Institution
University of Los Andes
Education•Bogotá, Colombia•
About: University of Los Andes is a education organization based out in Bogotá, Colombia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 17616 authors who have published 25555 publications receiving 413463 citations.
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28 Jan 2014TL;DR: It is important to thoroughly understand the pathophysiologic interconnections underlying PCOS, in order to provide superior therapeutic strategies and warrant improved quality of life to women with this syndrome.
Abstract: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine-metabolic disorder that implies various severe consequences to female health, including alarming rates of infertility. Although its exact etiology remains elusive, it is known to feature several hormonal disturbances, including hyperandrogenemia, insulin resistance (IR), and hyperinsulinemia. Insulin appears to disrupt all components of the hypothalamus-hypophysis-ovary axis, and ovarian tissue insulin resistance results in impaired metabolic signaling but intact mitogenic and steroidogenic activity, favoring hyperandrogenemia, which appears to be the main culprit of the clinical picture in PCOS. In turn, androgens may lead back to IR by increasing levels of free fatty acids and modifying muscle tissue composition and functionality, perpetuating this IR-hyperinsulinemia-hyperandrogenemia cycle. Nonobese women with PCOS showcase several differential features, with unique biochemical and hormonal profiles. Nevertheless, lean and obese patients have chronic inflammation mediating the long term cardiometabolic complications and comorbidities observed in women with PCOS, including dyslipidemia, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. Given these severe implications, it is important to thoroughly understand the pathophysiologic interconnections underlying PCOS, in order to provide superior therapeutic strategies and warrant improved quality of life to women with this syndrome.
281 citations
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University of Edinburgh1, University of Leeds2, University of Exeter3, University College London4, Imperial College London5, National Institute of Amazonian Research6, Naturalis7, Utrecht University8, Australian National University9, Universidad Autónoma Gabriel René Moreno10, National Institute for Space Research11, University of Amsterdam12, Institut national de la recherche agronomique13, Woods Hole Research Center14, Universidade Federal do Acre15, Central University of Ecuador16, Paul Sabatier University17, National Park Service18, National Agrarian University19, University of Texas at Austin20, University of São Paulo21, Smithsonian Institution22, Ferrum College23, World Wide Fund for Nature24, James Cook University25, Universidade do Estado de Mato Grosso26, Indian Institute of Technology Roorkee27, National University of Saint Anthony the Abbot in Cuzco28, Wageningen University and Research Centre29, Duke University30, University of East Anglia31, National University of Colombia32, University of Los Andes33, University of Florida34, Museu Paraense Emílio Goeldi35, Conservation International36, Georgetown University37, University of Wisconsin–Milwaukee38, Smithsonian Tropical Research Institute39, State University of Campinas40, Northern Arizona University41, University of Oxford42
TL;DR: Pantropical biomass maps are widely used by governments and by projects aiming to reduce deforestation using carbon offsets, but may have significant regional biases and carbon accounting techniques must be revised to account for the known ecological variation in tree wood density and allometry.
Abstract: Aim The accurate mapping of forest carbon stocks is essential for understanding the global carbon cycle, for assessing emissions from deforestation, and for rational land-use planning. Remote sensing (RS) is currently the key tool for this purpose, but RS does not estimate vegetation biomass directly, and thus may miss significant spatial variations in forest structure. We test the stated accuracy of pantropical carbon maps using a large independent field dataset. Location Tropical forests of the Amazon basin. The permanent archive of the field plot data can be accessed at: http://dx.doi.org/10.5521/FORESTPLOTS.NET/
276 citations
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TL;DR: In this article, results of searches for heavy stable charged particles produced in pp collisions at 7 and 8 TeV are presented corresponding to an integrated luminosity of 5.0 and 18.8 inverse femtobarns, respectively.
Abstract: Results of searches for heavy stable charged particles produced in pp collisions at sqrt(s) = 7 and 8 TeV are presented corresponding to an integrated luminosity of 5.0 inverse femtobarns and 18.8 inverse femtobarns, respectively. Data collected with the CMS detector are used to study the momentum, energy deposition, and time-of-flight of signal candidates. Leptons with an electric charge between e/3 and 8e, as well as bound states that can undergo charge exchange with the detector material, are studied. Analysis results are presented for various combinations of signatures in the inner tracker only, inner tracker and muon detector, and muon detector only. Detector signatures utilized are long time-of-flight to the outer muon system and anomalously high (or low) energy deposition in the inner tracker. The data are consistent with the expected background, and upper limits are set on the production cross section of long-lived gluinos, scalar top quarks, and scalar tau leptons, as well as pair produced long-lived leptons. Corresponding lower mass limits, ranging up to 1322 GeV for gluinos, are the most stringent to date.
276 citations
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TL;DR: While the functional significance of placental exosomes in pregnancy remains to be fully elucidated, available data support a role in normal placental development and maternal immunotolerance and the application of specific and well-characterized isolation methodologies is requisite to resolving the precise role of exosome in complications of pregnancies and their ultimate clinical utility.
274 citations
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University of South Australia1, University of Adelaide2, Victoria University, Australia3, Palacký University, Olomouc4, Pennington Biomedical Research Center5, Children's Hospital of Eastern Ontario6, University of Cape Town7, University of Porto8, University of Los Andes9, University of Bath10, Syracuse University11, University of Massachusetts Amherst12
TL;DR: The compositional data analysis presented overcomes the lack of adjustment that has plagued traditional statistical methods in the field, and provides robust and reliable insights into the health effects of daily activity behaviours.
Abstract: The health effects of daily activity behaviours (physical activity, sedentary time and sleep) are widely studied. While previous research has largely examined activity behaviours in isolation, recent studies have adjusted for multiple behaviours. However, the inclusion of all activity behaviours in traditional multivariate analyses has not been possible due to the perfect multicollinearity of 24-h time budget data. The ensuing lack of adjustment for known effects on the outcome undermines the validity of study findings. We describe a statistical approach that enables the inclusion of all daily activity behaviours, based on the principles of compositional data analysis. Using data from the International Study of Childhood Obesity, Lifestyle and the Environment, we demonstrate the application of compositional multiple linear regression to estimate adiposity from children's daily activity behaviours expressed as isometric log-ratio coordinates. We present a novel method for predicting change in a continuous outcome based on relative changes within a composition, and for calculating associated confidence intervals to allow for statistical inference. The compositional data analysis presented overcomes the lack of adjustment that has plagued traditional statistical methods in the field, and provides robust and reliable insights into the health effects of daily activity behaviours.
273 citations
Authors
Showing all 17748 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alexander Belyaev | 142 | 1895 | 100796 |
Sarah Catherine Eno | 141 | 1645 | 105935 |
Mitchell Wayne | 139 | 1810 | 108776 |
Kaushik De | 139 | 1625 | 102058 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Randy Ruchti | 137 | 1832 | 107846 |
Gabor Istvan Veres | 135 | 1349 | 96104 |
Raymond Brock | 135 | 1468 | 97859 |
Harrison Prosper | 134 | 1587 | 100607 |
J. Ellison | 133 | 1392 | 92416 |
Gyorgy Vesztergombi | 133 | 1444 | 94821 |
Andrew Brandt | 132 | 1246 | 94676 |
Scott Snyder | 131 | 1317 | 93376 |
Shuai Liu | 129 | 1095 | 80823 |
C. A. Carrillo Montoya | 128 | 1033 | 78628 |