Institution
University of Ljubljana
Education•Ljubljana, Slovenia•
About: University of Ljubljana is a education organization based out in Ljubljana, Slovenia. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 17210 authors who have published 47013 publications receiving 1082684 citations. The organization is also known as: Univerza v Ljubljani.
Papers published on a yearly basis
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German Cancer Research Center1, University of Barcelona2, National University of Colombia3, Manchester Royal Infirmary4, Charles University in Prague5, University of Ljubljana6, Universidad Nacional de Asunción7, University of Birmingham8, Université de Montréal9, Pompeu Fabra University10, Mexican Social Security Institute11, Catholic University of Korea12, University of Lagos13, Bangabandhu Sheikh Mujib Medical University14, Hospital General de México15, NewYork–Presbyterian Hospital16, Gomel State Medical University17, Instituto Português de Oncologia Francisco Gentil18, University of the Philippines19, Koç University20, Hacettepe University21, Indian Council of Medical Research22, University of Hawaii23, Cedars-Sinai Medical Center24, Hospital General San Juan de Dios25, Universidad Nacional Autónoma de Honduras26, Bayero University Kano27, Central University of Venezuela28, University of Chile29, Instituto Potosino de Investigación Científica y Tecnológica30
TL;DR: This large international study to estimate fractions of head and neck cancers attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation confirms the important role ofHPVs in oropharyngeal cancer and drastically downplays the previously reported involvement of HPVs in the other HNCs.
Abstract: BACKGROUND:
We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation.
METHODS:
Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All samples were subject to histopathological evaluation, DNA quality control, and HPV-DNA detection. Samples containing HPV-DNA were further subject to HPV E6*I mRNA detection and to p16(INK4a), pRb, p53, and Cyclin D1 immunohistochemistry. Final estimates of HPV-AFs were based on HPV-DNA, HPV E6*I mRNA, and/or p16(INK4a) results.
RESULTS:
A total of 3680 samples yielded valid results: 1374 pharyngeal, 1264 OC, and 1042 laryngeal cancers. HPV-AF estimates based on positivity for HPV-DNA, and for either HPV E6*I mRNA or p16(INK4a), were 22.4%, 4.4%, and 3.5% for cancers of the oropharynx, OC, and larynx, respectively, and 18.5%, 3.0%, and 1.5% when requiring simultaneous positivity for all three markers. HPV16 was largely the most common type. Estimates of HPV-AF in the oropharynx were highest in South America, Central and Eastern Europe, and Northern Europe, and lowest in Southern Europe. Women showed higher HPV-AFs than men for cancers of the oropharynx in Europe and for the larynx in Central-South America.
CONCLUSIONS:
HPV contribution to HNCs is substantial but highly heterogeneous by cancer site, region, and sex. This study, the largest exploring HPV attribution in HNCs, confirms the important role of HPVs in oropharyngeal cancer and drastically downplays the previously reported involvement of HPVs in the other HNCs.
548 citations
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TL;DR: In this article, social exchange theory is used to understand the negative consequences of knowledge hiding on the creativity of a knowledge hider, which may prevent colleagues from generating creative ideas, but it may also have negative consequences for the knowledge hiding itself.
Abstract: Knowledge hiding prevents colleagues from generating creative ideas, but it may also have negative consequences for the creativity of a knowledge hider. Drawing on social exchange theory, we propos...
528 citations
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TL;DR: Solid-phase microextraction (SPME) as mentioned in this paper is a sample preparation technique that minimizes the consumption of organic solvents and has been shown to be useful in analytical chemistry.
