelberg University2, University of Erlangen-Nuremberg3, University of Göttingen4, University of Bonn5, Charité6, University of Genoa7, University of Geneva8, University of Cologne9, Aix-Marseille University10, VU University Amsterdam11, King's College London12, University of Eastern Finland13, Medical University of Łódź14, University of Perugia15, Aristotle University of Thessaloniki16, French Institute of Health and Medical Research17, University of Oxford18, University of Brescia19, University of Liège20, University of Gothenburg21, University of Lisbon22, University of Coimbra23, University of Antwerp24, Karolinska University Hospital25, Lund University26, Pierre-and-Marie-Curie University27, VU University Medical Center28
TL;DR: The use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage and the use of both amyloid and neuronal injury markers as proposed by the National Institute of Ageing-Alzheimer Association criteria offers the most accurate prognosis are supported.
Abstract: Three sets of research criteria are available for diagnosis of Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, International Working Group-2, and National Institute of Aging-Alzheimer Association criteria. We compared the prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage according to these criteria. Subjects with mild cognitive impairment (n = 1607), 766 of whom had both amyloid and neuronal injury markers, were recruited from 13 cohorts. We used cognitive test performance and available biomarkers to classify subjects as prodromal Alzheimer's disease according to International Working Group-1 and International Working Group-2 criteria and in the high Alzheimer's disease likelihood group, conflicting biomarker groups (isolated amyloid pathology or suspected non-Alzheimer pathophysiology), and low Alzheimer's disease likelihood group according to the National Institute of Ageing-Alzheimer Association criteria. Outcome measures were the proportion of subjects with Alzheimer's disease at the mild cognitive impairment stage and progression to Alzheimer's disease-type dementia. We performed survival analyses using Cox proportional hazards models. According to the International Working Group-1 criteria, 850 (53%) subjects had prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 50% compared to 21% for subjects without prodromal Alzheimer's disease. According to the International Working Group-2 criteria, 308 (40%) subjects had prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 61% compared to 22% for subjects without prodromal Alzheimer's disease. According to the National Institute of Ageing-Alzheimer Association criteria, 353 (46%) subjects were in the high Alzheimer's disease likelihood group, 49 (6%) in the isolated amyloid pathology group, 220 (29%) in the suspected non-Alzheimer pathophysiology group, and 144 (19%) in the low Alzheimer's disease likelihood group. The 3-year progression rate to Alzheimer's disease-type dementia was 59% in the high Alzheimer's disease likelihood group, 22% in the isolated amyloid pathology group, 24% in the suspected non-Alzheimer pathophysiology group, and 5% in the low Alzheimer's disease likelihood group. Our findings support the use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage. In clinical settings, the use of both amyloid and neuronal injury markers as proposed by the National Institute of Ageing-Alzheimer Association criteria offers the most accurate prognosis. For clinical trials, selection of subjects in the National Institute of Ageing-Alzheimer Association high Alzheimer's disease likelihood group or the International Working Group-2 prodromal Alzheimer's disease group could be considered.
279 citations
Authors
Showing all 19716 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joao Seixas | 153 | 1538 | 115070 |
A. Gomes | 150 | 1862 | 113951 |
Marco Costa | 146 | 1458 | 105096 |
António Amorim | 136 | 1477 | 96519 |
Osamu Jinnouchi | 135 | 885 | 86104 |
P. Verdier | 133 | 1111 | 83862 |
Andy Haas | 132 | 1096 | 87742 |
Wendy Taylor | 131 | 1252 | 89457 |
Steve McMahon | 130 | 878 | 78763 |
Timothy Andeen | 129 | 1069 | 77593 |
Heather Gray | 129 | 966 | 80970 |
Filipe Veloso | 128 | 887 | 75496 |
Nuno Filipe Castro | 128 | 960 | 76945 |
Oliver Stelzer-Chilton | 128 | 1141 | 79154 |
Isabel Marian Trigger | 128 | 974 | 77594 |