Institution
University of Los Andes
Education•Bogotá, Colombia•
About: University of Los Andes is a education organization based out in Bogotá, Colombia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 17616 authors who have published 25555 publications receiving 413463 citations.
Topics: Population, Large Hadron Collider, Standard Model, Lepton, Higgs boson
Papers published on a yearly basis
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University of Los Andes1, Carlos III Health Institute2, National Autonomous University of Mexico3, University of Buenos Aires4, University of Cartagena5, Orlando Regional Medical Center6, National University of San Marcos7, Central University of Venezuela8, Del Rosario University9, Andrés Bello National University10
TL;DR: Se confirma la importancia del manejo inicial y multimodal del dolor, se hace enfasis en the disminucion of los niveles de sedacion y the utilizacion of sedacion profunda solo en casos especificos.
110 citations
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University of Western Ontario1, Cleveland Clinic2, McMaster University3, Yale University4, University of Copenhagen5, The Chinese University of Hong Kong6, University of Los Andes7, Kingston General Hospital8, Cayetano Heredia University9, Monash University10, University of North Carolina at Chapel Hill11, Medical University of Vienna12, Autonomous University of Bucaramanga13, Royal Adelaide Hospital14, Ohio State University15, University of Manitoba16, University of Texas MD Anderson Cancer Center17, University of Toronto18, Mahatma Gandhi Institute of Medical Sciences19, Royal Melbourne Hospital20, Cliniques Universitaires Saint-Luc21
TL;DR: Among patients undergoing major noncardiac surgery, neither aspirin nor clonidine administered perioperatively reduced the risk of acute kidney injury and neither increased therisk of clinically important hypotension.
Abstract: IMPORTANCE: Acute kidney injury, a common complication of surgery, is associated with poor outcomes and high health care costs. Some studies suggest aspirin or clonidine administered during the perioperative period reduces the risk of acute kidney injury; however, these effects are uncertain and each intervention has the potential for harm. OBJECTIVE: To determine whether aspirin compared with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury. DESIGN, SETTING, AND PARTICIPANTS: A 2 × 2 factorial randomized, blinded, clinical trial of 6905 patients undergoing noncardiac surgery from 88 centers in 22 countries with consecutive patients enrolled between January 2011 and December 2013. INTERVENTIONS: Patients were assigned to take aspirin (200 mg) or placebo 2 to 4 hours before surgery and then aspirin (100 mg) or placebo daily up to 30 days after surgery, and were assigned to take oral clonidine (0.2 mg) or placebo 2 to 4 hours before surgery, and then a transdermal clonidine patch (which provided clonidine at 0.2 mg/d) or placebo patch that remained until 72 hours after surgery. MAIN OUTCOMES AND MEASURES: Acute kidney injury was primarily defined as an increase in serum creatinine concentration from the preoperative concentration by either an increase of 0.3 mg/dL or greater (≥26.5 μmol/L) within 48 hours of surgery or an increase of 50% or greater within 7 days of surgery. RESULTS: Aspirin (n = 3443) vs placebo (n = 3462) did not alter the risk of acute kidney injury (13.4% vs 12.3%, respectively; adjusted relative risk, 1.10; 95% CI, 0.96-1.25). Clonidine (n = 3453) vs placebo (n = 3452) did not alter the risk of acute kidney injury (13.0% vs 12.7%, respectively; adjusted relative risk, 1.03; 95% CI, 0.90-1.18). Aspirin increased the risk of major bleeding. In a post hoc analysis, major bleeding was associated with a greater risk of subsequent acute kidney injury (23.3% when bleeding was present vs 12.3% when bleeding was absent; adjusted hazard ratio, 2.20; 95% CI, 1.72-2.83). Similarly, clonidine increased the risk of clinically important hypotension. In a post hoc analysis, clinically important hypotension was associated with a greater risk of subsequent acute kidney injury (14.3% when hypotension was present vs 11.8% when hypotension was absent; adjusted hazard ratio, 1.34; 95% CI, 1.14-1.58). CONCLUSIONS AND RELEVANCE: Among patients undergoing major noncardiac surgery, neither aspirin nor clonidine administered perioperatively reduced the risk of acute kidney injury. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01082874.
110 citations
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TL;DR: A plausible mechanism that explains the role of water is proposed on the basis of experimental observations and previous mechanistic suggestions for transamidation reactions catalyzed by transition metals such as copper and aluminum and represents a significant improvement over other existing methods.
