Institution
University of Lorraine
Education•Nancy, France•
About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.
Papers published on a yearly basis
Papers
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TL;DR: This research presents a novel and scalable approach called “Perinatal Perinatal Programming,” which aims to provide real-time information about the development of babies born with Down's syndrome through the first trimester.
Abstract: *The Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, UK; †The Fetal Medicine Unit, John Radcliffe Hospital, Oxford, UK; ‡Department of Obstetrics and Division of Experimental Obstetrics, Study Group Perinatal Programming, Charité Campus Virchow, Berlin, Germany; §Department of Obstetrics and Gynecology, General Faculty Hospital, Charles University, Prague, Czech Republic; ¶Department of Obstetrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; **Centre Hospitalier Régional Universitaire de Nancy, Université de Lorraine, Nancy, France; ††Fetomaternal Medical Center, Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; ‡‡Prenatal Zürich, Zürich, Switzerland; §§Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; ¶¶University of Liège, CHR de la Citadelle, Liège, Belgium *Correspondence. (e-mail: sally.collins@obs-gyn.ox.ac.uk)
222 citations
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Harvard University1, Novartis2, University of Minnesota3, Fudan University4, National University of Singapore5, National University of Cordoba6, Baylor University Medical Center7, Charité8, Mayo Clinic9, Université de Montréal10, University of Groningen11, University of Lorraine12, Medical University of South Carolina13, Veterans Health Administration14, University of Glasgow15
TL;DR: The PARAGON-HF trial will determine whether sacubitril/valsartan is superior to angiotensin receptor blockade alone in patients with chronic symptomatic HFpEF.
Abstract: Objectives The PARAGON-HF (Prospective Comparison of ARNI with ARB Global Outcomes in HF With Preserved Ejection Fraction) trial is designed to determine the efficacy and safety of the angiotensin receptor neprilysin inhibitor sacubitril/valsartan compared with valsartan in patients with chronic heart failure and preserved ejection fraction (HFpEF). Background HFpEF is highly prevalent, associated with substantial morbidity and mortality, and in need of effective therapies that improve outcomes. The angiotensin receptor neprilysin inhibitor (ARNI) sacubitril/valsartan, which has been shown to benefit patients with heart failure (HF) and reduced ejection fraction, demonstrated favorable physiologic effects in a phase II HFpEF trial. Methods The PARAGON-HF trial is a randomized, double-blind, parallel group, active-controlled, event-driven trial comparing the long-term efficacy and safety of valsartan and sacubitril/valsartan in patients with chronic HFpEF (left ventricular ejection fraction ≥45%), New York Heart Association functional class II to IV symptoms, elevated natriuretic peptides, and evidence of structural heart disease. Before randomization, all patients entered sequential single-blind run-in periods to ensure tolerability of both drugs at half the target doses (i.e., valsartan titrated to 80 mg bid followed by sacubitril/valsartan 49/51 mg [100 mg] bid). The primary outcome is the composite of cardiovascular death and total (first and recurrent) HF hospitalizations. Conclusions PARAGON-HF will determine whether sacubitril/valsartan is superior to angiotensin receptor blockade alone in patients with chronic symptomatic HFpEF. (Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction [PARAGON-HF]; NCT01920711)
222 citations
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TL;DR: A review of the different antimicrobial applications of copper in water treatment, hospital care units and public applications and the future research needs on copper as an antimicrobial agent are discussed.
221 citations
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TL;DR: TPC-ACs had similar performances to those of commercial ACs, and might significantly improve the economic balance of the production of pyrolysis oil from waste tyres.
221 citations
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Imperial College London1, University of Bari2, Pasteur Institute3, University of Gothenburg4, University of Washington5, Agency for Science, Technology and Research6, University of Hong Kong7, University of Ottawa8, French Institute of Health and Medical Research9, Ottawa Hospital10, King's College London11, University of East Anglia12, university of lille13, Wellcome Trust Sanger Institute14, University of Paris-Sud15, Claude Bernard University Lyon 116, University of Lorraine17, Queen Mary University of London18, National University of Singapore19, McGill University20, National Institutes of Health21
TL;DR: This study provides a first genetic link between carbohydrate metabolism and BMI and demonstrates the power of integrated genomic approaches beyond genome-wide association studies.
Abstract: Common multi-allelic copy number variants (CNVs) appear enriched for phenotypic associations compared to their biallelic counterparts. Here we investigated the influence of gene dosage effects on adiposity through a CNV association study of gene expression levels in adipose tissue. We identified significant association of a multi-allelic CNV encompassing the salivary amylase gene (AMY1) with body mass index (BMI) and obesity, and we replicated this finding in 6,200 subjects. Increased AMY1 copy number was positively associated with both amylase gene expression (P = 2.31 × 10(-14)) and serum enzyme levels (P 9) and bottom (copy number < 4) 10% of the copy number distribution. Our study provides a first genetic link between carbohydrate metabolism and BMI and demonstrates the power of integrated genomic approaches beyond genome-wide association studies.
220 citations
Authors
Showing all 12161 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jonathan I. Epstein | 138 | 1121 | 80975 |
Peter Tugwell | 129 | 948 | 125480 |
David Brown | 105 | 1257 | 46827 |
Faiez Zannad | 103 | 839 | 90737 |
Sabu Thomas | 102 | 1554 | 51366 |
Francis Martin | 98 | 733 | 43991 |
João F. Mano | 97 | 822 | 36401 |
Jonathan A. Epstein | 94 | 299 | 27492 |
Muhammad Imran | 94 | 3053 | 51728 |
Laurent Peyrin-Biroulet | 90 | 901 | 34120 |
Athanase Benetos | 83 | 391 | 31718 |
Michel Marre | 82 | 444 | 39052 |
Bruno Rossion | 80 | 337 | 21902 |
Lyn March | 78 | 367 | 62536 |
Alan J. M. Baker | 76 | 234 | 26080 |