Institution
University of Lorraine
Education•Nancy, France•
About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors performed a Sobol' global sensitivity analysis of the Noah land surface model with multiple process options (Noah-MP) and identified 139 hard-coded parameters in the model code.
Abstract: Land surface models incorporate a large number of process descriptions, containing a multitude of parameters. These parameters are typically read from tabulated input files. Some of these parameters might be fixed numbers in the computer code though, which hinder model agility during calibration. Here we identified 139 hard-coded parameters in the model code of the Noah land surface model with multiple process options (Noah-MP). We performed a Sobol' global sensitivity analysis of Noah-MP for a specific set of process options, which includes 42 out of the 71 standard parameters and 75 out of the 139 hard-coded parameters. The sensitivities of the hydrologic output fluxes latent heat and total runoff as well as their component fluxes were evaluated at 12 catchments within the United States with very different hydrometeorological regimes. Noah-MP's hydrologic output fluxes are sensitive to two thirds of its applicable standard parameters (i.e., Sobol' indexes above 1%). The most sensitive parameter is, however, a hard-coded value in the formulation of soil surface resistance for direct evaporation, which proved to be oversensitive in other land surface models as well. Surface runoff is sensitive to almost all hard-coded parameters of the snow processes and the meteorological inputs. These parameter sensitivities diminish in total runoff. Assessing these parameters in model calibration would require detailed snow observations or the calculation of hydrologic signatures of the runoff data. Latent heat and total runoff exhibit very similar sensitivities because of their tight coupling via the water balance. A calibration of Noah-MP against either of these fluxes should therefore give comparable results. Moreover, these fluxes are sensitive to both plant and soil parameters. Calibrating, for example, only soil parameters hence limit the ability to derive realistic model parameters. It is thus recommended to include the most sensitive hard-coded model parameters that were exposed in this study when calibrating Noah-MP.
95 citations
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TL;DR: BAT was safe and significantly improved QOL, 6MHW, and NT-proBNP and the major adverse neurological or cardiovascular system or procedure-related event rate (MANCE).
95 citations
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TL;DR: Organic Compounds David Tilly,† Floris Chevallier,† Florence Mongin,*,† and Philippe C. Gros*,‡.
Abstract: Organic Compounds David Tilly,† Floris Chevallier,† Florence Mongin,*,† and Philippe C. Gros*,‡,§ †Equipe Chimie et Photonique Molećulaires, Institut des Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite ́ de Rennes 1, Bat̂iment 10A, Case 1003, Campus de Beaulieu, Avenue du Geńeŕal Leclerc, 35042 Rennes Ced́ex, France ‡HECRIN, Universite ́ de Lorraine, SRSMC UMR 7565, Boulevard des Aiguillettes, 54506 Vandoeuvre-les̀-Nancy, France HECRIN, CNRS, SRSMC UMR 7565, Boulevard des Aiguillettes, 54506 Vandoeuvre-les̀-Nancy, France
95 citations
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TL;DR: A genomic and phylogenetic analysis of Cys-GSTs in photosynthetic organisms provides an updated classification and connection of GSTs with secondary metabolism may be interesting from a pharmacological perspective.
Abstract: Glutathione transferases (GSTs) represent a widespread multigenic enzyme family able to modify a broad range of molecules. These notably include secondary metabolites and exogenous substrates often ...
95 citations
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TL;DR: In this paper, the authors identify and better understand the factors that trigger and maintain the myocardial fibrotic response against different injuries in a variety of cardiac diseases, such as arrhythmias, and ischaemia, and thereby determine the clinical course and outcome of cardiac patients even when adequately treated.
Abstract: Myocardial fibrosis is the result of excessive fibrillar collagen synthesis and deposition without reciprocally balanced degradation. It causes cardiac dysfunction, arrhythmias, and ischaemia, and thereby determines the clinical course and outcome of cardiac patients even when adequately treated. Therefore, further research is needed to identify and better understand the factors that trigger and maintain the myocardial fibrotic response against different injuries in a variety of cardiac diseases. Here, we will focus on the following major areas of research: molecules that stimulate the differentiation of fibroblasts into myofibroblasts and subsequently alter collagen turnover (e.g. cardiotrophin-1, galectin-3, NADPH oxidases, and neutrophil gelatinase-associated lipocalin), microRNA-induced alterations of collagen gene expression, and matricellular protein- and lysyl oxidase-mediated alterations of collagen cross-linking and deposition.
95 citations
Authors
Showing all 12161 results
Name | H-index | Papers | Citations |
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Jonathan I. Epstein | 138 | 1121 | 80975 |
Peter Tugwell | 129 | 948 | 125480 |
David Brown | 105 | 1257 | 46827 |
Faiez Zannad | 103 | 839 | 90737 |
Sabu Thomas | 102 | 1554 | 51366 |
Francis Martin | 98 | 733 | 43991 |
João F. Mano | 97 | 822 | 36401 |
Jonathan A. Epstein | 94 | 299 | 27492 |
Muhammad Imran | 94 | 3053 | 51728 |
Laurent Peyrin-Biroulet | 90 | 901 | 34120 |
Athanase Benetos | 83 | 391 | 31718 |
Michel Marre | 82 | 444 | 39052 |
Bruno Rossion | 80 | 337 | 21902 |
Lyn March | 78 | 367 | 62536 |
Alan J. M. Baker | 76 | 234 | 26080 |