Abstract: In recent years, much attention in analytical chemistry has been paid to sample preparation techniques, especially those which minimise the consumption of organic solvents One of the most promising of these, solid-phase microextraction (SPME), is presented in both its theoretical and practical aspects Conditions which affect its performance are assessed, as are the problems which may arise from its use Finally, some typical applications are listed, highlighting the method's sensitivity and precision, and the range of samples where SPME can be used successfully
526 citations
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Pennsylvania State University1, Special Astrophysical Observatory2, University of Hertfordshire3, Purple Mountain Observatory4, Brera Astronomical Observatory5, University College London6, Liverpool John Moores University7, Goddard Space Flight Center8, University of Leicester9, University of Warsaw10, University of Nevada, Las Vegas11, Universities Space Research Association12, University of Milan13, University of Amsterdam14, Marshall Space Flight Center15, Hebrew University of Jerusalem16, University of Bologna17, Spanish National Research Council18, European Southern Observatory19, Space Telescope Science Institute20, Leiden University21, Swinburne University of Technology22, ASTRON23, University of Ljubljana24, Warsaw University of Technology25, INAF26, University of Warwick27, Aryabhatta Research Institute of Observational Sciences28, Joint Institute for VLBI in Europe29, University of California, Santa Cruz30, University of Perugia31
TL;DR: Observations of the extraordinarily bright prompt optical and γ-ray emission of GRB 080319B that provide diagnostics within seconds of its formation, followed by broadband observations of the afterglow decay that continued for weeks.
Abstract: Long-duration gamma-ray bursts (GRBs) release copious amounts of energy across the entire electromagnetic spectrum, and so provide a window into the process of black hole formation from the collapse of massive stars Previous early optical observations of even the most exceptional GRBs (990123 and 030329) lacked both the temporal resolution to probe the optical flash in detail and the accuracy needed to trace the transition from the prompt emission within the outflow to external shocks caused by interaction with the progenitor environment Here we report observations of the extraordinarily bright prompt optical and gamma-ray emission of GRB 080319B that provide diagnostics within seconds of its formation, followed by broadband observations of the afterglow decay that continued for weeks We show that the prompt emission stems from a single physical region, implying an extremely relativistic outflow that propagates within the narrow inner core of a two-component jet
524 citations
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TL;DR: It is recognised that the key drivers of this epidemic form an obesogenic environment, which includes changing food systems and reduced physical activity, and there is a need to implement effective programmes and policies in multiple sectors to address overnutrition, undernutrition, mobility and physical activity.
Abstract: In recent decades, the prevalence of obesity in children has increased dramatically. This worldwide epidemic has important consequences, including psychiatric, psychological and psychosocial disorders in childhood and increased risk of developing non-communicable diseases (NCDs) later in life. Treatment of obesity is difficult and children with excess weight are likely to become adults with obesity. These trends have led member states of the World Health Organization (WHO) to endorse a target of no increase in obesity in childhood by 2025. Estimates of overweight in children aged under 5 years are available jointly from the United Nations Children’s Fund (UNICEF), WHO and the World Bank. The Institute for Health Metrics and Evaluation (IHME) has published country-level estimates of obesity in children aged 2–4 years. For children aged 5–19 years, obesity estimates are available from the NCD Risk Factor Collaboration. The global prevalence of overweight in children aged 5 years or under has increased modestly, but with heterogeneous trends in low and middle-income regions, while the prevalence of obesity in children aged 2–4 years has increased moderately. In 1975, obesity in children aged 5–19 years was relatively rare, but was much more common in 2016. It is recognised that the key drivers of this epidemic form an obesogenic environment, which includes changing food systems and reduced physical activity. Although cost-effective interventions such as WHO ‘best buys’ have been identified, political will and implementation have so far been limited. There is therefore a need to implement effective programmes and policies in multiple sectors to address overnutrition, undernutrition, mobility and physical activity. To be successful, the obesity epidemic must be a political priority, with these issues addressed both locally and globally. Work by governments, civil society, private corporations and other key stakeholders must be coordinated.
524 citations
Authors
Showing all 17388 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Miller | 203 | 2573 | 204840 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
James M. Tour | 143 | 859 | 91364 |
Carmen García | 139 | 1503 | 96925 |
Bernt Schiele | 130 | 568 | 70032 |
Vladimir Cindro | 129 | 1157 | 82000 |
Teresa Barillari | 129 | 984 | 78782 |
Sven Menke | 129 | 1121 | 82034 |
Horst Oberlack | 129 | 985 | 80069 |
Hubert Kroha | 129 | 1126 | 80746 |
Peter Schacht | 129 | 1030 | 80092 |
Siegfried Bethke | 129 | 1266 | 103520 |
Igor Mandić | 128 | 1065 | 79498 |
Stefan Kluth | 128 | 1261 | 84534 |
Andrej Gorišek | 128 | 951 | 67830 |