University of Lorraine

About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.

The importance of gene–environment interactions in human obesity

Abstract: The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However, who becomes obese in an obesity-prone environment is largely determined by genetic factors. In the last 20 years, important progress has been made in the elucidation of the genetic architecture of obesity. In parallel with successful gene identifications, the number of gene–environment interaction (GEI) studies has grown rapidly. This paper reviews the growing body of evidence supporting gene–environment interactions in the field of obesity. Heritability, monogenic and polygenic obesity studies provide converging evidence that obesity-predisposing genes interact with a variety of environmental, lifestyle and treatment exposures. However, some skepticism remains regarding the validity of these studies based on several issues, which include statistical modelling, confounding, low replication rate, underpowered analyses, biological assumptions and measurement precision. What follows in this review includes (1) an introduction to the study of GEI, (2) the evidence of GEI in the field of obesity, (3) an outline of the biological mechanisms that may explain these interaction effects, (4) methodological challenges associated with GEI studies and potential solutions, and (5) future directions of GEI research. Thus far, this growing body of evidence has provided a deeper understanding of GEI influencing obesity and may have tremendous applications in the emerging field of personalized medicine and individualized lifestyle recommendations.

Quantum Generalized Hydrodynamics

Abstract: Physical systems made of many interacting quantum particles can often be described by Euler hydrodynamic equations in the limit of long wavelengths and low frequencies. Recently such a classical hydrodynamic framework, now dubbed generalized hydrodynamics (GHD), was found for quantum integrable models in one spatial dimension. Despite its great predictive power, GHD, like any Euler hydrodynamic equation, misses important quantum effects, such as quantum fluctuations leading to nonzero equal-time correlations between fluid cells at different positions. Focusing on the one-dimensional gas of bosons with delta repulsion, and on states of zero entropy, for which quantum fluctuations are larger, we reconstruct such quantum effects by quantizing GHD. The resulting theory of quantum GHD can be viewed as a multicomponent Luttinger liquid theory, with a small set of effective parameters that are fixed by the thermodynamic Bethe ansatz. It describes quantum fluctuations of truly nonequilibrium systems where conventional Luttinger liquid theory fails.

General Active Global Stabilization of Multiloads DC-Power Networks

Abstract: Implantation of complex dc-power network is one of the main research topics in more electric aircraft (MEA). In such applications, small and light systems are required and so optimization of passive elements, such as dc-bus capacitance and filtering inductance, is an important issue. It is known that the reduction of dc-bus capacitance may lead to instability of an MVdc network. So, if no stabilizer is used, the risk of instability must be considered, while designing the system passive elements. In this paper, we will first study the small signal stability of an MVdc network composed of three loads: an inverter supplying a permanent magnet synchronous motor, a dc/dc converter feeding a resistive load, and a supercapacitor controlled by a bidirectional dc/dc converter. Then, we will propose a large-signal-stabilizing system to ensure global stability by generating proper stabilizing power references for the whole system. The contribution of the loads to network stability is adjustable. The validity of the proposed method will be confirmed by experimentations.

Creation of Magnetic Skyrmion Bubble Lattices by Ultrafast Laser in Ultrathin Films.

Abstract: Magnetic skyrmions are topologically nontrivial spin textures which hold great promise as stable information carriers in spintronic devices at the nanoscale. One of the major challenges for developing novel skyrmion-based memory and logic devices is fast and controlled creation of magnetic skyrmions at ambient conditions. Here we demonstrate controlled generation of skyrmion bubbles and skyrmion bubble lattices from a ferromagnetic state in sputtered ultrathin magnetic films at room temperature by a single ultrafast (35 fs) laser pulse. The skyrmion bubble density increases with the laser fluence, and it finally becomes saturated, forming disordered hexagonal lattices. Moreover, we present that the skyrmion bubble lattice configuration leads to enhanced topological stability as compared to isolated skyrmions, suggesting its promising use in data storage. Our findings shed light on the optical approach to the skyrmion bubble lattice in commonly accessible materials, paving the road toward the emerging skyrmion-based memory and synaptic devices.