University of Louisville

About: University of Louisville is a education organization based out in Louisville, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 24600 authors who have published 49248 publications receiving 1573346 citations. The organization is also known as: UofL.

Cardio-Oncology: An Update on Cardiotoxicity of Cancer-Related Treatment.

Abstract: Through the success of basic and disease-specific research, cancer survivors are one of the largest growing subsets of individuals accessing the healthcare system. Interestingly, cardiovascular disease is the second leading cause of morbidity and mortality in cancer survivors after recurrent malignancy. This recognition has helped stimulate a collaboration between oncology and cardiology practitioners and researchers, and the portmanteau cardio-oncology (also known as onco-cardiology) can now be found in many medical centers. This collaboration promises new insights into how cancer therapies impact cardiovascular homeostasis and long-term effects on cancer survivors. In this review, we will discuss the most recent views on the cardiotoxicity related to various classes of chemotherapy agents and radiation. We will also discuss broadly the current strategies for treating and preventing cardiovascular effects of cancer therapy.

Perceptions of sex offender registration: collateral consequences and community experiences

Abstract: In the mid-1990s, the Jacob Wetterling Act and Megan's Law were passed, respectively, formalizing the practice of registering sex offenders in publicly accessible, state-wide databases. The laws were passed in an effort to prevent recidivism of sex offenders and to promote community awareness of convicted sex offenders living in communities. However, the creation of these registries have led to numerous unforeseen collateral consequences for offenders. In qualitative in-depth interviews with registered sex offenders in Jefferson County, Kentucky, respondents reported experiencing difficulties with employment and relationships, instances of harassment, stigmatization, and persistent feelings of vulnerability, all of which they believed were attributable to their status as registered sex offenders. The collateral consequences reported by sex offenders are consistent with those reported for felons in past research. However, the extent to which sex offenders experienced these consequences appears to ...

I segment lengths and thin filament periods in skeletal muscle fibers of the Rhesus monkey and the human.

Abstract: The I segment length has been measured and the number of thin filament periods per I segment has been counted in electron micrographs of Rhesus monkey and human leg muscle fibers. The number of I segment periods in the monkey fiber (60) and in the human fiber (66) multiplied by axial periodicity (385 A) in thin filaments of living fibers (Huxley and BROWN, '67) plus 1,000 A allowed for Z line width in living fibers, provided a formula for calculation of I segment lengths in living fibers. The calculated I segment lengths are 2.41 μ for the monkey and 2.64 μ for the human fiber. The ratio of calculated I segment length over an assumed constant thick filament length (1.6 μ) among vertebrates is in close agreement with the ratio of measured I segment length over measured thick filament length in micrographs of frog, rat, monkey and human leg muscle fibers. The calculated I segment length in the frog (1.95 μ) is compared with that of the human (2.64 μ) to show the relation of I segment length to the length-developed tension diagram and to the series elastic components of the skeletal muscle fiber.