University of Louisville

About: University of Louisville is a education organization based out in Louisville, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 24600 authors who have published 49248 publications receiving 1573346 citations. The organization is also known as: UofL.

Chondroitinase ABC Digestion of the Perineuronal Net Promotes Functional Collateral Sprouting in the Cuneate Nucleus after Cervical Spinal Cord Injury

Abstract: Upregulation of extracellular chondroitin sulfate proteoglycans (CSPGs) after CNS injuries contributes to the impediment of functional recovery by restricting both axonal regeneration and synaptic plasticity In the present study, the effect of degrading CSPGs with the application of the bacterial enzyme chondroitinase ABC (chABC) into the cuneate nucleus of rats partially denervated of forepaw dorsal column axons was examined A dorsal column transection between the C6-C7 dorsal root entry zones was followed immediately by an ipsilateral brainstem injection of either chABC or a bacterial-derived control enzyme [penicillinase (P-ase)] and then subsequently (1 week later) followed with a second brainstem enzyme injection and cholera toxin B subunit (CTB) tracer injection into the ipsilateral forepaw digits and pads After 1 additional week, the rats underwent electrophysiological receptive field mapping of the cuneate nucleus and/or anatomical evaluation Examination of the brainstems of rats from each group revealed that CSPGs had been reduced after chABC treatment Importantly, in the chABC-treated rats (but not in the P-ase controls), a significantly greater area of the cuneate nucleus was occupied by physiologically active CTB traced forepaw afferents that had been spared by the initial cord lesion These results demonstrate, for the first time, a functional change directly linked to anatomical evidence of sprouting by spinal cord afferents after chABC treatment

Integrative Literature Review: Four Emerging Perspectives of Employee Engagement: An Integrative Literature Review:

Abstract: The concept of employee engagement has garnered attention in both practitioner and academic communities and several approaches for understanding engagement have developed. Whereas many authors have...

Exosomes: A Novel Pathway of Local and Distant Intercellular Communication that Facilitates the Growth and Metastasis of Neoplastic Lesions

Abstract: Normal and diseased cells release bilayered membrane-bound nanovesicles into interstitial spaces and into bodily fluids. A subgroup of such microvesicles is called exosomes and is described in blood as 30 to 100 nm in diameter and as spherical to cup-shaped nanoparticles with specific surface molecular characteristics (eg, expression of the tetraspanins CD9, CD81, and CD63). Extracellular microvesicles provide local signals (eg, autocrine and paracrine) and distant endocrine signals to cells via the transfer of their contents, which include signal proteins, lipids, miRNAs, and functional mRNAs. Exosomes and related microvesicles also aid cells in exporting less-needed molecules and potentially harmful molecules, including drugs; in the case of neoplasia, the export of chemotherapeutic drugs may facilitate cellular chemoresistance. Cancers have adapted the exosome and related microvesicles as a pathway by which neoplastic cells communicate with each other (autocrine) and with nonneoplastic cells (paracrine and endocrine); via this pathway, cancer suppresses the immune system and establishes a fertile local and distant environment to support neoplastic growth, invasion, and metastases. Because exosomes mirror and bind to the cells from which they arise, they can be used for delivery of drugs, vaccines, and gene therapy, as biomarkers and targets. We review how exosomes and related extracellular microvesicles facilitate the progression and metastases of cancers and describe how these microvesicles may affect clinical care.

Issues in integrating cellular networks WLANs, AND MANETs: a futuristic heterogeneous wireless network

Abstract: The popularity of wireless communication systems can be seen almost everywhere in the form of cellular networks, WLANs, and WPANs. In addition, small portable devices have been increasingly equipped with multiple communication interfaces building a heterogeneous environment in terms of access technologies. The desired ubiquitous computing environment of the future has to exploit this multitude of connectivity alternatives resulting from diverse wireless communication systems and different access technologies to provide useful services with guaranteed quality to users. Many new applications require a ubiquitous computing environment capable of accessing information from different portable devices at any time and everywhere. This has motivated researchers to integrate various wireless platforms such as cellular networks, WLANs, and MANETs. Integration of different technologies with different capabilities and functionalities is an extremely complex task and involves issues at all layers of the protocol stack. This article envisions an architecture for state-of-the-art heterogeneous multihop networks, and identifies research issues that need to be addressed for successful integration of heterogeneous technologies for the next generation of wireless and mobile networks.