Institution
University of Ljubljana
Education•Ljubljana, Slovenia•
About: University of Ljubljana is a education organization based out in Ljubljana, Slovenia. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 17210 authors who have published 47013 publications receiving 1082684 citations. The organization is also known as: Univerza v Ljubljani.
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TL;DR: Individual-nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) data show that hnRNP C recognizes uridine tracts with a defined long-range spacing consistent with hmRNP particle organization, and integration of transcriptome-wide iCLIP data and alternative splicing profiles into an 'RNA map' indicates how the positioning of hn RNP particles determines their effect on the inclusion of alternative exons.
Abstract: In the nucleus of eukaryotic cells, nascent transcripts are associated with heterogeneous nuclear ribonucleoprotein (hnRNP) particles that are nucleated by hnRNP C. Despite their abundance, however, it remained unclear whether these particles control pre-mRNA processing. Here, we developed individual-nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) to study the role of hnRNP C in splicing regulation. iCLIP data show that hnRNP C recognizes uridine tracts with a defined long-range spacing consistent with hnRNP particle organization. hnRNP particles assemble on both introns and exons but remain generally excluded from splice sites. Integration of transcriptome-wide iCLIP data and alternative splicing profiles into an 'RNA map' indicates how the positioning of hnRNP particles determines their effect on the inclusion of alternative exons. The ability of high-resolution iCLIP data to provide insights into the mechanism of this regulation holds promise for studies of other higher-order ribonucleoprotein complexes.
1,053 citations
01 Jan 1993
TL;DR: In the paper an introduction to main social networks centrality measures is given, a new view on these measures is proposed, based on relational algebra, which is implemented in computer programs CENTRAL and FLOWIND.
Abstract: In the paper an introduction to main social networks centrality measures is given. A new view on these measures is proposed, based on relational algebra . All described measures are implemented in computer programs CENTRAL and FLOWIND.
1,044 citations
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TL;DR: A sensitivity analysis-based method for explaining prediction models that can be applied to any type of classification or regression model, and which is equivalent to commonly used additive model-specific methods when explaining an additive model.
Abstract: We present a sensitivity analysis-based method for explaining prediction models that can be applied to any type of classification or regression model. Its advantage over existing general methods is that all subsets of input features are perturbed, so interactions and redundancies between features are taken into account. Furthermore, when explaining an additive model, the method is equivalent to commonly used additive model-specific methods. We illustrate the method's usefulness with examples from artificial and real-world data sets and an empirical analysis of running times. Results from a controlled experiment with 122 participants suggest that the method's explanations improved the participants' understanding of the model.
1,024 citations
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University of Basel1, Radboud University Nijmegen2, University of Padua3, Complutense University of Madrid4, University of Paris5, University of Zurich6, University of Bari7, Lithuanian University of Health Sciences8, University of Florence9, Russian Academy10, Rambam Health Care Campus11, University of Regensburg12, Charité13, University of the Witwatersrand14, Johns Hopkins University15, University of Coimbra16, University of Verona17, Lund University18, University of Ljubljana19, Utrecht University20, University of Pécs21, Medical University of Vienna22, University of Debrecen23, Sapienza University of Rome24, University of Geneva25, University of Silesia in Katowice26, University College London27, University of Tübingen28, Military Medical Academy29, Lille University of Science and Technology30, University of Michigan31, Iuliu Hațieganu University of Medicine and Pharmacy32, Charles University in Prague33, University of Zagreb34
TL;DR: Disease-related causes, in particular pulmonary fibrosis, PAH and cardiac causes, accounted for the majority of deaths in SSc.
Abstract: Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc). Methods Patients with SSc (n=5860) fulfilling the American College of Rheumatology criteria and prospectively followed in the EULAR Scleroderma Trials and Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause of death and comorbidities. Kaplan-Meier and Cox proportional hazards models were used to analyse survival in SSc subgroups and to identify predictors of mortality. Results Questionnaires were obtained on 234 of 284 fatalities. 55% of deaths were attributed directly to SSc and 41% to non-SSc causes; in 4% the cause of death was not assigned. Of the SSc-related deaths, 35% were attributed to pulmonary fibrosis, 26% to pulmonary arterial hypertension (PAH) and 26% to cardiac causes (mainly heart failure and arrhythmias). Among the non-SSc-related causes, infections (33%) and malignancies (31%) were followed by cardiovascular causes (29%). Of the non-SSc-related fatalities, 25% died of causes in which SSc-related complications may have participated (pneumonia, sepsis and gastrointestinal haemorrhage). Independent risk factors for mortality and their HR were: proteinuria (HR 3.34), the presence of PAH based on echocardiography (HR 2.02), pulmonary restriction (forced vital capacity below 80% of normal, HR 1.64), dyspnoea above New York Heart Association class II (HR 1.61), diffusing capacity of the lung (HR 1.20 per 10% decrease), patient age at onset of Raynaud's phenomenon (HR 1.30 per 10 years) and the modified Rodnan skin score (HR 1.20 per 10 score points). Conclusion Disease-related causes, in particular pulmonary fibrosis, PAH and cardiac causes, accounted for the majority of deaths in SSc.
1,010 citations
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TL;DR: A conceptual model that combines unified theory of acceptance and use of technology (UTAUT) with perceived risk with respect to usage behaviour of Internet banking is developed and some relationships of UTAUT are supported.
1,010 citations
Authors
Showing all 17388 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Miller | 203 | 2573 | 204840 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
James M. Tour | 143 | 859 | 91364 |
Carmen García | 139 | 1503 | 96925 |
Bernt Schiele | 130 | 568 | 70032 |
Vladimir Cindro | 129 | 1157 | 82000 |
Teresa Barillari | 129 | 984 | 78782 |
Sven Menke | 129 | 1121 | 82034 |
Horst Oberlack | 129 | 985 | 80069 |
Hubert Kroha | 129 | 1126 | 80746 |
Peter Schacht | 129 | 1030 | 80092 |
Siegfried Bethke | 129 | 1266 | 103520 |
Igor Mandić | 128 | 1065 | 79498 |
Stefan Kluth | 128 | 1261 | 84534 |
Andrej Gorišek | 128 | 951 | 67830 |