University of Ljubljana

About: University of Ljubljana is a education organization based out in Ljubljana, Slovenia. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 17210 authors who have published 47013 publications receiving 1082684 citations. The organization is also known as: Univerza v Ljubljani.

Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Abstract: Organ injury and impairment are commonly observed in patients with acute heart failure (AHF), and congestion is an essential pathophysiological mechanism of impaired organ function Congestion is the predominant clinical profile in most patients with AHF; a smaller proportion presents with peripheral hypoperfusion or cardiogenic shock Hypoperfusion further deteriorates organ function The injury and dysfunction of target organs (ie heart, lungs, kidneys, liver, intestine, brain) in the setting of AHF are associated with increased risk for mortality Improvement in organ function after decongestive therapies has been associated with a lower risk for post-discharge mortality Thus, the prevention and correction of organ dysfunction represent a therapeutic target of interest in AHF and should be evaluated in clinical trials Treatment strategies that specifically prevent, reduce or reverse organ dysfunction remain to be identified and evaluated to determine if such interventions impact mortality, morbidity and patient-centred outcomes This paper reflects current understanding among experts of the presentation and management of organ impairment in AHF and suggests priorities for future research to advance the field

General minimal flavor violation

Abstract: A model independent study of the minimal flavor violation (MFV) framework is presented, where the only sources of flavor breaking at low energy are the up and down Yukawa matrices. Two limits are identified for the Yukawa coupling expansion: linear MFV, where it is truncated at the leading terms, and nonlinear MFV, where such a truncation is not possible due to large third generation Yukawa couplings. These are then resummed to all orders using nonlinear $\ensuremath{\sigma}$-model techniques familiar from models of collective breaking. Generically, flavor-diagonal $CP$ violating (CPV) sources in the UV can induce $O(1)$ CPV in processes involving third generation quarks. Because of a residual $U(2)$ symmetry, the extra CPV in ${B}_{d}\ensuremath{-}{\overline{B}}_{d}$ mixing is bounded by CPV in ${B}_{s}\ensuremath{-}{\overline{B}}_{s}$ mixing. If operators with right-handed light quarks are subdominant, the extra CPV is equal in the two systems, and is negligible in processes involving only the first two generations. We find large enhancements in the up-type sector, both in CPV in $D\ensuremath{-}\overline{D}$ mixing and in top flavor violation.