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Institution

University of Lorraine

EducationNancy, France
About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.


Papers
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Journal ArticleDOI
TL;DR: The use of ordered mesoporous carbon and templated macroporous carbon as novel materials to design nanostructured electrodes devoted to sensing and biosensing was discussed in this article.
Abstract: The past few years have seen an explosion in the use of ordered mesoporous carbon and, to lesser extent, templated macroporous carbon, as novel materials to design nanostructured electrodes devoted to sensing and biosensing. These materials offer attractive features that can be exploited in electrochemistry [e.g., good electronic conductivity, great porosity (high specific surface area, large pore volume and size) and widely open ordered structure]. After a brief presentation of these materials (template synthesis, characterization, properties and uses) and the ways to attach them to electrode surfaces (including their basic electrochemical behavior), we review their interest for electroanalytical purposes. We pay particular attention to applications in the fields of preconcentration electroanalysis, electrocatalysis, potentiometry and electrochemical biosensing, and to discussing the advantages of such templated porous carbons over other related nanostructured carbon materials.

130 citations

Journal ArticleDOI
TL;DR: The ABCR score is a simple and clinically relevant index, summing four prognostic variables endorsed in HCC that identifies patients with dismal prognosis who may not benefit from further TACE sessions.

129 citations

Journal ArticleDOI
TL;DR: The distinct impacts of the aminoglycosides examined suggest that their chemical composition and distinct modes of interaction with the ribosome influence PTC read-through efficiency and implicate pleiotropic mechanisms of action beyond decoding.
Abstract: Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional centers within the bacterial ribosome to impact all four principle stages (initiation, elongation, termination, and recycling) of the translation mechanism. The propensity of aminoglycosides to induce miscoding errors that suppress the termination of protein synthesis supports their potential as therapeutic interventions in human diseases associated with premature termination codons (PTCs). However, the sites of interaction of aminoglycosides with the eukaryotic ribosome and their modes of action in eukaryotic translation remain largely unexplored. Here, we use the combination of X-ray crystallography and single-molecule FRET analysis to reveal the interactions of distinct classes of aminoglycosides with the 80S eukaryotic ribosome. Crystal structures of the 80S ribosome in complex with paromomycin, geneticin (G418), gentamicin, and TC007, solved at 3.3- to 3.7-A resolution, reveal multiple aminoglycoside-binding sites within the large and small subunits, wherein the 6′-hydroxyl substituent in ring I serves as a key determinant of binding to the canonical eukaryotic ribosomal decoding center. Multivalent binding interactions with the human ribosome are also evidenced through their capacity to affect large-scale conformational dynamics within the pretranslocation complex that contribute to multiple aspects of the translation mechanism. The distinct impacts of the aminoglycosides examined suggest that their chemical composition and distinct modes of interaction with the ribosome influence PTC read-through efficiency. These findings provide structural and functional insights into aminoglycoside-induced impacts on the eukaryotic ribosome and implicate pleiotropic mechanisms of action beyond decoding.

129 citations

Journal ArticleDOI
01 Sep 2015-Gut
TL;DR: Correlation between indexes is strong and intraobserver reproducibility and interobserver agreement for all indexes is very good, including ‘erosion/ulceration’ and ‘acute inflammatory cells infiltrate/neutrophils in lamina propria’.
Abstract: Background Assessment of disease activity in UC is important for designing an optimal therapeutic strategy. No single histology score is considered optimum. The aim of this study was to compare intraobserver reproducibility and the interobserver agreement of available histological UC activity indexes. Methods One hundred and two biopsy specimens (collected between 2003 and 2014) were scored blindly by three pathologists by determining Geboes, Riley, Gramlich and Gupta indexes and global visual evaluation (GVE). Intraobserver reproducibility and interobserver agreements for index and items of index were studied by intraclass correlation coefficient for quantitative parameter and by κ values and Krippendorff index for qualitative parameters. Relationship between indexes was studied by computation of Pearson9s and Spearman9s correlation coefficients. Results Geboes, Riley, Gramlich and Gupta indexes and GVE showed good intraobserver reproducibility and a good interobserver agreement. Histological items that showed the best interobserver agreement were ‘erosion/ulceration or surface epithelial integrity’ and ‘acute inflammatory cells infiltrate/neutrophils in lamina propria’. The five scores were strongly correlated. Conclusions Correlation between indexes is strong. Intraobserver reproducibility and interobserver agreement for all indexes is very good. Histological items that showed the best interobserver agreement are ‘erosion/ulceration’ and ‘acute inflammatory cells infiltrate/neutrophils in lamina propria’.

129 citations

Journal ArticleDOI
TL;DR: The theoretical study shows that, for an ideally trigonal Ni(II) complex, the orbital degeneracy leads to a first-order spin-orbit coupling that results in a splitting of the M(s) = ± 1 and M(S) = 0 components of the ground spin state of approximately -600 cm(-1).
Abstract: This paper reports the experimental and theoretical investigations of two trigonal bipyramidal Ni(II) complexes, [Ni(Me6tren)Cl](ClO4) (1) and [Ni(Me6tren)Br](Br) (2). High-field, high-frequency electron paramagnetic resonance spectroscopy performed on a single crystal of 1 shows a giant uniaxial magnetic anisotropy with an experimental Dexpt value (energy difference between the Ms = ± 1 and Ms = 0 components of the ground spin state S = 1) estimated to be between −120 and −180 cm–1. The theoretical study shows that, for an ideally trigonal Ni(II) complex, the orbital degeneracy leads to a first-order spin–orbit coupling that results in a splitting of the Ms = ± 1 and Ms = 0 components of approximately −600 cm–1. Despite the Jahn–Teller distortion that removes the ground term degeneracy and reduces the effects of the first-order spin–orbit interaction, the D value remains very large. A good agreement between theoretical and experimental results (theoretical Dtheor between −100 and −200 cm–1) is obtained.

129 citations


Authors

Showing all 12161 results

NameH-indexPapersCitations
Jonathan I. Epstein138112180975
Peter Tugwell129948125480
David Brown105125746827
Faiez Zannad10383990737
Sabu Thomas102155451366
Francis Martin9873343991
João F. Mano9782236401
Jonathan A. Epstein9429927492
Muhammad Imran94305351728
Laurent Peyrin-Biroulet9090134120
Athanase Benetos8339131718
Michel Marre8244439052
Bruno Rossion8033721902
Lyn March7836762536
Alan J. M. Baker7623426080
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202375
2022477
20213,153
20202,987
20192,799
20182,593