Institution
University of Lorraine
Education•Nancy, France•
About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.
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University of Glasgow1, Golden Jubilee National Hospital2, Harvard University3, Mario Negri Institute for Pharmacological Research4, Imperial College London5, Glasgow Royal Infirmary6, Duke University7, University of Oslo8, University of Copenhagen9, University of Michigan10, University of Gothenburg11, University of Lorraine12, Medical University of South Carolina13
TL;DR: Rates of sudden death declined substantially over time among ambulatory patients with heart failure with reduced ejection fraction who were enrolled in clinical trials, a finding that is consistent with a cumulative benefit of evidence‐based medications on this cause of death.
Abstract: BackgroundThe risk of sudden death has changed over time among patients with symptomatic heart failure and reduced ejection fraction with the sequential introduction of medications including angiotensin-converting–enzyme inhibitors, angiotensin-receptor blockers, beta-blockers, and mineralocorticoid-receptor antagonists. We sought to examine this trend in detail. MethodsWe analyzed data from 40,195 patients who had heart failure with reduced ejection fraction and were enrolled in any of 12 clinical trials spanning the period from 1995 through 2014. Patients who had an implantable cardioverter–defibrillator at the time of trial enrollment were excluded. Weighted multivariable regression was used to examine trends in rates of sudden death over time. Adjusted hazard ratios for sudden death in each trial group were calculated with the use of Cox regression models. The cumulative incidence rates of sudden death were assessed at different time points after randomization and according to the length of time betwe...
325 citations
TL;DR: TPCs make up an ion channel family that couples the cell's metabolic state to endolysosomal function and are crucial for physical endurance during food restriction and Mutant mice lacking lysoNa(ATP) have much reduced exercise endurance after fasting.
324 citations
TL;DR: The anticipated aggregate treatment effects of early comprehensive disease-modifying pharmacological therapy are substantial and support the combination use of an ARNI, β blocker, MRA, and SGLT2 inhibitor as a new therapeutic standard among patients with chronic HFrEF.
321 citations
TL;DR: In an umbrella review of meta-analyses of observational studies examining environmental factors and risk of inflammatory bowel diseases, varying levels of evidence for associations of different environmental factors with risk of IBD is found.
319 citations
TL;DR: In this article, a compilation of whole-rock geochemical data available in the literature is used to show that fractional crystallization alone is not sufficient to explain the distribution of Niobium/Tantalum (Nb/Ta) in most peraluminous granites.
Abstract: In their late stages of evolution, peraluminous granitic melts exsolve large amounts of fluidswhich can modify the chemical composition of granitic whole-rock samples. The niobium/tantalum (Nb/Ta) ratio is expected to decrease during the magmatic differentiation of graniticmelts, but the behavior of both elements at the magmatic-hydrothermal transition remainsunclear. Using a compilation of whole-rock geochemical data available in the literature, wedemonstrate that fractional crystallization alone is not sufficient to explain the distribution ofNb-Ta in most peraluminous granites. However, we notice that most of the granitic samplesdisplaying evidence of interactions with fluids have Nb/Ta < 5. We propose that the decreaseof the Nb/Ta ratio in evolved melts is the consequence of both fractional crystallization andsub-solidus hydrothermal alteration. We suggest that the Nb/Ta value of ~5 fingerprints themagmatic-hydrothermal transition in peraluminous granites. Furthermore, a Nb/Ta ratio of ~5appears to be a good marker to discriminate mineralized from barren peraluminous granites.
319 citations
Authors
Showing all 12161 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jonathan I. Epstein | 138 | 1121 | 80975 |
| Peter Tugwell | 129 | 948 | 125480 |
| David Brown | 105 | 1257 | 46827 |
| Faiez Zannad | 103 | 839 | 90737 |
| Sabu Thomas | 102 | 1554 | 51366 |
| Francis Martin | 98 | 733 | 43991 |
| João F. Mano | 97 | 822 | 36401 |
| Jonathan A. Epstein | 94 | 299 | 27492 |
| Muhammad Imran | 94 | 3053 | 51728 |
| Laurent Peyrin-Biroulet | 90 | 901 | 34120 |
| Athanase Benetos | 83 | 391 | 31718 |
| Michel Marre | 82 | 444 | 39052 |
| Bruno Rossion | 80 | 337 | 21902 |
| Lyn March | 78 | 367 | 62536 |
| Alan J. M. Baker | 76 | 234 | 26080 |