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Institution

University of Louisville

EducationLouisville, Kentucky, United States
About: University of Louisville is a education organization based out in Louisville, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 24600 authors who have published 49248 publications receiving 1573346 citations. The organization is also known as: UofL.


Papers
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Journal ArticleDOI
TL;DR: The authors used interviews with a diverse sample of 40 employed mothers to explore how they navigate the "intensive mother" and "ideal worker" ideologies and construct their own accounts of good mothering.
Abstract: Social scientists have provided rich descriptions of the ascendant cultural ideologies surrounding motherhood and paid work. In this article, I use in-depth interviews with a diverse sample of 40 employed mothers to explore how they navigate the “intensive mother” and “ideal worker” ideologies and construct their own accounts of good mothering. Married mothers in this sample construct scripts of “extensive mothering,” in which they delegate substantial amounts of the day-to-day child care to others, and reframe good mothering as being “in charge” of and ultimately responsible for their children’s well-being. Single mothers describe extensive mothering in different ways, and their narratives suggest less accountability to the “intensive mothering” model. Mothers in this sample also justify employment in novel ways: They emphasize the benefits of employment for themselves—not only their children—and they reject the long work hours imposed by an ideal worker model. The article ends with the implications of e...

263 citations

Journal ArticleDOI
TL;DR: The review concludes that the breadth and depth of this book makes it a required staple for every Web mining researcher, student, or practitioner.
Abstract: This paper presents a review of the book "Web Data Mining - Exploring Hyperlinks, Contents, and Usage Data" by Bing Liu. The review concludes that the breadth and depth of this book makes it a required staple for every Web mining researcher, student, or practitioner.

263 citations

Journal ArticleDOI
TL;DR: A soft robotic sleeve that is implanted around the heart and actively compresses and twists to act as a cardiac ventricular assist device, which does not contact blood, obviating the need for anticoagulation therapy or blood thinners, and reduces complications with current Ventricular assist devices, such as clotting and infection.
Abstract: There is much interest in form-fitting, low-modulus, implantable devices or soft robots that can mimic or assist in complex biological functions such as the contraction of heart muscle. We present a soft robotic sleeve that is implanted around the heart and actively compresses and twists to act as a cardiac ventricular assist device. The sleeve does not contact blood, obviating the need for anticoagulation therapy or blood thinners, and reduces complications with current ventricular assist devices, such as clotting and infection. Our approach used a biologically inspired design to orient individual contracting elements or actuators in a layered helical and circumferential fashion, mimicking the orientation of the outer two muscle layers of the mammalian heart. The resulting implantable soft robot mimicked the form and function of the native heart, with a stiffness value of the same order of magnitude as that of the heart tissue. We demonstrated feasibility of this soft sleeve device for supporting heart function in a porcine model of acute heart failure. The soft robotic sleeve can be customized to patient-specific needs and may have the potential to act as a bridge to transplant for patients with heart failure.

263 citations

Journal ArticleDOI
01 May 2004-Diabetes
TL;DR: Data show that both type 1 and type 2 diabetes induce damage at the level of individual myocytes, and that this damage occurs through mechanisms utilizing ROS.
Abstract: Many diabetic patients suffer from a cardiomyopathy that cannot be explained by poor coronary perfusion. Reactive oxygen species (ROS) have been proposed to contribute to this cardiomyopathy. Consistent with this we found evidence for induction of the antioxidant genes for catalase in diabetic OVE26 hearts. To determine whether increased antioxidant protection could reduce diabetic cardiomyopathy, we assessed cardiac morphology and contractility, Ca 2+ handling, malondialdehyde (MDA)-modified proteins, and ROS levels in individual cardiomyocytes isolated from control hearts, OVE26 diabetic hearts, and diabetic hearts overexpressing the antioxidant protein catalase. Diabetic hearts showed damaged mitochondria and myofibrils, reduced myocyte contractility, slowed intracellular Ca 2+ decay, and increased MDA-modified proteins compared with control myocytes. Overexpressing catalase preserved normal cardiac morphology, prevented the contractile defects, and reduced MDA protein modification but did not reverse the slowed Ca 2+ decay induced by diabetes. Additionally, high glucose promoted significantly increased generation of ROS in diabetic cardiomyocytes. Chronic overexpression of catalase or acute in vitro treatment with rotenone, an inhibitor of mitochondrial complex I, or thenoyltrifluoroacetone, an inhibitor of mitochondrial complex II, eliminated excess ROS production in diabetic cardiomyocytes. The structural damage to diabetic mitochondria and the efficacy of mitochondrial inhibitors in reducing ROS suggest that mitochondria are a source of oxidative damage in diabetic cardiomyocytes. We also found that catalase overexpression protected cardiomyocyte contractility in the agouti model of type 2 diabetes. These data show that both type 1 and type 2 diabetes induce damage at the level of individual myocytes, and that this damage occurs through mechanisms utilizing ROS.

