University of Lorraine

About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.

Sustained Progression-Free Survival Benefit of Rituximab Maintenance in Patients With Follicular Lymphoma: Long-Term Results of the PRIMA Study

Abstract: PURPOSEThe PRIMA study (ClinicalTrials.gov identifier: NCT00140582) established that 2 years of rituximab maintenance after first-line immunochemotherapy significantly improved progression-free sur...

A new insight into cell walls of Chlorophyta

Abstract: Green microalgae, and Chlorophyta in particular, are considered as a renewable source of valuable chemicals for biofuel, nutraceutical or pharmaceutical industries, among others. Microalgae store most of their valuable components inside the cell behind a thick and resistant cell wall. Energy- or solvent-consuming steps are therefore needed to overcome this physical barrier and efficiently extract the desired compounds. Moreover, in a biorefinery context, the wall itself represents a valuable co-product. Although accurate knowledge of microalgal cell walls would be useful for product and process development and overall cost reduction, walls are still poorly understood. High discrepancies in structure and/or composition are regularly described within families, genera or species due to phenotypic plasticity, life cycle stage or erroneous taxonomical classification. Massive progress has been made in this latter research area, which gives, when compiled with the studies focusing on cell walls, a better understanding of micro-algal cell walls. This review focuses on the detailed cell wall structure and composition of Chlorophyta with a particular focus on, but not limited to, industrial micro-algae.

Coronary computed tomography angiography for heart team decision-making in multivessel coronary artery disease.

Abstract: Aims Coronary computed tomography angiography (CTA) has emerged as a non-invasive diagnostic method for patients with suspected coronary artery disease, but its usefulness in patients with complex coronary artery disease remains to be investigated. The present study sought to determine the agreement between separate heart teams on treatment decision-making based on either coronary CTA or conventional angiography. Methods and results Separate heart teams composed of an interventional cardiologist, a cardiac surgeon, and a radiologist were randomized to assess the coronary artery disease with either coronary CTA or conventional angiography in patients with de novo left main or three-vessel coronary artery disease. Each heart team, blinded for the other imaging modality, quantified the anatomical complexity using the SYNTAX score and integrated clinical information using the SYNTAX Score II to provide a treatment recommendations based on mortality prediction at 4 years: coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or equipoise between CABG and PCI. The primary endpoint was the agreement between heart teams on the revascularization strategy. The secondary endpoint was the impact of fractional flow reserve derived from coronary CTA (FFRCT) on treatment decision and procedural planning. Overall, 223 patients were included. A treatment recommendation of CABG was made in 28% of the cases with coronary CTA and in 26% with conventional angiography. The agreement concerning treatment decision between coronary CTA and conventional angiography was high (Cohen's kappa 0.82, 95% confidence interval 0.74-0.91). The heart teams agreed on the coronary segments to be revascularized in 80% of the cases. FFRCT was available for 869/1108 lesions (196/223 patients). Fractional flow reserve derived from coronary CTA changed the treatment decision in 7% of the patients. Conclusion In patients with left main or three-vessel coronary artery disease, a heart team treatment decision-making based on coronary CTA showed high agreement with the decision derived from conventional coronary angiography suggesting the potential feasibility of a treatment decision-making and planning based solely on this non-invasive imaging modality and clinical information. Trial registration number NCT02813473.

Bridging the gap: automated steady scaffoldings for 3D printing

Abstract: Fused Filament Fabrication (FFF) is the process of 3D printing objects from melted plastic filament. The hot plastic exits a nozzle and fuses with the part just below, adding a layer of material to the object being formed. However, filament can only be deposited on top of an existing surface. Therefore, overhangs require a disposable support structure to be printed, temporarily supporting the threads of plastic that would otherwise hang in empty space. Existing techniques for support generation fall into two categories: The first allow for very reliable prints by enclosing the bottom of the object in a dense structure, at the expense of increased material usage and build times. The second generate thin hierarchical structures connecting to the surface in a sparse number of points. This uses less material, at the expense of reliability: the part might become unstable, the structure itself may become difficult to print, the bottom surface quality degrades. The user therefore has to correct the structure and its parameters for each new object. We propose to exploit the ability of FFF printers to print bridges across gaps. Since bridges are always supported by pillars at their extremities, they are both stronger and more stable than hierarchical tree structures. Our technique first selects the points to support based on overhang and part stability during the entire print process. It then optimizes for a printable scaffolding composed of bridges and vertical pillars, supporting all points. The result is an automated support generation technique using little material while ensuring fine surface quality and stability during the printing process.