University of Lisbon

About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.

Immune-mediated approaches against COVID-19.

Abstract: The coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The long incubation period of this new virus, which is mostly asymptomatic yet contagious, is a key reason for its rapid spread across the world. Currently, there is no worldwide-approved treatment for COVID-19. Therefore, the clinical and scientific communities have joint efforts to reduce the severe impact of the outbreak. Research on previous emerging infectious diseases have created valuable knowledge that is being exploited for drug repurposing and accelerated vaccine development. Nevertheless, it is important to generate knowledge on SARS-CoV-2 mechanisms of infection and its impact on host immunity, to guide the design of COVID-19 specific therapeutics and vaccines suitable for mass immunization. Nanoscale delivery systems are expected to play a paramount role in the success of these prophylactic and therapeutic approaches. This Review provides an overview of SARS-CoV-2 pathogenesis and examines immune-mediated approaches currently explored for COVID-19 treatments, with an emphasis on nanotechnological tools.

Geoconservation as an Emerging Geoscience

Abstract: The main purpose of geoconservation is the conservation of geosites as basic units of the geological heritage through the implementation of specific inventory, evaluation, conservation, valuation and monitoring procedures. In this paper, geoconservation is characterised as an emergent geoscience within the Earth and Space Sciences where its scope and methods, as well as production and validation of knowledge can be recognised–thus defining Basic Geoconservation–, interrelations with other earth sciences can be established–thus supporting Applied Geoconservation–, and Technical Applications of Geoconservation can be identified through the production of materials, methods and/or scientific services useful to society, namely geoeducation. Promoting scientific education relevant to sustainable development requires new educational approaches involving the Earth Sciences, namely through geoconservation, in order to provide citizens with tools to face environmental problems, such as those arising from the depletion of geological resources—which seriously threaten the geological heritage of the Earth—and the information, skills and will make forward-looking choices, like supporting the legal protection of Natural Monuments and/or the implementation of geotourism (including geoparks).

Alpha-synuclein: from secretion to dysfunction and death

Abstract: The aggregation, deposition, and dysfunction of alpha-synuclein (aSyn) are common events in neurodegenerative disorders known as synucleinopathies. These include Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. A growing body of knowledge on the biology of aSyn is emerging and enabling novel hypotheses to be tested. In particular, the hypothesis that aSyn is secreted from neurons, thus contributing to the spreading of pathology not only in the brain but also in other organs, is gaining momentum. Nevertheless, the precise mechanism(s) of secretion, as well as the consequences of extracellular aSyn species for neighboring cells are still unclear. Here, we review the current literature and integrate existing data in order to propose possible mechanisms of secretion, cell dysfunction, and death. Ultimately, the complete understanding of these processes might open novel avenues for the development of new therapeutic strategies.