263 citations

Journal ArticleDOI
01 Aug 2012-JAMA
TL;DR: Compared with guideline-based usual care, exercise training resulted in a modest reduction in depressive symptoms, although the clinical significance of this improvement is unknown.
Abstract: Context Depression is common in patients with cardiac disease, especially in patients with heart failure, and is associated with increased risk of adverse health outcomes. Some evidence suggests that aerobic exercise may reduce depressive symptoms, but to our knowledge the effects of exercise on depression in patients with heart failure have not been evaluated. Objective To determine whether exercise training will result in greater improvements in depressive symptoms compared with usual care among patients with heart failure. Design, Setting, and Participants Multicenter, randomized controlled trial involving 2322 stable patients treated for heart failure at 82 medical clinical centers in the United States, Canada, and France. Patients who had a left ventricular ejection fraction of 35% or lower, had New York Heart Association class I to IV heart failure, and had completed the Beck Depression Inventory II (BDI-II) score were randomized (1:1) between April 2003 and February 2007. Depressive scores ranged from 0 to 59; scores of 14 or higher are considered clinically significant. Interventions Participants were randomized either to supervised aerobic exercise (goal of 90 min/wk for months 1-3 followed by home exercise with a goal of ≥120 min/wk for months 4-12) or to education and usual guideline-based heart failure care. Main Outcome Measures Composite of death or hospitalization due to any cause and scores on the BDI-II at months 3 and 12. Results Over a median follow-up period of 30 months, 789 patients (68%) died or were hospitalized in the usual care group compared with 759 (66%) in the aerobic exercise group (hazard ratio [HR], 0.89; 95% CI, 0.81 to 0.99; P = .03). The median BDI-II score at study entry was 8, with 28% of the sample having BDI-II scores of 14 or higher. Compared with usual care, aerobic exercise resulted in lower mean BDI-II scores at 3 months (aerobic exercise, 8.95; 95% CI, 8.61 to 9.29 vs usual care, 9.70; 95% CI, 9.34 to 10.06; difference, −0.76; 95% CI,−1.22 to −0.29; P = .002) and at 12 months (aerobic exercise, 8.86; 95% CI, 8.67 to 9.24 vs usual care, 9.54; 95% CI, 9.15 to 9.92; difference, −0.68; 95% CI, −1.20 to −0.16; P = .01). Conclusions Compared with guideline-based usual care, exercise training resulted in a modest reduction in depressive symptoms, although the clinical significance of this improvement is unknown. Trial Registration clinicaltrials.gov Identifier: NCT00047437

262 citations


Authors

Showing all 24802 results

NameH-indexPapersCitations
Robert M. Califf1961561167961
Aaron R. Folsom1811118134044
Yang Gao1682047146301
Stephen J. O'Brien153106293025
James J. Collins15166989476
Anthony E. Lang149102895630
Sw. Banerjee1461906124364
Hermann Kolanoski145127996152
Ferenc A. Jolesz14363166198
Daniel S. Berman141136386136
Aaron T. Beck139536170816
Kevin J. Tracey13856182791
C. Dallapiccola1361717101947
Michael I. Posner134414104201
Alan Sher13248668128
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202373
2022249
20212,489
20202,234
20192,193
20182,153