Abstract: The highly efficient transamidation of several primary, secondary, and tertiary amides with aliphatic and aromatic amines (primary and secondary) is described. The reaction is performed in the presence of a 5 mol % concentration of different hydrated salts of Fe(III), and the results show that the presence of water is crucial. The methodology was also applied to urea and phthalimide to demonstrate its versatility and wide substrate scope. An example of its use is an intramolecular application in the synthesis of 2,3-dihydro-5H-benzo[b]-1,4-thiazepin-4-one, which is the bicyclic core of diltiazem and structurally related drugs (Budriesi, R.; Cosimelli, B.; Ioan, P.; Carosati, E.; Ugenti, M. P.; Spisani, R. Curr. Med. Chem. 2007, 14, 279-287). A plausible mechanism that explains the role of water is proposed on the basis of experimental observations and previous mechanistic suggestions for transamidation reactions catalyzed by transition metals such as copper and aluminum. This methodology represents a significant improvement over other existing methods; it can be performed in air and with wet or technical grade solvents.
110 citations
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15 May 2016
TL;DR: The strategic engagement of citizen scientists from sociodemographically diverse communities across the globe as both assessment as well as change agents provides a promising, potentially low-cost, and scalable strategy for creating more active, healthful, and equitable neighborhoods and communities worldwide.
Abstract: Purpose While technology is a major driver of many of society's comforts, conveniences, and advances, it has been responsible, in a significant way, for engineering regular physical activity and a number of other positive health behaviors out of people's daily lives. A key question concerns how to harness information and communication technologies (ICT) to bring about positive changes in the health promotion field. One such approach involves community-engaged "citizen science," in which local residents leverage the potential of ICT to foster data-driven consensus-building and mobilization efforts that advance physical activity at the individual, social, built environment, and policy levels. Method The history of citizen science in the research arena is briefly described and an evidence-based method that embeds citizen science in a multi-level, multi-sectoral community-based participatory research framework for physical activity promotion is presented. Results Several examples of this citizen science-driven community engagement framework for promoting active lifestyles, called "Our Voice", are discussed, including pilot projects from diverse communities in the U.S. as well as internationally. Conclusions The opportunities and challenges involved in leveraging citizen science activities as part of a broader population approach to promoting regular physical activity are explored. The strategic engagement of citizen scientists from socio-demographically diverse communities across the globe as both assessment as well as change agents provides a promising, potentially low-cost and scalable strategy for creating more active, healthful, and equitable neighborhoods and communities worldwide.
110 citations
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01 Nov 2019-Precision Engineering-journal of The International Societies for Precision Engineering and Nanotechnology
TL;DR: The development of X-ray CT metrology is described, beginning with a historical overview that spans the discovery ofX-rays to the invention of CAT scan and focuses with greater detail on its expansion toward industrial dimensional measurements.
Abstract: X-ray computed tomography (also referred to as X-ray CT, CAT scan, or simply ‘CT’) is a technological advancement with expanding applications, from medical imaging and nondestructive evaluation to, more recently, dimensional metrology. The CT technique is now used to measure a specimen's geometrical dimensions (of both internal and external features). As a result, CT presently contributes to dimensional inspection and geometric analysis for technology companies spanning a variety of industries such as aerospace, automotive, electronics, medical devices, plastic components, metalworking, and additive manufacturing (one of the main drivers presently pushing the use of CT for dimensional measurement). For medical diagnoses or other qualitative analyses that depend mainly on feature recognition dimensional accuracy is not necessary. In contrast, for precision engineering applications accurate dimensional measurement is the essence of X-ray CT metrology. This article describes the development of X-ray CT metrology beginning with a historical overview that spans the discovery of X-rays to the invention of CAT scan and focuses with greater detail on its expansion toward industrial dimensional measurements. Following this overview is a brief review of the current state of the art of the technology—specifically focused on issues of metrology—and of the present standardization efforts in the design of acceptance tests for evaluating the metrological performance of X-ray CT. As of writing, the CT metrology technique is still evolving with several technical issues yet to be resolved, in particular, to find better ways of expressing uncertainties associated with CT dimensional measurements. Supported by data indicating a growing commercial/industrial market, this technology appears to be in an ‘early adoption’ phase.
109 citations
Authors
Showing all 17748 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alexander Belyaev | 142 | 1895 | 100796 |
Sarah Catherine Eno | 141 | 1645 | 105935 |
Mitchell Wayne | 139 | 1810 | 108776 |
Kaushik De | 139 | 1625 | 102058 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Randy Ruchti | 137 | 1832 | 107846 |
Gabor Istvan Veres | 135 | 1349 | 96104 |
Raymond Brock | 135 | 1468 | 97859 |
Harrison Prosper | 134 | 1587 | 100607 |
J. Ellison | 133 | 1392 | 92416 |
Gyorgy Vesztergombi | 133 | 1444 | 94821 |
Andrew Brandt | 132 | 1246 | 94676 |
Scott Snyder | 131 | 1317 | 93376 |
Shuai Liu | 129 | 1095 | 80823 |
C. A. Carrillo Montoya | 128 | 1033 | 78628 |